Evidence map›Paper›PMID 35184045›Full record

ArticleMolecular pharmacology2022

Serotonin-Mediated Activation of Serotonin Receptor Type 1 Oppositely Modulates Voltage-Gated Calcium Channel Currents in Rat Sensory Neurons Innervating Hindlimb Muscle.

Laura Anselmi, Joyce S Kim, Marc P Kaufman, Shouhao Zhou, Victor Ruiz-Velasco

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecular pharmacology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.3field-weighted citation impact, top 50% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 3 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Laura AnselmiDepartment of Anesthesiology and Perioperative Medicine (L.A., V.R.-V.) and Heart and Vascular Institute (J.S.K., M.P.K.), Penn State College of Medicine, Hershey, Pennsylvania; and Department of Public Health Sciences Division of Biostatistics and Bioinformatics, Penn State Cancer Institute, Next-Generation Therapies, Hershey, Pennsylvania (S.Z.).
Joyce S KimDepartment of Anesthesiology and Perioperative Medicine (L.A., V.R.-V.) and Heart and Vascular Institute (J.S.K., M.P.K.), Penn State College of Medicine, Hershey, Pennsylvania; and Department of Public Health Sciences Division of Biostatistics and Bioinformatics, Penn State Cancer Institute, Next-Generation Therapies, Hershey, Pennsylvania (S.Z.).
Marc P KaufmanDepartment of Anesthesiology and Perioperative Medicine (L.A., V.R.-V.) and Heart and Vascular Institute (J.S.K., M.P.K.), Penn State College of Medicine, Hershey, Pennsylvania; and Department of Public Health Sciences Division of Biostatistics and Bioinformatics, Penn State Cancer Institute, Next-Generation Therapies, Hershey, Pennsylvania (S.Z.).
Shouhao ZhouDepartment of Anesthesiology and Perioperative Medicine (L.A., V.R.-V.) and Heart and Vascular Institute (J.S.K., M.P.K.), Penn State College of Medicine, Hershey, Pennsylvania; and Department of Public Health Sciences Division of Biostatistics and Bioinformatics, Penn State Cancer Institute, Next-Generation Therapies, Hershey, Pennsylvania (S.Z.).
Victor Ruiz-VelascoDepartment of Anesthesiology and Perioperative Medicine (L.A., V.R.-V.) and Heart and Vascular Institute (J.S.K., M.P.K.), Penn State College of Medicine, Hershey, Pennsylvania; and Department of Public Health Sciences Division of Biostatistics and Bioinformatics, Penn State Cancer Institute, Next-Generation Therapies, Hershey, Pennsylvania (S.Z.) vruizvelasco@psu.edu.
Penn State Milton S. Hershey Medical Center · USPennsylvania State University · US

Funding

Project 3: Role Played by ASIC, P2X and EP4 Receptors in the Exercise Pressor Reflex in Health and Simulated PADP01HL134609 · NHLBI · PENNSYLVANIA STATE UNIV HERSHEY MED CTR · PI KAUFMAN, MARC PETER · 2017 to 2021
$9.4M
NHLBI NIH HHS P01 HL134609
6 · The paper itself

Abstract

Serotonin (5-HT) is a multifaceted neurotransmitter that has been described to play a role as a peripheral inflammatory mediator when released in ischemic or injured muscle. Dorsal root ganglia (DRG) neurons are key sensors of noxious stimuli that are released under inflammatory conditions or mechanical stress. Little information is available on the specific 5-HT receptor subtypes expressed in primary afferents that help regulate reflex pressor responses. In the present study, the whole-cell patch-clamp technique was employed to examine the modulation of voltage-gated calcium channel (Ca

Indexed as

Receptor, Serotonin, 5-HT1ASerotoninAnimalsCalcium ChannelsHindlimbMusclesRatsReceptors, SerotoninSensory Receptor CellsCalcium ChannelsReceptor, Serotonin, 5-HT1AReceptors, SerotoninSerotonin

Identifiers

PMID35184045
PMCPMC9092463
OpenAlexW4212809325

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.