Evidence map›Paper›PMID 35183789›Full record

ArticleBrain stimulation

Induction of Bdnf from promoter I following electroconvulsive seizures contributes to structural plasticity in neurons of the piriform cortex.

Anthony D Ramnauth, Kristen R Maynard, Alisha S Kardian, BaDoi N Phan, Madhavi Tippani, Sumita Rajpurohit, John W Hobbs, Stephanie Cerceo Page, Andrew E Jaffe, Keri Martinowich

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Brain stimulation. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.0field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 9 citations in OpenAlex.

  1. Psilocybin improves novel object recognition in a rat model of Fragile X Syndrome through the modulation of the BDNF/TrkB signaling pathway.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026
    Article
  2. Article
  3. Review
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  5. Review
  6. Diverse Functions of MultipleBiomolecules · 2023
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

Anthony D RamnauthLieber Institute for Brain Development, Johns Hopkins Medical Campus, Baltimore, MD, USA; Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Kristen R MaynardLieber Institute for Brain Development, Johns Hopkins Medical Campus, Baltimore, MD, USA; Department of Psychiatry & Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD, USA. Electronic address: kristen.maynard@libd.org.
Alisha S KardianLieber Institute for Brain Development, Johns Hopkins Medical Campus, Baltimore, MD, USA.
BaDoi N PhanLieber Institute for Brain Development, Johns Hopkins Medical Campus, Baltimore, MD, USA; Computational Biology Department, School of Computer Science, Carnegie Mellon University, Pittsburgh, PA, USA; Medical Scientist Training Program, School of Medicine, University of Pittsburgh, Pittsburgh, PA, USA.
Madhavi TippaniLieber Institute for Brain Development, Johns Hopkins Medical Campus, Baltimore, MD, USA.
Sumita RajpurohitLieber Institute for Brain Development, Johns Hopkins Medical Campus, Baltimore, MD, USA.
John W HobbsLieber Institute for Brain Development, Johns Hopkins Medical Campus, Baltimore, MD, USA.
Stephanie Cerceo PageLieber Institute for Brain Development, Johns Hopkins Medical Campus, Baltimore, MD, USA.
Andrew E JaffeLieber Institute for Brain Development, Johns Hopkins Medical Campus, Baltimore, MD, USA; Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD, USA; Department of Mental Health, Johns Hopkins University, Baltimore, MD, USA; Department of Biostatistics, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA; Department of Psychiatry & Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Keri MartinowichLieber Institute for Brain Development, Johns Hopkins Medical Campus, Baltimore, MD, USA; Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD, USA; Department of Psychiatry & Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Johns Hopkins University · US

Funding

Regulation of neural activity in fear circuits by promoter IV derived BDNFR01MH105592 · NIMH · LIEBER INSTITUTE, INC. · PI MARTINOWICH, KERI · 2015 to 2024
$5.6M
Epigenomic contribution to the antidepressant responseR21MH118725 · NIMH · LIEBER INSTITUTE, INC. · PI MARTINOWICH, KERI · 2018 to 2019
$513k
NIMH NIH HHS R01 MH105592NIMH NIH HHS R21 MH118725
6 · The paper itself

Abstract

backgroundElectroconvulsive therapy (ECT) efficacy is hypothesized to depend on induction of molecular and cellular events that trigger neuronal plasticity. Investigating how electroconvulsive seizures (ECS) impact plasticity in animal models can help inform our understanding of basic mechanisms by which ECT relieves symptoms of depression. ECS-induced plasticity is associated with differential expression of unique isoforms encoding the neurotrophin, brain-derived neurotrophic factor (BDNF). HYPOTHESIS: We hypothesized that cells expressing the Bdnf exon 1-containing isoform are important for ECS-induced structural plasticity in the piriform cortex, a highly epileptogenic region that is responsive to ECS.

methodsWe selectively labeled Bdnf exon 1-expressing neurons in mouse piriform cortex using Cre recombinase dependent on GFP technology (CRE-DOG). We then quantified changes in dendrite morphology and density of Bdnf exon 1-expressing neurons.

resultsLoss of promoter I-derived BDNF caused changes in spine density and morphology in Bdnf exon 1-expressing neurons following ECS.

conclusionsPromoter I-derived Bdnf is required for ECS-induced dendritic structural plasticity in Bdnf exon 1-expressing neurons.

Indexed as

Brain-Derived Neurotrophic FactorElectroconvulsive TherapyNeuronal PlasticityPiriform CortexAnimalsMiceNeuronsPromoter Regions, GeneticSeizuresBdnf protein, mouseBrain-Derived Neurotrophic FactorBDNFElectroconvulsive seizuresElectroconvulsive therapyPlasticity

Identifiers

PMID35183789
PMCPMC8957536
OpenAlexW4220913340

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.