Evidence map›Paper›PMID 35183655›Full record

ArticlePeptides2022

Angiotensinogen uptake and stimulation of oxidative stress in human pigment retinal epithelial cells.

Victor M Pulgar, Nildris Cruz-Diaz, Brian M Westwood, Mark C Chappell

Open access · greenAbstract read
In one paragraph

Article in Peptides, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.1field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. Internalization of Angiotensin-(1-12) in Adult Retinal Pigment Epithelial-19 Cells.Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics · 2023
    Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Victor M PulgarDepartment of Pharmaceutical Sciences, Campbell University, Buies-Creek, NC, United States; Hypertension & Vascular Research Center, Wake Forest University School of Medicine, Winston-Salem, NC,United States.
Nildris Cruz-DiazHypertension & Vascular Research Center, Wake Forest University School of Medicine, Winston-Salem, NC,United States.
Brian M WestwoodHypertension & Vascular Research Center, Wake Forest University School of Medicine, Winston-Salem, NC,United States.
Mark C ChappellHypertension & Vascular Research Center, Wake Forest University School of Medicine, Winston-Salem, NC,United States. Electronic address: mchappel@wakehealth.edu.
Wake Forest University · USCampbell University · US

Funding

Uric Acid, Klotho and Salt Sensitivity in Young Adults Born PretermR01HL146818 · NHLBI · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI CHAPPELL, MARK C, SHALTOUT, HOSSAM · 2019 to 2023
$4.0M
Postdoctoral Research, Instruction, and Mentoring Experience (PRIME)K12GM102773 · NIGMS · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI HOWLETT, ALLYN C · 2013 to 2018
$2.6M
Novel Angiotensin-(1-7) Endopeptidase in Fetal ProgrammingR21HD084227 · NICHD · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI CHAPPELL, MARK C, ROSE, JAMES C. · 2016 to 2017
$426k
NHLBI NIH HHS R01 HL146818NICHD NIH HHS R21 HD084227NIGMS NIH HHS K12 GM102773
6 · The paper itself

Abstract

We previously reported that isolated proximal tubules (PT) internalize the precursor protein angiotensinogen and that the

Indexed as

AngiotensinogenIodineAngiotensin IIEpithelial CellsHumansOxidative StressReceptor, Angiotensin, Type 1Retinal PigmentsAngiotensin IIAngiotensinogenIodineReceptor, Angiotensin, Type 1Retinal PigmentsAng IIAngiotensinogenARPE-19 cellsGKT131184NADPH oxidaseNOX4Oxidative stress

Identifiers

PMID35183655
PMCPMC11718714
OpenAlexW4213201627

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.