ArticleBiophysical journal2022
Active chemo-mechanical feedbacks dictate the collective migration of cells on patterned surfaces.
Article in Biophysical journal, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
9 citing papers in PubMed, 25 citations in OpenAlex.
- F-actin dynamics regulates collective cell migration by modulating cell shape and stress correlation.Biophysical journal · 2025Article
- Cytoskeletal mechanics in collective cell migration.Biophysical journal · 2025Article
- Mechanochemical dynamics of collective cells and hierarchical topological defects in multicellular lumens.Science advances · 2024Article
- Advances in Regulating Cellular Behavior Using Micropatterns.The Yale journal of biology and medicine · 2023Review
- Cellular mechanisms of wound closure under cyclic stretching.Biophysical journal · 2023Article
- Cyclic stretch-regulated wound healing.Biophysical journal · 2023Article
- Size-dependent response of cells in epithelial tissue modulated by contractile stress fibers.Biophysical journal · 2023Article
- Cell chirality regulates coherent angular motion on small circular substrates.Biophysical journal · 2022Article
- Chemo-mechanical feedback in collective cell migration.Biophysical journal · 2022Article
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Authors and funding
4 authors at 1 institution in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Recent evidence has demonstrated that, when cultured on micro-patterned surfaces, living cells can move in a coordinated manner and form distinct migration patterns, including flowing chain, suspended propagating bridge, rotating vortex, etc. However, the fundamental question of exactly how and why cells migrate in these fashions remains elusive. Here, we present a theoretical investigation to show that the tight interplay between internal cellular activities, such as chemo-mechanical feedbacks and polarization, and external geometrical constraints are behind these intriguing experimental observations. In particular, on narrow strip patterns, strongly force-dependent cellular contractility and intercellular adhesion were found to be critical for reinforcing the leading edge of the migrating cell monolayer and eventually result in the formation of suspended cell bridges flying over nonadhesive regions. On the other hand, a weak force-contractility feedback led to the movement of cells like a flowing chain along the adhesive strip. Finally, we also showed that the random polarity forces generated in migrating cells are responsible for driving them into rotating vortices on strips with width above a threshold value (~10 times the size of the cell).
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.