Evidence map›Paper›PMID 35183520›Full record

ArticleBiophysical journal2022

Desmoglein 2 can undergo Ca

Michael Fuchs, Daniela Kugelmann, Nicolas Schlegel, Franziska Vielmuth, Jens Waschke

Open access · greenAbstract read
In one paragraph

Article in Biophysical journal, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
1.9field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 23 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Review
  6. Review
  7. Article
  8. Article
  9. Article
  10. Article
  11. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Michael FuchsInstitute of Anatomy and Cell Biology, Department I, Faculty of Medicine, Ludwig-Maximilians-Universität Munich, Munich, Germany.
Daniela KugelmannInstitute of Anatomy and Cell Biology, Department I, Faculty of Medicine, Ludwig-Maximilians-Universität Munich, Munich, Germany.
Nicolas SchlegelDepartment of General, Visceral, Vascular and Pediatric Surgery University Hospital Würzburg, Wuerzburg, Germany.
Franziska VielmuthInstitute of Anatomy and Cell Biology, Department I, Faculty of Medicine, Ludwig-Maximilians-Universität Munich, Munich, Germany. Electronic address: Franziska.Vielmuth@med.uni-muenchen.de.
Jens WaschkeInstitute of Anatomy and Cell Biology, Department I, Faculty of Medicine, Ludwig-Maximilians-Universität Munich, Munich, Germany. Electronic address: jens.waschke@med.uni-muenchen.de.
Ludwig-Maximilians-Universität München · DEUniversitätsklinikum Würzburg · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Desmoglein (Dsg) 2 is a ubiquitously expressed desmosomal cadherin. Particularly, it is present in all cell types forming desmosomes, including epithelial cells and cardiac myocytes and is upregulated in the autoimmune skin disease pemphigus. Thus, we here characterized the binding properties of Dsg2 in more detail using atomic force microscopy (AFM). Dsg2 exhibits homophilic interactions and also heterophilic interactions with the desmosomal cadherin desmocollin (Dsc) 2, and further with the classical cadherins E-cadherin (E-Cad) and N-cadherin (N-Cad), which may be relevant for cross talk between desmosomes and adherens junctions in epithelia and cardiac myocytes. We found that all homo- and heterophilic interactions were Ca

Indexed as

Desmoglein 2DesmosomesCadherinsCell AdhesionEpithelial CellsTryptophanCadherinsDesmoglein 2Tryptophan

Identifiers

PMID35183520
PMCPMC9034291
OpenAlexW4213126678

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.