Evidence map›Paper›PMID 35183388›Full record

ArticleVaccine2022

The effect of ChAdOx1 nCov-19 vaccine on arterial thrombosis development and platelet aggregation in female rats.

Bartlomiej Kalaska, Joanna Miklosz, Justyna Swieton, Aleksandra Jakimczuk, Dariusz Pawlak, Andrzej Mogielnicki

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Vaccine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.4field-weighted citation impact, top 40% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 3 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Bartlomiej KalaskaDepartment of Pharmacodynamics, Medical University of Bialystok, Bialystok, Poland. Electronic address: bartlomiej.kalaska@umb.edu.pl.
Joanna MikloszDepartment of Pharmacodynamics, Medical University of Bialystok, Bialystok, Poland.
Justyna SwietonDepartment of Pharmacodynamics, Medical University of Bialystok, Bialystok, Poland.
Aleksandra JakimczukDepartment of Pharmacodynamics, Medical University of Bialystok, Bialystok, Poland.
Dariusz PawlakDepartment of Pharmacodynamics, Medical University of Bialystok, Bialystok, Poland; Department of Pharmacology and Toxicology, Faculty of Medicine, University of Warmia and Mazury in Olsztyn, Olsztyn, Poland.
Andrzej MogielnickiDepartment of Pharmacodynamics, Medical University of Bialystok, Bialystok, Poland.
Medical University of Białystok · PLUniversity of Warmia and Mazury in Olsztyn · PL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

ChAdOx1 nCoV-19 adenoviral vector vaccine (ChAd) against coronavirus disease 2019 has been associated with vaccine-induced thrombosis and thrombocytopenia (VITT), especially in young women who have presented with unusual localized thrombosis after receiving the vaccine. The pathogenesis of VITT remains incompletely understood. We tried to provide new insights into mechanisms underlying this phenomenon in the model of arterial thrombosis electrically induced in the carotid artery of female rats. At 28 days post-vaccination, ChAd induced SARS-CoV-2-specific neutralizing antibody responses in all animals. The analysis of the blood vessel/thrombus area showed slight luminal narrowing of the carotid artery with extravasation of blood in vaccinated rats. These small changes were not accompanied by differences in thrombus weight and composition. The vaccinated animals presented a slight increase (by around 14-24%) in platelet aggregation. ChAd did not significantly affect blood coagulation, platelet counts, and their activation markers. Unaffected thrombus formation, the lack of thrombocytopenia and all the measured blood and hemostasis parameters that predominantly stayed unchanged, indicate that the ChAd does not increase the risk of arterial thrombosis development in female rats.

Indexed as

COVID-19ThrombosisVaccinesAnimalsChAdOx1 nCoV-19COVID-19 VaccinesFemaleHumansPlatelet AggregationRatsSARS-CoV-2ChAdOx1 nCoV-19COVID-19 VaccinesVaccinesAnimalsBlood coagulationBlood plateletsCOVID-19ThrombosisVaccines

Identifiers

PMID35183388
PMCPMC8849837
OpenAlexW4213305067

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.