ArticleBritish journal of anaesthesia2023
The posterior dominant rhythm: an electroencephalographic biomarker for cognitive recovery after general anaesthesia.
Article in British journal of anaesthesia, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01911195 (Reconstructing Consciousness and Cognition), which is not on this map. Cited by 11 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Reconstructing Consciousness and Cognition
Who cites it
11 citing papers in PubMed, 16 citations in OpenAlex.
- Breathe-squeeze: pharmacodynamics of a stimulus-free behavioural paradigm to track conscious states during sedationBritish journal of anaesthesia · 2023Trial
- Predicting delirium in critically Ill COVID-19 patients using EEG-derived data: a machine learning approach.GeroScience · 2026Observational
- Mapping the Digital Mind: A Meta-Analysis of EEG Biomarkers in Cognition, Emotion, and Mental Health.Brain sciences · 2026Review
- Epilepsy Phenotypic Spectrum of NUS1-Related Disorder: A Case Series.Annals of the Child Neurology Society · 2026Article
- EEG criticality as a prognostic tool for functional outcomes in sedated pediatric intensive care patients.Frontiers in computational neuroscience · 2026Article
- Temporal network instability and low-frequency overconnectivity underlie disorders of consciousness in severe brain injury.Scientific reports · 2025Article
- Comparison of power spectra from overnight electroencephalography between patients with Down syndrome and matched control subjects.Journal of sleep research · 2024Article
- [Processed EEG for personalized dosing of anesthetics during general anesthesia].Die Anaesthesiologie · 2023Review
- A Real-Time Neurophysiologic Stress Test for the Aging Brain: Novel Perioperative and ICU Applications of EEG in Older Surgical Patients.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2023Review
- Resting-state prefrontal EEG biomarker in correlation with postoperative delirium in elderly patients.Frontiers in aging neuroscience · 2023Article
- Electroencephalogram Features of Perioperative Neurocognitive Disorders in Elderly Patients: A Narrative Review of the Clinical Literature.Brain sciences · 2022Review
Corrections and comments
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Authors and funding
10 authors at 4 institutions in 2 countries.
Funding
Abstract
backgroundThe posterior dominant rhythm (PDR) was the first oscillatory pattern noted in the EEG. Evoked by wakeful eyelid closure, these oscillations dissipate over seconds during loss of arousal. The peak frequency of the PDR maintains stability over years, suggesting utility as a state biomarker in the surveillance of acute cognitive impairments. This EEG signature has not been systematically investigated for tracking cognitive dysfunction after anaesthetic-induced loss of consciousness.
methodsThis substudy of Reconstructing Consciousness and Cognition (NCT01911195) investigated the PDR and cognitive function in 60 adult volunteers randomised to either 3 h of isoflurane general anaesthesia or resting wakefulness. Serial measurements of EEG power and cognitive task performance were assessed relative to pre-intervention baseline. Mixed-effects models allowed quantification of PDR and neurocognitive trajectories after return of responsiveness (ROR).
resultsIndividuals in the control group showed stability in the PDR peak frequency over several hours (median difference/inter-quartile range [IQR] of 0.02/0.20 Hz, P=0.39). After isoflurane general anaesthesia, the PDR peak frequency was initially reduced at ROR (median difference/IQR of 0.88/0.65 Hz, P<0.001). PDR peak frequency recovered at a rate of 0.20 Hz h
conclusionThe temporal trajectory of the PDR peak frequency could be a useful perioperative marker for tracking cognitive dysfunction on the order of hours after surgery, particularly for cognitive domains of working memory, visuomotor speed, and executive function. CLINICAL
trial registrationNCT01911195.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.