Evidence map›Paper›PMID 35183069›Full record

ArticleThe Journal of chemical physics2022

Intrinsic diffusion resistance of a membrane channel, mean first-passage times between its ends, and equilibrium unidirectional fluxes.

Alexander M Berezhkovskii, Sergey M Bezrukov

Open access · greenAbstract read
In one paragraph

Article in The Journal of chemical physics, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.4field-weighted citation impact, top 47% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Counter-Intuitive Features of Particle Dynamics in Nanopores.International journal of molecular sciences · 2023
    Review
  3. Closed Formula for Transport across Constrictions.Entropy (Basel, Switzerland) · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Alexander M BerezhkovskiiSection on Molecular Transport, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892, USA.ORCID s0000000205640408
Sergey M BezrukovSection on Molecular Transport, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892, USA.ORCID s0000000282098050
National Institutes of Health · US

Funding

Biophysics of Large Membrane ChannelsZIAHD000072 · NICHD · EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT · PI BEZRUKOV, SERGEY M · 2009 to 2025
$22.8M
ANDROGEN METABOLISM IN CHILDHOODR37HD000072 · NICHD · WEILL MEDICAL COLLEGE OF CORNELL UNIV · PI NEW, MARIA I. · 1997 to 2006
$4.3M
Biophysics of Large Membrane ChannelsZ01HD000072 · NICHD · EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT · PI BEZRUKOV, SERGEY M · 2004 to 2008
$1.6M
Intramural NIH HHS Z01 HD000072Intramural NIH HHS ZIA HD000072NICHD NIH HHS R37 HD000072
6 · The paper itself

Abstract

Diffusive flux of solute molecules through a membrane channel driven by the solute concentration difference on the two sides of the membrane is inversely proportional to the channel diffusion resistance. We show that the intrinsic, channel proper, part of this resistance is the ratio of the sum of the mean first-passage times of the molecule between the channel ends and the molecule partition function in the channel. This is derived without appealing to any specific model of the channel and, therefore, is applicable to transport in channels of arbitrary shape and tortuosity and at arbitrary interaction strength of solute molecules with the channel walls.

Identifiers

PMID35183069
PMCPMC8856757
OpenAlexW4213113457

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.