ArticleNeurobiology of aging2022
Lateral entorhinal cortex dysfunction in amnestic mild cognitive impairment.
Article in Neurobiology of aging, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.
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Who cites it
19 citing papers in PubMed, 1 synthesis or guideline pooled it, 29 citations in OpenAlex.
- Convolutional neural network models of structural MRI for discriminating categories of cognitive impairment: a systematic review and meta-analysis.BMC neurology · 2025Pooled it
- Review
- Microstate-Specific Cross-Frequency Coupling Networks: A Spatiotemporal Framework for MCI Identification.CNS neuroscience & therapeutics · 2026Article
- Aging-related vulnerability in dopamine-glutamate neurons weakens entorhinal dopamine signaling and underlies novelty discrimination deficits.Research square · 2026Article
- Pathophysiological roles of neural stem cells in neuropsychiatric diseases: from plasticity to pharmacological targeting.Acta pharmacologica Sinica · 2026Review
- Why 11β-HSD1 inhibitors show variable efficacy in Alzheimer's therapy: an APOE4-dependent HSD11B1 mechanism.Theranostics · 2026Article
- Hippocampal formation-cortical high-fidelity memory networks in healthy older adults during the mnemonic discrimination task.Frontiers in aging neuroscience · 2026Article
- Multimodal non-invasive approaches for early Alzheimer's disease detection: a review of neuroelectrophysiological and neuroimaging techniques.Frontiers in psychiatry · 2026Review
- Evidence for age-related vulnerability in dopamine-glutamate projections to the lateral entorhinal cortex.bioRxiv : the preprint server for biology · 2025Article
- A central role for acetylcholine in entorhinal cortex function and dysfunction with age in humans and mice.Cell reports · 2025Article
- Regression analysis of multiplicative hazards model with time-dependent coefficient for sparse longitudinal covariates.Journal of nonparametric statistics · 2025Article
- Entorhinal cortex-hippocampal circuit connectivity in health and disease.Frontiers in human neuroscience · 2024Review
- Cerebral hyperactivation across the Alzheimer's disease pathological cascade.Brain communications · 2024Review
- Assessing individual variability of the entorhinal subfields in health and disease.The Journal of comparative neurology · 2023Article
- Differential Laminar Activation Dissociates Encoding and Retrieval in the Human Medial and Lateral Entorhinal Cortex.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023Article
- Tau PET burden in Brodmann areas 35 and 36 is associated with individual differences in cognition in non-demented older adults.Frontiers in aging neuroscience · 2023Article
- Entorhinal-Hippocampal Circuit Integrity Is Related to Mnemonic Discrimination and Amyloid-β Pathology in Older Adults.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2022Article
- Assessing mild cognitive impairment using object-location memory in immersive virtual environments.Hippocampus · 2022Article
- The HOPE4MCI study: AGB101 treatment slows progression of entorhinal cortex atrophy inAlzheimer's & dementia (New York, N. Y.)Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
The entorhinal cortex is the site of some of the earliest pathological changes in Alzheimer's disease, including neuronal, synaptic and volumetric loss. Specifically, the lateral entorhinal cortex shows significant accumulation of tau neurofibrillary tangles in the amnestic mild cognitive impairment (aMCI) phase of Alzheimer's disease. Although decreased entorhinal cortex activation has been observed in patients with aMCI in the context of impaired memory function, it remains unclear if functional changes in the entorhinal cortex can be localized to the lateral or medial entorhinal cortex. To assess subregion specific changes in the lateral and medial entorhinal cortex, patients with aMCI and healthy aged-matched control participants underwent high-resolution structural and functional magnetic resonance imaging. Patients with aMCI showed significantly reduced volume, and decreased activation localized to the lateral entorhinal cortex but not the medial entorhinal cortex. These results show that structural and functional changes associated with impaired memory function differentially engage the lateral entorhinal cortex in patients with aMCI, consistent with the locus of early disease related pathology.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.