Evidence map›Paper›PMID 35182817›Full record

ArticleBiological psychiatry. Cognitive neuroscience and neuroimaging2022

A Developmental Perspective on Facets of Impulsivity and Brain Activity Correlates From Adolescence to Adulthood.

Anna Kaiser, Nathalie E Holz, Tobias Banaschewski, Sarah Baumeister, Arun L W Bokde, Sylvane Desrivières, Herta Flor, Juliane H Fröhner, Antoine Grigis, Hugh Garavan and 17 more

Open access · hybridAbstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Biological psychiatry. Cognitive neuroscience and neuroimaging, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
2.1field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 19 citations in OpenAlex.

  1. Premature release of action sequences in adolescent male rats.Frontiers in behavioral neuroscience · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

27 authors at 18 institutions in 6 countries.

Anna KaiserDepartment of Child and Adolescent Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany. Electronic address: anna.kaiser@zi-mannheim.de.
Nathalie E HolzDepartment of Child and Adolescent Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany; Donders Center for Brain, Cognition and Behavior, Radboud University Nijmegen, Nijmegen, the Netherlands; Department for Cognitive Neuroscience, Radboud University Medical Center Nijmegen, Nijmegen, the Netherlands.
Tobias BanaschewskiDepartment of Child and Adolescent Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.
Sarah BaumeisterDepartment of Child and Adolescent Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.
Arun L W BokdeDiscipline of Psychiatry, School of Medicine and Trinity College Institute of Neuroscience, Trinity College Dublin, Dublin, Ireland.
Sylvane DesrivièresCentre for Population Neuroscience and Precision Medicine, Institute of Psychiatry, Psychology & Neuroscience, Social, Genetic and Developmental Psychiatry Centre, King's College London, London, United Kingdom.
Herta FlorInstitute of Cognitive and Clinical Neuroscience, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany; Department of Psychology, School of Social Sciences, University of Mannheim, Mannheim, Germany.
Juliane H FröhnerDepartment of Psychiatry and Neuroimaging Center, Technical University Dresden, Dresden, Germany.
Antoine GrigisNeuroSpin, Commissariat à l'énergie atomique, Université Paris-Saclay, Gif-sur-Yvette, France.
Hugh GaravanDepartment of Psychology, University of Vermont, Burlington, Vermont.
Penny GowlandSir Peter Mansfield Imaging Centre School of Physics and Astronomy, University of Nottingham, Nottingham, United Kingdom.
Andreas HeinzDepartment of Psychiatry and Psychotherapy, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Berlin, Germany.
Bernd IttermannPhysikalisch-Technische Bundesanstalt, Braunschweig and Berlin, Germany.
Jean-Luc MartinotInstitut National de la Santé et de la Recherche Médicale, Institut National de la Santé et de la Recherche Médicale U A10 "Trajectoires développementales en psychiatrie", Université Paris-Saclay, Ecole Normale supérieure Paris-Saclay, Centre National de la Recherche Scientifique, Centre Borelli, Gif-sur-Yvette, France.
Marie-Laure Paillère MartinotInstitut National de la Santé et de la Recherche Médicale, Institut National de la Santé et de la Recherche Médicale U A10 "Trajectoires développementales en psychiatrie", Université Paris-Saclay, Ecole Normale supérieure Paris-Saclay, Centre National de la Recherche Scientifique, Centre Borelli, Gif-sur-Yvette, France; Department of Child and Adolescent Psychiatry, Pitié-Salpêtrière Hospital, L'Assistance Publique-Hôpitaux de Paris Sorbonne Université, Paris, France.
Eric ArtigesInstitut National de la Santé et de la Recherche Médicale, Institut National de la Santé et de la Recherche Médicale U A10 "Trajectoires développementales en psychiatrie", Université Paris-Saclay, Ecole Normale supérieure Paris-Saclay, Centre National de la Recherche Scientifique, Centre Borelli, Gif-sur-Yvette, France; Psychiatry Department 91G16, Orsay Hospital, Orsay, France.
Sabina MillenetDepartment of Child and Adolescent Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.
Dimitri Papadopoulos OrfanosNeuroSpin, Commissariat à l'énergie atomique, Université Paris-Saclay, Gif-sur-Yvette, France.
Luise PoustkaDepartment of Child and Adolescent Psychiatry and Psychotherapy, University Medical Centre Göttingen, Göttingen, Germany.
Emanuel SchwarzDepartment of Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.
Michael N SmolkaDepartment of Psychiatry and Neuroimaging Center, Technical University Dresden, Dresden, Germany.
Henrik WalterDepartment of Psychiatry and Psychotherapy, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Berlin, Germany; Department of Psychiatry, University of Vermont, Burlington, Vermont.
Robert WhelanSchool of Psychology and Global Brain Health Institute, Trinity College Dublin, Dublin, Ireland.
Gunter SchumannPopulation Neuroscience Research Group, Department of Psychiatry and Psychotherapy, Campus Charite Mitte, Humboldt University, Berlin, Germany; Leibniz Institute for Neurobiology, Magdeburg, Germany; Centre for Population Neuroscience and Precision Medicine, Institute of Psychiatry, Psychology & Neuroscience, Social, Genetic and Developmental Psychiatry Centre, King's College London, London, United Kingdom; Institute for Science and Technology of Brain-inspired Intelligence, Fudan University, Shanghai, China.
Daniel BrandeisDepartment of Child and Adolescent Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany; Department of Child and Adolescent Psychiatry and Psychotherapy, University Hospital of Psychiatry, University of Zürich, Zürich, Switzerland; Neuroscience Center Zürich, Swiss Federal Institute of Technology and University of Zürich, Zürich, Switzerland.
Frauke NeesDepartment of Child and Adolescent Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany; Institute of Cognitive and Clinical Neuroscience, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany; Institute of Medical Psychology and Medical Sociology, University Medical Center Schleswig Holstein, Kiel University, Kiel, Germany.
IMAGEN Consortium
University Hospital Heidelberg · DEHeidelberg University · DETrinity College Dublin · IETU Dresden · DEUniversity of Vermont · USCentral Institute of Mental Health · DEKing's College London · GBCentre Giovanni BorelliCommissariat à l'Énergie Atomique et aux Énergies Alternatives · FRFreie Universität Berlin · DELaboratoire de Mesure du Carbone 14 · FRUniversité Paris-Saclay · FRUniversity of Göttingen · DEUniversity of Nottingham · GBHumboldt-Universität zu Berlin · DEInserm · FRLaboratoire de Biologie et Pharmacologie Appliquée · FRPhysikalisch-Technische Bundesanstalt · DE

Funding

Training U54EB020403 · NIBIB · UNIVERSITY OF SOUTHERN CALIFORNIA · PI THOMPSON, PAUL M · 2014 to 2018
$10.1M
A decentralized macro and micro gene-by-environment interaction analysis of substance use behavior and its brain biomarkers R01DA049238 · NIDA · GEORGIA STATE UNIVERSITY · PI CALHOUN, VINCE D, LIU, JINGYU · 2019 to 2023
$2.9M
Axon, Testosterone and Mental Health during AdolescenceR01MH085772 · NIMH · BAYCREST CENTRE FOR GERIATRIC CARE · PI PAUS, TOMAS · 2010 to 2014
$1.5M
ENIGMA World Aging CenterR56AG058854 · NIA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI THOMPSON, PAUL M · 2018 to 2018
$683k
Medical Research Council MR/N000390/1Medical Research Council MR/R00465X/1Medical Research Council MR/S020306/1Medical Research Council MR/W002418/1MRF_ MRF-058-0004-RG-DESRIMRF_ MRF-058-0009-RG-DESR-C0759NIA NIH HHS R56 AG058854NIBIB NIH HHS U54 EB020403NIDA NIH HHS R01 DA049238NIMH NIH HHS R01 MH085772
6 · The paper itself

Abstract

backgroundOn a theoretical level, impulsivity represents a multidimensional construct associated with acting without foresight, inefficient inhibitory response control, and alterations in reward processing. On an empirical level, relationships and changes in associations between different measures of impulsivity from adolescence into young adulthood and their relation to neural activity during inhibitory control and reward anticipation have not been fully understood.

methodsWe used data from IMAGEN, a longitudinal multicenter, population-based cohort study in which 2034 healthy adolescents were investigated at age 14, and 1383 were reassessed as young adults at age 19. We measured the construct of trait impulsivity using self-report questionnaires and neurocognitive indices of decisional impulsivity. With functional magnetic resonance imaging, we assessed brain activity during inhibition error processing using the stop signal task and during reward anticipation in the monetary incentive delay task. Correlations were analyzed, and mixed-effect models were fitted to explore developmental and predictive effects.

resultsAll self-report and neurocognitive measures of impulsivity proved to be correlated during adolescence and young adulthood. Further, pre-supplementary motor area and inferior frontal gyrus activity during inhibition error processing was associated with trait impulsivity in adolescence, whereas in young adulthood, a trend-level association with reward anticipation activity in the ventral striatum was found. For adult delay discounting, a trend-level predictive effect of adolescent neural activity during inhibition error processing emerged.

conclusionsOur findings help to inform theories of impulsivity about the development of its multidimensional nature and associated brain activity patterns and highlight the need for taking functional brain development into account when evaluating neuromarker candidates.

Indexed as

Impulsive BehaviorVentral StriatumAdolescentAdultCohort StudiesHumansMagnetic Resonance ImagingRewardYoung AdultBiomarkerDevelopmental trajectoriesImpulsivityInhibitory controlPredictionReward anticipation

Identifiers

PMID35182817
PMCPMC9636026
OpenAlexW4213256839

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.