ArticleClinical and experimental dental research2022
Partial epithelial-mesenchymal transition during enamel development.
Article in Clinical and experimental dental research, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed, 2 citations in OpenAlex.
- A multi-modal profiling workflow of transcriptomics and biomineralization demonstrated on a tooth-on-chip model.MethodsX · 2026Article
- Partial epithelial-mesenchymal transition during enamel development.Clinical and experimental dental research · 2022Article
- Membrana preformativa: Unveiling the unexplored facets of dental development.Journal of oral biology and craniofacial researchArticle
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesWe set out to investigate whether a hybrid stem-like p-EMT phenotype develops during murine molar enamel development in vivo. SETTING AND SAMPLE POPULATION: Histology specimens incorporating molar tooth buds harvested from mice at post-natal day 4 (P4) were included in our studies. MATERIALS AND
methodsWe employed double immunofluorescence staining to analyze the simultaneous expression of the epithelial marker E-cadherin and the mesenchymal marker N-cadherin in histology specimens with tooth buds harvested from P4 mice. Moreover, we evaluated the expression of the core master stem cell markers Oct4 and Sox2, as well as the mature ameloblast marker amelogenin.
resultsHere we document the co-expression of E-cadherin and N-cadherin in a sub-population of pre-ameloblasts in the inner enamel epithelium suggestive of the presence of a hybrid epithelial/mesenchymal phenotype resulting from p-EMT. Moreover, the core stem cell factors Oct4 and Sox2 colocalized with E-cadherin expressing pre-ameloblasts, whereas the mesenchymal marker N-cadherin was expressed specifically by amelogenin-positive mature secretory ameloblasts.
conclusionsThe differentiation of E-cadherin-positive pre-ameloblasts towards N-cadherin-positive mature secretory ameloblasts transition through a previously unidentified epithelial/mesenchymal stage derived through p-EMT, co-expressing the master transcription factors Oct4 and Sox2.
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Registered trials
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