ArticleFASEB journal : official publication of the Federation of American Societies for Experimental Biology2022
Human intelectin-2 (ITLN2) is selectively expressed by secretory Paneth cells.
Article in FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 22 citations in OpenAlex.
- Intelectin-2 is a broad-spectrum antimicrobial lectin.Nature communications · 2026Article
- The role of omentin-1 in female reproduction: a critical review.The Journal of reproduction and development · 2026Review
- Disentangling the impact of obesity, diet, host factors, and microbiota on small intestinal antimicrobial peptide expression.Gut microbes · 2025Article
- Transcriptional Profiling of Abomasal Mucosa from Young Calves Experimentally Infected withInternational journal of molecular sciences · 2025Article
- Application of a human lectin array to rapid in vitro screening of sugar-based epitopes that can be used as targeting tags for therapeutics.Glycobiology · 2025Article
- Soluble Human Lectins at the Host-Microbe Interface.Annual review of biochemistry · 2024Review
- Potential Involvement of the South American Lungfish Intelectin-2 in Innate-Associated Immune Modulation.International journal of molecular sciences · 2024Article
- Application of enzyme-linked immunosorbent assay to detect antimicrobial peptides in human intestinal lumen.Journal of immunological methods · 2024Article
- FOXO inhibition rescues α-defensin expression in human intestinal organoids.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Intestinal α-Defensins Play a Minor Role in Modulating the Small Intestinal Microbiota Composition as Compared to Diet.Microbiology spectrum · 2023Article
- Intelectin-1 binds and alters the localization of the mucus barrier-modifying bacterium Akkermansia muciniphila.The Journal of experimental medicine · 2023Article
- Multifaceted involvements of Paneth cells in various diseases within intestine and systemically.Frontiers in immunology · 2023Review
- Human intelectin-2 (ITLN2) is selectively expressed by secretory Paneth cells.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2022Article
- Characterization of an intelectin-1 (Frontiers in immunology · 2022Article
- Current and future aspects of IBD research and treatment: The 2022 perspective.Frontiers in gastroenterology (Lausanne, Switzerland) · 2022Review
Corrections and comments
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Authors and funding
7 authors at 4 institutions in 3 countries.
Funding
Abstract
Intelectins (intestinal lectins) are highly conserved across chordate evolution and have been implicated in various human diseases, including Crohn's disease (CD). The human genome encodes two intelectin genes, intelectin-1 (ITLN1) and intelectin-2 (ITLN2). Other than its high sequence similarity with ITLN1, little is known about ITLN2. To address this void in knowledge, we report that ITLN2 exhibits discrete, yet notable differences from ITLN1 in primary structure, including a unique amino terminus, as well as changes in amino acid residues associated with the glycan-binding activity of ITLN1. We identified that ITLN2 is a highly abundant Paneth cell-specific product, which localizes to secretory granules, and is expressed as a multimeric protein in the small intestine. In surgical specimens of ileal CD, ITLN2 mRNA levels were reduced approximately five-fold compared to control specimens. The ileal expression of ITLN2 was unaffected by previously reported disease-associated variants in ITLN2 and CD-associated variants in neighboring ITLN1 as well as NOD2 and ATG16L1. ITLN2 mRNA expression was undetectable in control colon tissue; however, in both ulcerative colitis (UC) and colonic CD, metaplastic Paneth cells were found to express ITLN2. Together, the data reported establish the groundwork for understanding ITLN2 function(s) in the intestine, including its possible role in CD.
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Registered trials
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