Evidence map›Paper›PMID 35182330›Full record

ArticleMolecular and cellular biochemistry2022

Menin regulates lipid deposition in mouse hepatocytes via interacting with transcription factor FoxO1.

Shengxuan Wang, Tingjun Liu, Lili Sun, Hongxia Du, Zhongjin Xu, Ranran Li, Ying Yu, Yongjiang Mao, Kerong Shi

Abstract read
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In one paragraph

Article in Molecular and cellular biochemistry, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.4field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 10 citations in OpenAlex.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Shengxuan WangCollege of Animal Science and Technology, Shandong Key Laboratory of Animal Bioengineering and Disease Prevention, Shandong Agricultural University, No. 61 Daizong Street, Taian, Shandong, 271018, China.
Tingjun LiuCollege of Animal Science and Technology, Shandong Key Laboratory of Animal Bioengineering and Disease Prevention, Shandong Agricultural University, No. 61 Daizong Street, Taian, Shandong, 271018, China.
Lili SunCollege of Animal Science and Technology, Shandong Key Laboratory of Animal Bioengineering and Disease Prevention, Shandong Agricultural University, No. 61 Daizong Street, Taian, Shandong, 271018, China.
Hongxia DuCollege of Animal Science and Technology, Shandong Key Laboratory of Animal Bioengineering and Disease Prevention, Shandong Agricultural University, No. 61 Daizong Street, Taian, Shandong, 271018, China.
Zhongjin XuCollege of Animal Science and Technology, Shandong Key Laboratory of Animal Bioengineering and Disease Prevention, Shandong Agricultural University, No. 61 Daizong Street, Taian, Shandong, 271018, China.
Ranran LiCollege of Animal Science and Technology, Shandong Key Laboratory of Animal Bioengineering and Disease Prevention, Shandong Agricultural University, No. 61 Daizong Street, Taian, Shandong, 271018, China.
Ying YuNational Engineering Laboratory for Animal Breeding, MOA Key Laboratory of Animal Genetics and Breeding, Department of Animal Genetics and Breeding, China Agricultural University, Beijing, 100093, China.
Yongjiang MaoKey Laboratory of Animal Genetics & Breeding and Molecular Design of Jiangsu Province, Yangzhou University, Yangzhou, 225009, China.
Kerong ShiCollege of Animal Science and Technology, Shandong Key Laboratory of Animal Bioengineering and Disease Prevention, Shandong Agricultural University, No. 61 Daizong Street, Taian, Shandong, 271018, China. krshi@sdau.edu.cn.ORCID http://orcid.org/0000-0003-1966-7473
Shandong Agricultural University · CNChina Agricultural University · CNYangzhou University · CN

Funding

key project of agricultural fine breeding of shandong province 2016LZGC030key project of agricultural fine breeding of shandong province 2019LZGC011national natural science foundation of china 31402054natural science foundation of shandong province ZR2013CM013natural science foundation of shandong province ZR2020MC166
6 · The paper itself

Abstract

Non-alcoholic fatty liver disease (NAFLD) is rapidly being recognized as the leading cause of chronic liver disease worldwide. Men1, encoding protein of menin, is a key causative gene of multiple endocrine neoplasia type 1 syndrome including pancreatic tumor. It is known that insulin that secretes by endocrine tissue pancreatic islets plays a critical role in hepatic metabolism. Mouse model of hemizygous deletion of Men1 was shown to have severe hepatic metabolism disorders. However, the molecular function of menin on lipid deposition in hepatocytes needs to be further studied. Transcriptome sequencing does show that expression suppression of Men1 in mouse hepatocytes widely affect signaling pathways involved in hepatic metabolism, such as fatty acid metabolism, insulin response, glucose metabolism and inflammation. Further molecular studies indicates that menin overexpression inhibits expressions of the fat synthesis genes Srebp-1c, Fas, and Acc1, the fat differentiation genes Pparγ1 and Pparγ2, and the fat transport gene Cd36, thereby inhibiting the fat accumulation in hepatocytes. The biological process of menin regulating hepatic lipid metabolism was accomplished by interacting with the transcription factor FoxO1, which is also found to be critical for lipid metabolism. Moreover, menin responds to insulin in hepatocytes and mediates its regulatory effect on hepatic metabolism. Our findings suggest that menin is a crucial mediation factor in regulating the hepatic fat deposition, suggesting it could be a potential important therapeutic target for NAFLD.

Indexed as

Non-alcoholic Fatty Liver DiseaseAnimalsCD36 AntigensForkhead Box Protein O1HepatocytesInsulinLipid MetabolismLipidsLiverMiceMice, Inbred C57BLProto-Oncogene ProteinsSterol Regulatory Element Binding Protein 1CD36 AntigensForkhead Box Protein O1Foxo1 protein, mouseInsulinLipidsMen1 protein, mouseProto-Oncogene ProteinsSterol Regulatory Element Binding Protein 1FoxO1HepatocyteLipid metabolismMeninNon-alcoholic fatty liver disease (NAFLD)

Identifiers

PMID35182330
OpenAlexW4213124903

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.