Evidence map›Paper›PMID 35182283›Full record

ArticleAIDS and behavior2022

PrEP Use, Sexual Behaviour, and PrEP Adherence Among Men who have Sex with Men Living in Wales Prior to and During the COVID-19 Pandemic.

D Gillespie, Z Couzens, M de Bruin, D A Hughes, A Jones, R Ma, A Williams, F Wood, K Blee, H S Bradshaw and 3 more

Open access · hybridAbstract read
In one paragraph

Article in AIDS and behavior, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed, 2 pooled it
1.5field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 2 syntheses or guidelines pooled it, 16 citations in OpenAlex.

  1. Pooled it
  2. Pre-exposure Prophylaxis Adherence Among Men Who Have Sex With Men: A Systematic Review and Meta-analysis.Journal of preventive medicine and public health = Yebang Uihakhoe chi · 2024
    Pooled it
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  4. Review
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  6. HIV Pre-Exposure Prophylaxis (PrEP) Users' Experiences of PrEP Access, Sexual Behaviour, and Well-Being During the COVID-19 Pandemic: A Welsh Qualitative Study.Health expectations : an international journal of public participation in health care and health policy · 2024
    Article
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  11. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 9 institutions in 2 countries.

D GillespieCentre for Trials Research, College of Biomedical & Life Sciences, School of Medicine, Cardiff University, Cardiff, Wales, UK. gillespied1@cardiff.ac.uk.ORCID http://orcid.org/0000-0002-6934-2928
Z CouzensPublic Health Wales NHS Trust, Cardiff, Wales, UK.
M de BruinRadboud University Medical Center, Institute of Health Sciences, IQ Healthcare, Nijmegen, Netherlands.
D A HughesCentre for Health Economics and Medicines Evaluation, Bangor University, Bangor, Wales, UK.
A JonesPolicy, Research and International Development, Public Health Wales, Cardiff, Wales, UK.
R MaImperial College London, London, England, UK.
A WilliamsCentre for Trials Research, College of Biomedical & Life Sciences, School of Medicine, Cardiff University, Cardiff, Wales, UK.
F WoodDivision of Population Medicine and PRIME Centre Wales, College of Biomedical & Life Sciences, School of Medicine, Cardiff University, Cardiff, Wales, UK.
K BleeSexual Health Department, Glan Clwyd Hospital, Betsi Cadwaladr University Health Board, Rhyl, Wales, UK.
H S BradshawSexual Health Department, Singleton Hospital, Swansea Bay University Health Board, Swansea, Wales, UK.
R DraytonSexual Health Department, Cardiff Royal Infirmary, Cardiff and Vale University Health Board, Cardiff, Wales, UK.
C KnapperCordell Centre, Royal Gwent Hospital, Aneurin Bevan University Health Board, Newport, Wales, UK.
K HoodCentre for Trials Research, College of Biomedical & Life Sciences, School of Medicine, Cardiff University, Cardiff, Wales, UK.
Cardiff University · GBPublic Health Wales · GBBangor University · GBCardiff and Vale University Health Board · GBGlan Clwyd Hospital · GBImperial College London · GBRadboud University Nijmegen · NLRoyal Gwent Hospital · GBSwansea Bay University Health Board · GB

Funding

HCRW_ HF-17-1411
6 · The paper itself

Abstract

We examined PrEP use, condomless anal sex (CAS), and PrEP adherence among men who have sex with men (MSM) attending sexual health clinics in Wales, UK. In addition, we explored the association between the introduction of measures to control transmission of SARS-CoV-2 on these outcomes. We conducted an ecological momentary assessment study of individuals in receipt of PrEP in Wales. Participants used an electronic medication cap to record PrEP use and completed weekly sexual behaviour surveys. We defined adherence to daily PrEP as the percentage of CAS episodes covered by daily PrEP (preceded by ≥ 3 days of PrEP and followed by ≥ 2 days). Sixty participants were recruited between September 2019 and January 2020. PrEP use data prior to the introduction of control measures were available over 5785 person-days (88%) and following their introduction 7537 person-days (80%). Data on CAS episodes were available for 5559 (85%) and 7354 (78%) person-days prior to and following control measures respectively. Prior to the introduction of control measures, PrEP was taken on 3791/5785 (66%) days, there were CAS episodes on 506/5559 (9%) days, and 207/406 (51%) of CAS episodes were covered by an adequate amount of daily PrEP. The introduction of pandemic-related control measures was associated with a reduction in PrEP use (OR 0.44, 95%CI 0.20-0.95), CAS (OR 0.35, 95%CI 0.17-0.69), and PrEP adherence (RR = 0.55, 95%CI 0.34-0.89) and this may have implications for the health and wellbeing of PrEP users and, in addition to disruption across sexual health services, may contribute to wider threats across the HIV prevention cascade.

Indexed as

Anti-HIV AgentsCOVID-19HIV InfectionsPre-Exposure ProphylaxisSexual and Gender MinoritiesHomosexuality, MaleHumansMaleMedication AdherencePandemicsSARS-CoV-2Sexual BehaviorWalesAnti-HIV AgentsAdherenceCOVID-19HIV preventionPrEPSexual behaviour

Identifiers

PMID35182283
PMCPMC8857895
OpenAlexW4213302912

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.