Evidence map›Paper›PMID 35182282›Full record

ArticleAIDS and behavior2022

Predictive Validity of a Computerized Battery for Identifying Neurocognitive Impairments Among Children Living with HIV in Botswana.

Amelia E Van Pelt, Tyler M Moore, J Cobb Scott, Onkemetse Phoi, Lingani Mbakile-Mahlanza, Knashawn H Morales, Ruben C Gur, Shathani Rampa, Mogomotsi Matshaba, Elizabeth D Lowenthal

Open access · greenAbstract read
In one paragraph

Article in AIDS and behavior, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 50% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 3 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 7 institutions in 2 countries.

Amelia E Van PeltDepartment of Biostatistics, Epidemiology and Informatics, Perelman School of Medicine at the University of Pennsylvania, 423 Guardian Drive, Blockley Hall Office 107, Philadelphia, PA, USA. vanpel@pennmedicine.upenn.edu.ORCID http://orcid.org/0000-0002-5671-7479
Tyler M MooreDepartment of Psychiatry, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA.
J Cobb ScottDepartment of Psychiatry, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA.
Onkemetse PhoiBotswana-Baylor Children's Clinical Centre of Excellence, Gaborone, Botswana.
Lingani Mbakile-MahlanzaDepartment of Psychology, University of Botswana, Gaborone, Botswana.
Knashawn H MoralesDepartment of Biostatistics, Epidemiology and Informatics, Perelman School of Medicine at the University of Pennsylvania, 423 Guardian Drive, Blockley Hall Office 107, Philadelphia, PA, USA.
Ruben C GurDepartment of Psychiatry, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA.
Shathani RampaDepartment of Psychology, University of Botswana, Gaborone, Botswana.
Mogomotsi MatshabaBotswana-Baylor Children's Clinical Centre of Excellence, Gaborone, Botswana.
Elizabeth D LowenthalDepartment of Biostatistics, Epidemiology and Informatics, Perelman School of Medicine at the University of Pennsylvania, 423 Guardian Drive, Blockley Hall Office 107, Philadelphia, PA, USA.
Children's Hospital of Philadelphia · USLifespan · USUniversity of Botswana · BWBaylor College of Medicine · USBotswana-Baylor Children's Clinical Center of Excellence · BWPhiladelphia VA Medical Center · USUniversity of Pennsylvania · US

Funding

Penn Mental Health AIDS Research CenterP30MH097488 · NIMH · UNIVERSITY OF PENNSYLVANIA · PI Knashawn Hodge Morales · 2013 to 2026
$23.5M
Creating an adaptive screening tool for detecting neurocognitive deficits and psychopathology across the lifespanR01MH117014 · NIMH · UNIVERSITY OF PENNSYLVANIA · PI GUR, RUBEN C. · 2019 to 2022
$2.9M
A Computerized Neurocognitive Battery for Use in Youth Affected by HIV in Resource-limited SettingsR01HD095278 · NICHD · CHILDREN'S HOSP OF PHILADELPHIA · PI LOWENTHAL, ELIZABETH DAWN, SCOTT, JAMES COBB · 2018 to 2021
$1.6M
Preparing for Use of a Computerized Battery to Identify Neurocognitive Impairments among HIV-affected Youth in BotswanaF31HD101346 · NICHD · UNIVERSITY OF PENNSYLVANIA · PI VAN PELT, AMELIA ELIZABETH · 2020 to 2020
$42k
NICHD NIH HHS F31 HD101346NICHD NIH HHS R01 HD095278NIMH NIH HHS P30 MH097488NIMH NIH HHS R01 MH117014
6 · The paper itself

Abstract

Children living with HIV (HIV+) experience increased risk of neurocognitive deficits, but standardized cognitive testing is limited in low-resource, high-prevalence settings. The Penn Computerized Neurocognitive Battery (PennCNB) was adapted for use in Botswana. This study evaluated the criterion validity of a locally adapted version of the PennCNB among a cohort of HIV+ individuals aged 10-17 years in Botswana. Participants completed the PennCNB and a comprehensive professional consensus assessment consisting of pencil-and-paper psychological assessments, clinical interview, and review of academic performance. Seventy-two participants were classified as cases (i.e., with cognitive impairment; N = 48) or controls (i.e., without cognitive impairment; N = 24). Sensitivity, specificity, positive predictive value, negative predictive value, and the area under receiver operating characteristic curves were calculated. Discrimination was acceptable, and prediction improved as the threshold for PennCNB impairment was less conservative. This research contributes to the validation of the PennCNB for use among children affected by HIV in Botswana.

Indexed as

Cognitive DysfunctionHIV InfectionsBotswanaChildCohort StudiesHumansNeuropsychological TestsBotswanaCriterion validityNeurocognitive assessmentSetswana translationYouth

Identifiers

PMID35182282
PMCPMC9256777
OpenAlexW4213009401

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.