Evidence map›Paper›PMID 35182274›Full record

ArticleNeurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology2022

Effects of low-intensity training on the brain and muscle in the congenital muscular dystrophy 1D model.

Clarissa M Comim, Jaime A Soares, Adriano Alberti, Viviane Freiberger, Letícia Ventura, Paula Dias, Aryadnne L Schactae, Leoberto R Grigollo, Amanda V Steckert, Daniel F Martins and 3 more

Erratum issuedAbstract read
PubMed Publisher
In one paragraph

Article in Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.1field-weighted citation impact, top 60% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

13 authors at 2 institutions in 2 countries.

Clarissa M ComimResearch Group in Neurodevelopment of Childhood and Adolescence, Laboratory of Experimental Neuroscience, Postgraduate Program in Health Sciences, University of South Santa Catarina (UNISUL), Avenida Pedra Branca, 25, Pedra Branca Palhoça, SC, 88137-270, Brazil.
Jaime A SoaresResearch Group in Neurodevelopment of Childhood and Adolescence, Laboratory of Experimental Neuroscience, Postgraduate Program in Health Sciences, University of South Santa Catarina (UNISUL), Avenida Pedra Branca, 25, Pedra Branca Palhoça, SC, 88137-270, Brazil.
Adriano AlbertiResearch Group in Neurodevelopment of Childhood and Adolescence, Laboratory of Experimental Neuroscience, Postgraduate Program in Health Sciences, University of South Santa Catarina (UNISUL), Avenida Pedra Branca, 25, Pedra Branca Palhoça, SC, 88137-270, Brazil. adrianoalberti90@hotmail.com.ORCID http://orcid.org/0000-0003-0313-0380
Viviane FreibergerResearch Group in Neurodevelopment of Childhood and Adolescence, Laboratory of Experimental Neuroscience, Postgraduate Program in Health Sciences, University of South Santa Catarina (UNISUL), Avenida Pedra Branca, 25, Pedra Branca Palhoça, SC, 88137-270, Brazil.
Letícia VenturaResearch Group in Neurodevelopment of Childhood and Adolescence, Laboratory of Experimental Neuroscience, Postgraduate Program in Health Sciences, University of South Santa Catarina (UNISUL), Avenida Pedra Branca, 25, Pedra Branca Palhoça, SC, 88137-270, Brazil.
Paula DiasResearch Group in Neurodevelopment of Childhood and Adolescence, Laboratory of Experimental Neuroscience, Postgraduate Program in Health Sciences, University of South Santa Catarina (UNISUL), Avenida Pedra Branca, 25, Pedra Branca Palhoça, SC, 88137-270, Brazil.
Aryadnne L SchactaeResearch Group in Neurodevelopment of Childhood and Adolescence, Laboratory of Experimental Neuroscience, Postgraduate Program in Health Sciences, University of South Santa Catarina (UNISUL), Avenida Pedra Branca, 25, Pedra Branca Palhoça, SC, 88137-270, Brazil.
Leoberto R GrigolloResearch Group in Neurodevelopment of Childhood and Adolescence, Laboratory of Experimental Neuroscience, Postgraduate Program in Health Sciences, University of South Santa Catarina (UNISUL), Avenida Pedra Branca, 25, Pedra Branca Palhoça, SC, 88137-270, Brazil.
Amanda V SteckertTranslational Psychiatry Laboratory, Graduate Program in Health Sciences, University of Southern Santa Catarina (UNESC), Criciúma, SC, Brazil.
Daniel F MartinsResearch Group in Neurodevelopment of Childhood and Adolescence, Laboratory of Experimental Neuroscience, Postgraduate Program in Health Sciences, University of South Santa Catarina (UNISUL), Avenida Pedra Branca, 25, Pedra Branca Palhoça, SC, 88137-270, Brazil.
Rudy J Nodari JuniorResearch Department, Salus Dermatoglifia, Luzerna, 89609-000, Santa Catarina, Brazil.
Mariz VainzofTranslational Psychiatry Laboratory, Graduate Program in Health Sciences, University of Southern Santa Catarina (UNESC), Criciúma, SC, Brazil.
João QuevedoHuman Genome Research Center, Biosciences Institute, University of São Paulo, São Paulo, Brazil.
Universidade do Sul de Santa Catarina · BRThe University of Texas MD Anderson Cancer Center · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionCongenital Muscular Dystrophy type 1D (MDC1D) is characterized by a hypoglycosylation of α-dystroglycan protein (α-DG), and this may be strongly implicated in increased skeletal muscle tissue degeneration and abnormal brain development, leading to cognitive impairment. However, the pathophysiology of brain involvement is still unclear. Low-intensity exercise training (LIET) is known to contribute to decreased muscle degeneration in animal models of other forms of progressive muscular dystrophies.

aimThe objective of this study was to analyze the effects of LIET on cognitive involvement and oxidative stress in brain tissue and gastrocnemius muscle.

methodsMale homozygous (Large

resultsLIET was observed to reverse the alteration in aversive and habituation memory. Increased protein carbonylation in the striatum, prefrontal cortex, and hippocampus and lipid peroxidation in the prefrontal cortex and hippocampus were also reversed by LIET. In the evaluation of the antioxidant activity, LIET increased catalase activity in the hippocampus and cortex. In the gastrocnemius, LIET decreased the protein carbonylation and lipid peroxidation and increased catalase and superoxide dismutase activity.

conclusionIn conclusion, it can be inferred that LIET for 8 weeks was able to reverse the cognitive damage and oxidative stress in brain tissue and gastrocnemius muscle in MDC1D animals.

Indexed as

BrainMuscle, SkeletalMuscular DystrophiesPhysical Conditioning, AnimalAnimalsCatalaseIntellectual DisabilityMaleMiceOxidative StressSuperoxide DismutaseCatalaseSuperoxide DismutaseCentral nervous systemLargemyd miceLow-intensity exercise trainingMemoryOxidative stress

Identifiers

PMID35182274
OpenAlexW4212949366

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.