SynthesisJournal of assisted reproduction and genetics2022
Recurrent pregnancy loss: fewer chromosomal abnormalities in products of conception? a meta-analysis.
Synthesis in Journal of assisted reproduction and genetics, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 25 citations in OpenAlex.
- Miscarriage history is not associated with embryonic aneuploidy in women under 38 years of age with recurrent pregnancy loss.Frontiers in endocrinology · 2026Article
- A Machine Learning Model for Predicting Recurrent Pregnancy Loss: Retrospective Integration of Routine Serum IL-33, C-Reactive Protein, and Lymphocyte Subset Counts.International journal of general medicine · 2026Article
- Hydroxychloroquine in recurrent pregnancy loss: data from a French prospective multicenter registry.Human reproduction (Oxford, England) · 2024Article
- Fetal deaths from birth defects in Hunan Province, China, 2016-2020.Scientific reports · 2024Article
- Two novel TMEM67 variations in a Chinese family with recurrent pregnancy loss: a case report.BMC medical genomics · 2024Article
- Risk factors for maternal near-miss in an undeveloped province in south-central China, 2012-2022.BMC public health · 2024Article
- Multivariate logistic regression analysis of risk factors for birth defects: a study from population-based surveillance data.BMC public health · 2024Article
- Kinesin-7 CENP-E mediates chromosome alignment and spindle assembly checkpoint in meiosis I.Chromosoma · 2024Article
- Patterns of Cytogenomic Findings from a Case Series of Recurrent Pregnancy Loss Provide Insight into the Extent of Genetic Defects Causing Miscarriages.Global medical genetics · 2024Article
- Evaluation of chromosomal abnormalities in the postnatal cohort: A single-center study on 14,242 patients.Journal of clinical laboratory analysis · 2024Article
- Chromosomal Abnormalities in Early Pregnancy Losses: A Study of 900 Samples.Balkan journal of medical genetics : BJMG · 2023Article
- Recognition of the Subtypes Classification and Diagnostic Signature Based on RNA N6-Methyladenosine Regulators in Recurrent Spontaneous Abortion.Reproductive sciences (Thousand Oaks, Calif.) · 2023Article
- Investigating the "Fetal Side" in Recurrent Pregnancy Loss: Reliability of Cell-Free DNA Testing in Detecting Chromosomal Abnormalities of Miscarriage Tissue.Journal of clinical medicine · 2023Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo compare the prevalence of chromosomal abnormalities detected in products of conception (POCs) between recurrent pregnancy loss and sporadic pregnancy loss.
methodsA systematic search was performed in the PubMed and Embase databases from inception to December 31, 2020. Relevant studies analysing the association between the number of pregnancy losses and the incidence of chromosomal abnormalities were included. Independent data extraction was conducted and study quality was assessed. Meta-analyses were carried out to calculate odds ratios by using fixed- or random-effects models according to statistical homogeneity.
resultsA total of 8320 POCs in 19 studies were identified for the meta-analyses. The incidence of chromosomal abnormalities in sporadic pregnancy loss was significantly higher than that in recurrent pregnancy loss. In subgroup analyses, the following studies reported a high incidence of abnormal outcomes of sporadic pregnancy loss: studies with ≥ 300 samples, studies published before 2014, studies conducted in European and American countries, and studies with analyses using conventional karyotype techniques. Moreover, the incidence of chromosomal abnormalities in women with two pregnancy losses was significantly higher than that in women with three or more pregnancy losses. However, there was no difference in the distribution of abnormal types between sporadic and recurrent pregnancy loss or between two and three or more pregnancy losses.
conclusionsThe prevalence of chromosomal abnormalities detected in POCs was lower in recurrent pregnancy loss than in sporadic pregnancy loss, and decreased with an increasing number of pregnancy losses.
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