Evidence map›Paper›PMID 35182261›Full record

ArticleResearch on child and adolescent psychopathology2022

The Impact of Irritability and Callous Unemotional Traits on Reward Positivity in Youth with ADHD and Conduct Problems.

James Waxmonsky, Whitney Fosco, Daniel Waschbusch, Dara Babinski, Raman Baweja, Samantha Pegg, Vanessa Cao, Delshad Shroff, Autumn Kujawa

Abstract read
In one paragraph

Article in Research on child and adolescent psychopathology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

James WaxmonskyDepartment of Psychiatry, Penn State College of Medicine, Hershey, PA, USA. jwaxmonsky@pennstatehealth.psu.edu.ORCID 0000-0002-5563-3417
Whitney FoscoDepartment of Psychiatry, Penn State College of Medicine, Hershey, PA, USA.
Daniel WaschbuschDepartment of Psychiatry, Penn State College of Medicine, Hershey, PA, USA.
Dara BabinskiDepartment of Psychiatry, Penn State College of Medicine, Hershey, PA, USA.
Raman BawejaDepartment of Psychiatry, Penn State College of Medicine, Hershey, PA, USA.
Samantha PeggDepartment of Psychology and Human Development, Vanderbilt University, Nashville, TN, USA.
Vanessa CaoDepartment of Psychiatry, Penn State College of Medicine, Hershey, PA, USA.
Delshad ShroffDepartment of Psychiatry, Penn State College of Medicine, Hershey, PA, USA.
Autumn KujawaDepartment of Psychology and Human Development, Vanderbilt University, Nashville, TN, USA.

Funding

Overall: Eunice Kennedy Shriver Intellectual and Developmental Disabilities Research Center at VanderbiltP50HD103537 · NICHD · VANDERBILT UNIVERSITY MEDICAL CENTER · PI Lea K Davis · 2020 to 2026
$10.3M
LIFE-SPAN DEVELOPMENT OF NORMAL AND ABNORMAL BEHAVIORT32MH018921 · NIMH · VANDERBILT UNIVERSITY · PI HUMPHREYS, KATHRYN LEIGH · 1989 to 2024
$6.7M
NICHD NIH HHS P50 HD103537NIMH NIH HHS T32 MH018921
6 · The paper itself

Abstract

Children with attention-deficit/hyperactivity disorder (ADHD) and conduct problems exhibit significant variability in functioning and treatment response that cannot be fully accounted for by differences in symptom severity. Reward responsivity (RR) is a potential transdiagnostic means to account for this variability. Irritability and callous-unemotional (CU) traits moderate associations between both ADHD and conduct problems with multiple realms of functioning. Both are theorized to be associated with RR, but associations in clinical samples are unknown. In 48 youth ages 5-12 with ADHD referred for treatment of conduct problems, we examined RR using a guessing task where participants select a door icon to win and lose money. Analyses focused on the reward positivity (RewP) event-related potential in response to gain and loss feedback, which reliably peaks approximately 300 ms after feedback. Frequentist and Bayesian approaches assessed main effects of ADHD, Conduct Disorder (CD) and non-irritable Oppositional Defiant Disorder (ODD) symptoms with RR, plus interactions between symptoms and affective dimensions (irritability, CU). CD and ODD were hypothesized to be associated with altered RR, with irritability and CU moderating these associations. Across models, a reliable CD x irritability interaction emerged, indicating enhanced RewP when irritability was elevated and CD symptoms were low. CU did not moderate any associations with RR, and little support was found for associations between RR and other symptom domains. As neural response to reward varied with levels of irritability and CD symptoms, RR may hold potential as a clinically-relevant biomarker in youth with ADHD and conduct problems.

Indexed as

Attention Deficit Disorder with HyperactivityConduct DisorderAdolescentBayes TheoremChildChild, PreschoolHumansRewardAttention-deficitCallous Unemotional TraitsConduct ProblemsEvent-Related PotentialsHyperactivity DisorderIrritabilityReward

Identifiers

PMID35182261
PMCPMC9388699

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.