ArticleEuropean journal of applied physiology2022
Transcriptomic modulation in response to high-intensity interval training in monocytes of older women with type 2 diabetes.
Article in European journal of applied physiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 1 of them a synthesis that pooled it.
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Who cites it
3 citing papers in PubMed, 1 synthesis or guideline pooled it, 4 citations in OpenAlex.
- Effects of high intensity interval training (HIIT) on cardiopulmonary fitness and physical function in middle-aged and elderly women: a systematic review and meta-analysis.Frontiers in physiology · 2026Pooled it
- The role of exercise physiology in the United Nations' sustainable development goals.European journal of applied physiology · 2023Article
- Enhanced SHP-1 Expression in Podocyturia Is Associated with Kidney Dysfunction in Patients with Diabetes.Kidney360 · 2022Article
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Authors and funding
8 authors at 3 institutions in 1 country.
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Abstract
purposeType 2 diabetes is associated with a higher risk of cardiovascular diseases, lowering the quality of life and increasing mortality rates of affected individuals. Circulating monocytes are tightly involved in the atherosclerosis process leading to cardiovascular diseases (CVD), and their inflammatory profile can be modified by exercise. The objective was to exploratory identify genes associated with CVD that could be regulated by high-intensity interval training (HIIT) in monocytes of type 2 diabetes patients.
methodsNext-generation RNA sequencing (RNA-seq) analyses were conducted on isolated circulating monocytes (CD14
resultsFollowing the intervention, a reduction of resting diastolic blood pressure was observed. Concomitant with this result, 56 genes were found to be downregulated following HIIT intervention in isolated monocytes. A large proportion of the regulated genes was involved in cellular adhesion, migration and differentiation into an "atherosclerosis-specific" macrophage phenotype.
conclusionThe downregulation of transcripts in monocytes globally suggests a favorable cardiovascular effect of the HIIT in older women with type 2 diabetes. In the context of precision medicine and personalized exercise prescription, shedding light on the fundamental mechanisms underlying HIIT effects on the gene profile of immune cells is essential to develop efficient nonpharmacological strategies to prevent CVD in high-risk population.
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