Evidence map›Paper›PMID 35182158›Full record

Observational studyDiabetologia2022

Urinary albumin/creatinine ratio tertiles predict risk of diabetic retinopathy progression: a natural history study from the Adolescent Cardio-Renal Intervention Trial (AdDIT) observational cohort.

Paul Z Benitez-Aguirre, M Loredana Marcovecchio, Scott T Chiesa, Maria E Craig, Tien Y Wong, Elizabeth A Davis, Andrew Cotterill, Jenny J Couper, Fergus J Cameron, Farid H Mahmud and 9 more

Open access · hybridAbstract readObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in Diabetologia, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 1 pooled it
2.1field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 1 synthesis or guideline pooled it, 15 citations in OpenAlex.

  1. Pooled it
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  8. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors at 13 institutions in 4 countries.

Paul Z Benitez-AguirreInstitute of Endocrinology and Diabetes, The Children's Hospital at Westmead, Sydney, Australia.ORCID 0000-0002-7687-2898
M Loredana MarcovecchioDepartment of Paediatrics, University of Cambridge, Cambridge, UK. mlm45@medschl.cam.ac.uk.
Scott T ChiesaInstitute of Cardiovascular Science, University College London, London, UK.
Maria E CraigInstitute of Endocrinology and Diabetes, The Children's Hospital at Westmead, Sydney, Australia.
Tien Y WongCentre for Eye Research Australia, Melbourne, VIC, Australia.
Elizabeth A DavisDepartment of Endocrinology and Diabetes, Princess Margaret Hospital for Children, Perth, WA, Australia.
Andrew CotterillUniversity of Queensland, Brisbane, QLD, Australia.
Jenny J CouperEndocrinology and Diabetes Centre, Women's and Children's Hospital, and Robinson Institute, University of Adelaide, Adelaide, SA, Australia.
Fergus J CameronDepartment of Endocrinology and Diabetes, Royal Children's Hospital, Melbourne, VIC, Australia.
Farid H MahmudDivision of Endocrinology, Hospital for Sick Children, Toronto, ON, Canada.
H Andrew W NeilOxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Oxford, UK.
Timothy W JonesDepartment of Endocrinology and Diabetes, Princess Margaret Hospital for Children, Perth, WA, Australia.
Lauren A B HodgsonCentre for Eye Research Australia, Melbourne, VIC, Australia.
R Neil DaltonSt Thomas' Hospital, Well Child Laboratory, Evelina London Children's Hospital, London, UK.
Sally M MarshallTranslational and Clinical Research Institute, Newcastle University, Newcastle, UK.
John DeanfieldInstitute of Cardiovascular Science, University College London, London, UK.
David B DungerDepartment of Paediatrics, University of Cambridge, Cambridge, UK.
Kim C DonaghueInstitute of Endocrinology and Diabetes, The Children's Hospital at Westmead, Sydney, Australia. kim.donaghue@health.nsw.gov.au.
Adolescent Type 1 Diabetes Cardio-Renal Intervention Trial (AdDIT)
The University of Sydney · AUThe Kids Research Institute Australia · AUUniversity College London · GBUniversity of Cambridge · GBCentre for Eye Research Australia · AUHospital for Sick Children · CANational University of Singapore · SGNewcastle University · GBRoyal Children's Hospital · AUSt Thomas' Hospital · GBThe University of Queensland · AUUniversity of Oxford · GBWomen's and Children's Hospital · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

aims/hypothesisWe hypothesised that adolescents with type 1 diabetes with a urinary albumin/creatinine ratio (ACR) in the upper tertile of the normal range (high ACR) are at greater risk of three-step diabetic retinopathy progression (3DR) independent of glycaemic control.

methodsThis was a prospective observational study in 710 normoalbuminuric adolescents with type 1 diabetes from the non-intervention cohorts of the Adolescent Cardio-Renal Intervention Trial (AdDIT). Participants were classified as 'high ACR' or 'low ACR' (lowest and middle ACR tertiles) using baseline standardised log

resultsAt baseline mean ± SD age was 14.3 ± 1.6 years and mean ± SD diabetes duration was 7.2 ± 3.3 years. After a median of 3.2 years, 83/710 (12%) had developed 3DR. In multivariable analysis, high ACR (HR 2.1 [1.3, 3.3], p=0.001), higher mean IFCC HbA CONCLUSIONS/

interpretationHigh ACR is associated with greater risk of 3DR in adolescents, providing a target for future intervention studies.

trial registrationisrctn.org ISRCTN91419926.

Indexed as

Diabetes Mellitus, Type 1Diabetic NephropathiesDiabetic RetinopathyAdolescentAlbuminsAlbuminuriaChildCreatinineHumansRisk FactorsAlbuminsCreatinineAdDITAdolescentsDiabetic nephropathyDiabetic retinopathy progressionKidney functionMicrovascular complicationsType 1 diabetes

Identifiers

PMID35182158
PMCPMC8960571
OpenAlexW4213085757

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.