Evidence map›Paper›PMID 35182051›Full record

ArticleFEBS open bio2022

MAP kinases differentially bind and phosphorylate NOS3 via two unique NOS3 sites.

Xzaviar K V Solone, Amber L Caldara, Brady Wells, Hao Qiao, Lydia R Wade, John C Salerno, Katy A Helms, Katherine E R Smith, Jonathan L McMurry, Carol A Chrestensen

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in FEBS open bio, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 56% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

Xzaviar K V SoloneDepartment of Molecular & Cellular Biology, Kennesaw State University, GA, USA.
Amber L CaldaraDepartment of Molecular & Cellular Biology, Kennesaw State University, GA, USA.
Brady WellsDepartment of Chemistry & Biochemistry, Kennesaw State University, GA, USA.
Hao QiaoDepartment of Chemistry & Biochemistry, Kennesaw State University, GA, USA.
Lydia R WadeDepartment of Chemistry & Biochemistry, Kennesaw State University, GA, USA.
John C SalernoDepartment of Molecular & Cellular Biology, Kennesaw State University, GA, USA.
Katy A HelmsDepartment of Molecular & Cellular Biology, Kennesaw State University, GA, USA.
Katherine E R SmithDepartment of Chemistry & Biochemistry, Kennesaw State University, GA, USA.
Jonathan L McMurryDepartment of Molecular & Cellular Biology, Kennesaw State University, GA, USA.
Carol A ChrestensenDepartment of Chemistry & Biochemistry, Kennesaw State University, GA, USA.ORCID 0000-0002-8027-2836
Kennesaw State University · US

Funding

Peach State Bridges to the DoctorateR25GM111565 · NIGMS · KENNESAW STATE UNIVERSITY · PI BRANDS, MICHAEL W., GIBSON, GREGORY C · 2015 to 2019
$1.0M
Cell-Penetrating Peptide-Adaptors for Intracellular Cargo DeliveryR15EB028609 · NIBIB · KENNESAW STATE UNIVERSITY · PI MCMURRY, JONATHAN L · 2019 to 2023
$802k
Dissecting the role of MAP kinases and RSK in the regulation of eNOSR15GM110634 · NIGMS · KENNESAW STATE UNIVERSITY · PI CHRESTENSEN, CAROL ANN · 2016 to 2016
$395k
NIBIB NIH HHS EB028609NIBIB NIH HHS R15 EB028609NIGMS NIH HHS GM110634-01A1NIGMS NIH HHS GM111565NIGMS NIH HHS R15 GM110634NIGMS NIH HHS R25 GM111565
6 · The paper itself

Abstract

Nitric oxide synthase 3 (NOS3) is a major vasoprotective enzyme that catalyzes the conversion of l-arginine to nitric oxide (NO) in response to a significant number of signaling pathways. Here, we provide evidence that NOS3 interactions with MAP kinases have physiological relevance. Binding interactions of NOS3 with c-Jun N-terminal kinase (JNK1

Indexed as

Endothelial CellsMitogen-Activated Protein KinasesBinding SitesHumansNitric Oxide Synthase Type IIIPeptidesPhosphorylationMitogen-Activated Protein KinasesNitric Oxide Synthase Type IIINOS3 protein, humanPeptidesERK2JNK1α1NOS3optical biosensingp38αsignaling

Identifiers

PMID35182051
PMCPMC9063426
OpenAlexW4213365194

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.