Observational studyESC heart failure2022
Prevalence and prognostic impact of cognitive frailty in elderly patients with heart failure: sub-analysis of FRAGILE-HF.
Observational study in ESC heart failure, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 4 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
23 citing papers in PubMed, 4 syntheses or guidelines pooled it, 55 citations in OpenAlex.
- Prevalence and associated factors of cognitive frailty in older adults with heart failure: a systematic review and meta-analysis.Frontiers in public health · 2026Pooled it
- Prevalence and influencing factors of cognitive frailty in patients with chronic heart failure: a meta-analysis.Frontiers in cardiovascular medicine · 2026Pooled it
- Models for identifying cognitive frailty in hospitalized older adults with chronic heart failure in China: a systematic review.Frontiers in public health · 2026Pooled it
- Handgrip strength and the prognosis of patients with heart failure: A meta-analysis.Clinical cardiology · 2023Pooled it
- Association of physical activity and life space with cognitive frailty in patients on hemodialysis: the REPnet-HD study.International urology and nephrology · 2026Article
- Prevalence and predictive factors of cognitive impairment among hospitalized older adults in iran: a cross-sectional study, 2024.Aging clinical and experimental research · 2026Article
- Wearable Device-Measured Physical Activity for Predicting Hospitalization-Associated Disability in Older Patients With Heart Failure.Circulation reports · 2026Article
- Frailty determinants in heart failure: Inflammatory markers, cognitive impairment and psychosocial interaction.ESC heart failure · 2025Article
- Investigating frailty and quality of life in patients with heart failure and CKD (FRAIL study).ESC heart failure · 2025Article
- Observational
- Risk factors and a nomogram for predicting cognitive frailty in Chinese patients with lung cancer receiving drug therapy: A single-center cross-sectional study.Thoracic cancer · 2024Article
- Role of Cognitive Frailty in Older Adults With Cardiovascular Disease.Journal of the American Heart Association · 2024Review
- Prevalence and modifiable risk factors of cognitive frailty in patients with chronic heart failure in China: a cross-sectional study.BMC cardiovascular disorders · 2024Article
- Article
- Mapping cognitive function screening instruments for patients with heart failure: A scoping review.Belitung nursing journal · 2024Article
- Feasibility, acceptability, and outcome responsiveness of the SYMPERHEART intervention to support symptom perception in persons with heart failure and their informal caregivers: a feasibility quasi-experimental study.Pilot and feasibility studies · 2023Article
- Frailty and heart failure: State-of-the-art review.Journal of cachexia, sarcopenia and muscle · 2023Review
- Development and validation of a nomogram-assisted tool to predict potentially reversible cognitive frailty in Chinese community-living older adults.Aging clinical and experimental research · 2023Article
- Latent Subtype of Cognitive Frailty among Multimorbidity Older Adults and Their Association with Social Relationships.Healthcare (Basel, Switzerland) · 2023Article
- The concurrent impact of mild cognitive impairment and frailty syndrome in heart failure.Archives of medical science : AMS · 2023Article
Corrections and comments
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Authors and funding
23 authors at 18 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimsAlthough evidence suggests that cognitive decline and physical frailty in elderly patients with heart failure (HF) are associated with prognosis, the impact of concurrent physical frailty and cognitive impairment, that is, cognitive frailty, on prognosis has yet to be fully investigated. The current study sought to investigate the prevalence and prognostic impact of cognitive frailty in elderly patients with HF. METHODS AND
resultsThis study is a sub-analysis of FRAGILE-HF, a prospective multicentre observational study involving patients aged ≥65 years hospitalized for HF. The Fried criteria and Mini-Cog were used to diagnose physical frailty and cognitive impairment, respectively. The association between cognitive frailty and the combined endpoint of mortality and HF rehospitalization within 1 year was then evaluated. Among the 1332 patients identified, 1215 who could be assessed using Mini-Cog and the Fried criteria were included in this study. Among those included, 279 patients (23.0%) had cognitive frailty. During the follow-up 1 year after discharge, 398 combined events were observed. Moreover, cognitive frailty was determined to be associated with a higher incidence of combined events (log-rank: P = 0.0146). This association was retained even after adjusting for other prognostic factors (hazard ratio: 1.55, 95% confidence interval: 1.13-2.13). Furthermore, a sensitivity analysis using grip strength, short physical performance battery, and gait speed to determine physical frailty instead of the Fried criteria showed similar results.
conclusionsThis cohort study found that 23% of elderly patients with HF had cognitive frailty, which was associated with a 1.55-fold greater risk for combined events within 1 year compared with patients without cognitive frailty.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.