Evidence map›Paper›PMID 35181789›Full record

ArticleClinical infectious diseases : an official publication of the Infectious Diseases Society of America2022

Standardized Definitions of In Utero Human Immunodeficiency Virus and Antiretroviral Drug Exposure Among Children.

Amy L Slogrove, Barbara Burmen, Mary Ann Davies, Andrew Edmonds, Elaine J Abrams, Ellen G Chadwick, Tessa Goetghebuer, Lynne M Mofenson, Mary E Paul, Claire Thorne and 3 more

Open access · bronzeAbstract read
In one paragraph

Article in Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed, 2 pooled it
0.6field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 2 syntheses or guidelines pooled it, 11 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 12 institutions in 5 countries.

Amy L SlogroveDepartment of Paediatrics & Child Health, Faculty of Medicine and Health Sciences, Stellenbosch University, Worcester, South Africa.ORCID 0000-0002-8046-9268
Barbara BurmenCentre for Infectious Disease Epidemiology and Research, School of Public Health and Family Medicine, University of Cape Town, South Africa.
Mary Ann DaviesCentre for Infectious Disease Epidemiology and Research, School of Public Health and Family Medicine, University of Cape Town, South Africa.
Andrew EdmondsDepartment of Epidemiology, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.
Elaine J AbramsICAP at Columbia University, Mailman School of Public Health, Columbia University and Vagelos College of Physicians and Surgeons, Columbia University, New York, New York, USA.
Ellen G ChadwickNorthwestern University Feinberg School of Medicine, Chicago, Illinois, USA.
Tessa GoetghebuerDepartment of Pediatrics, CHU St Pierre and Institute for Medical Immunology, Université Libre de Bruxelles, Brussels, Belgium.
Lynne M MofensonResearch Program, Elizabeth Glaser Pediatric AIDS Foundation, Washington D.C., USA.
Mary E PaulDepartment of Pediatrics Immunology, Allergy, and Retrovirology, Baylor College of Medicine, Houston, Texas, USA.
Claire ThorneGreat Ormond Street Institute of Child Health, Faculty of Population Health Sciences, University College London, London, United Kingdom.
Paige L WilliamsDepartment of Biostatistics and Epidemiology, Harvard T.H. Chan School of Public Health, Boston, Massachusetts, USA.
Marissa VicariInternational AIDS Society, Geneva, Switzerlandand.
Kathleen M PowisDepartment of Internal Medicine and Pediatrics, Massachusetts General Hospital, Boston, Massachusetts, USA.
University of Cape Town · ZABaylor College of Medicine · USElizabeth Glaser Pediatric AIDS Foundation · USHarvard University · USICAP Global HealthInternational AIDS Society · CHMassachusetts General Hospital · USNorthwestern University · USStellenbosch University · ZAUniversité Libre de Bruxelles · BEUniversity College London · GBUniversity of North Carolina at Chapel Hill · US

Funding

PHACS - Data and Operations CenterU01HD052102 · NICHD · HARVARD UNIVERSITY (SCH OF PUBLIC HLTH) · PI WILLIAMS, PAIGE L · 2005 to 2019
$242.7M
The Adolescent Master Protocol (AMP) Up Series ProjectP01HD103133 · NICHD · HARVARD UNIVERSITY D/B/A HARVARD SCHOOL OF PUBLIC HEALTH · PI TASSIOPOULOS, KATHERINE K. · 2020 to 2024
$88.3M
The effect of hypertensive disorders in pregnancy and HIV-infection on maternal, birth and infant outcomes in South AfricaK43TW010683 · FIC · STELLENBOSCH UNIVERSITY · PI SLOGROVE, AMY LOUISE · 2017 to 2021
$647k
INFORM - AIDS FREE: A Harmonized Infrastructure For Monitoring Health Outcomes of the "AIDS FREE Generation"R21HD093531 · NICHD · MASSACHUSETTS GENERAL HOSPITAL · PI POWIS, KATHLEEN · 2018 to 2019
$409k
FIC NIH HHS K43 TW010683NICHD NIH HHS P01 HD103133NICHD NIH HHS R21 HD093531NICHD NIH HHS U01 HD052102
6 · The paper itself

Abstract

In countries with high human immunodeficiency virus (HIV) prevalence, up to 30% of pregnant women are living with HIV, with fetal exposure to both HIV and antiretroviral therapy during pregnancy. In addition, pregnant women without HIV but at high risk of HIV acquisition are increasingly receiving HIV preexposure antiretroviral prophylaxis (PrEP). Investments are being made to establish and follow cohorts of children to evaluate the long-term effects of in utero HIV and antiretroviral exposure. Agreement on a key set of definitions for relevant exposures and outcomes is important both for interpreting individual study results and for comparisons across cohorts. Harmonized definitions of in utero HIV and antiretroviral drug (maternal treatment or PrEP) exposure will also facilitate improved classification of these exposures in future observational studies and clinical trials. The proposed definitions offer a uniform approach to facilitate the consistent description and estimation of effects of HIV and antiretroviral exposures on key child health outcomes.

Indexed as

Anti-HIV AgentsHIV InfectionsPre-Exposure ProphylaxisPregnancy Complications, InfectiousAnti-Retroviral AgentsChildFemaleHIVHumansInfectious Disease Transmission, VerticalPregnancyAnti-HIV AgentsAnti-Retroviral AgentsantiretroviraldefinitionHIVin uteropregnancy

Identifiers

PMID35181789
PMCPMC9410726
OpenAlexW4213319539

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.