ArticleMolecular psychiatry2022
Lifespan extension with preservation of hippocampal function in aged system x
Open access · hybridAbstract read
In one paragraph
Article in Molecular psychiatry, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
1.4field-weighted citation impact, top 21% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
14 citing papers in PubMed, 22 citations in OpenAlex.
- Ferroptosis-related stress during aging and its relevance to disease.GeroScience · 2026Review
- Metabolomic signatures of extreme old age: findings from the New England Centenarian Study.GeroScience · 2026Article
- Effects of aging and anti-aging dietary restriction on regulators of the [NADPH]/[NADPFree radical biology & medicine · 2025Review
- Intact corticostriatal function in aged system xTranslational psychiatry · 2025Article
- Differential effects of age and sex on tau pathology propagation in the htau mouse model: A neuropathological and proteomic study.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Article
- METABOLOMIC SIGNATURES OF EXTREME OLD AGE: FINDINGS FROM THE NEW ENGLAND CENTENARIAN STUDY.bioRxiv : the preprint server for biology · 2025Article
- Article
- Citrulline regulates macrophage metabolism and inflammation to counter aging in mice.Science advances · 2025Article
- Disulfidptosis: a new target for central nervous system disease therapy.Frontiers in neuroscience · 2025Review
- Interference with glutamate antiporter system xExperimental physiology · 2024Article
- Cystine/glutamate antiporter xCT controls skeletal muscle glutathione redox, bioenergetics and differentiation.Redox biology · 2024Article
- Aging differentially alters the transcriptome and landscape of chromatin accessibility in the male and female mouse hippocampus.Frontiers in molecular neuroscience · 2024Article
- Tonic extracellular glutamate and ischaemia: glutamate antiporter system xThe Journal of physiology · 2023Article
- Sex- and age-dependent contribution of System xFrontiers in behavioral neuroscience · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
23 authors at 8 institutions in 3 countries.
Lise Verbruggen *Laboratory of Neuro-Aging & Viro-Immunotherapy, Center for Neurosciences (C4N), Vrije Universiteit Brussel (VUB), Brussels, Belgium.
Gamze Ates *Laboratory of Neuro-Aging & Viro-Immunotherapy, Center for Neurosciences (C4N), Vrije Universiteit Brussel (VUB), Brussels, Belgium.ORCID http://orcid.org/0000-0002-9323-3465
Olaya LaraLaboratory of Neuro-Aging & Viro-Immunotherapy, Center for Neurosciences (C4N), Vrije Universiteit Brussel (VUB), Brussels, Belgium.ORCID http://orcid.org/0000-0002-7466-3072
Jolien De MunckLaboratory of Neuro-Aging & Viro-Immunotherapy, Center for Neurosciences (C4N), Vrije Universiteit Brussel (VUB), Brussels, Belgium.ORCID http://orcid.org/0000-0002-5695-7202
Agnès VillersDepartment of Neurosciences, Université de Mons (UMONS), Mons, Belgium.ORCID http://orcid.org/0000-0002-2400-5805
Laura De PauwLaboratory of Neuro-Aging & Viro-Immunotherapy, Center for Neurosciences (C4N), Vrije Universiteit Brussel (VUB), Brussels, Belgium.
Sigrid Ottestad-HansenNeurotransporter Group, Department of Molecular Medicine, Institute of Basic Medical Sciences, University of Oslo, Oslo, Norway.
Sho KobayashiDepartment of Food, Life and Environmental Science, Faculty of Agriculture, Yamagata University, Yamagata, Japan.
Pauline BeckersInstitute of Neuroscience, Université Catholique de Louvain, Brussels, Belgium.ORCID http://orcid.org/0000-0001-9027-2525
Pauline JanssenLaboratory of Neuro-Aging & Viro-Immunotherapy, Center for Neurosciences (C4N), Vrije Universiteit Brussel (VUB), Brussels, Belgium.ORCID http://orcid.org/0000-0003-4564-5665
Hideyo SatoDepartment of Medical Technology, Niigata University, Niigata, Japan.
Yun ZhouNeurotransporter Group, Department of Molecular Medicine, Institute of Basic Medical Sciences, University of Oslo, Oslo, Norway.
Emmanuel HermansInstitute of Neuroscience, Université Catholique de Louvain, Brussels, Belgium.ORCID http://orcid.org/0000-0002-8589-3279
Rose NjeminiFrailty in Ageing research Department, VUB, Brussels, Belgium.ORCID http://orcid.org/0000-0002-8853-6031
Lutgarde ArckensLaboratory of Neuroplasticity and Neuroproteomics, and Leuven Brain Institute (LBI), University of Leuven, Leuven, Belgium.ORCID http://orcid.org/0000-0002-2909-8449
Niels C DanboltNeurotransporter Group, Department of Molecular Medicine, Institute of Basic Medical Sciences, University of Oslo, Oslo, Norway.ORCID http://orcid.org/0000-0003-4227-4520
Dimitri De BundelPharmaceutical Chemistry, Drug Analysis and Drug Information, C4N, VUB, Brussels, Belgium.
Joeri L AertsLaboratory of Neuro-Aging & Viro-Immunotherapy, Center for Neurosciences (C4N), Vrije Universiteit Brussel (VUB), Brussels, Belgium.
Kurt BarbéThe Biostatistics and Medical Informatics Department, VUB, Brussels, Belgium.
Benoit GuillaumeHospital of Jolimont, La Louvière, Belgium.
Laurence RisDepartment of Neurosciences, Université de Mons (UMONS), Mons, Belgium.ORCID http://orcid.org/0000-0002-2140-8297
Eduard BenteaLaboratory of Neuro-Aging & Viro-Immunotherapy, Center for Neurosciences (C4N), Vrije Universiteit Brussel (VUB), Brussels, Belgium.ORCID http://orcid.org/0000-0003-2527-6997
Ann MassieLaboratory of Neuro-Aging & Viro-Immunotherapy, Center for Neurosciences (C4N), Vrije Universiteit Brussel (VUB), Brussels, Belgium. ann.massie@vub.be.ORCID http://orcid.org/0000-0002-8418-5879
Vrije Universiteit Brussel · BEUniversity of Oslo · NOUCLouvain · BEUniversity of Mons · BEHôpital de Jolimont · BEKU Leuven · BENiigata University · JPYamagata University · JP
Funding
No grant is acknowledged in the PubMed record.
Abstract
The cystine/glutamate antiporter system x
Indexed as
Amino Acid Transport System y+CystineAnimalsCysteineGlutamic AcidHippocampusLongevityMaleMiceMice, Inbred C57BLAmino Acid Transport System y+CysteineCystineGlutamic Acid
Identifiers
What OpenQuestion holds
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LicenceCC BY
Read underepoch 390
Registered trials
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.