Evidence map›Paper›PMID 35181738›Full record

ArticleMucosal immunology2022

Neonatal LTβR signaling is required for the accumulation of eosinophils in the inflamed adult mesenteric lymph node.

Conglei Li, Lesley A Ward, Albert Nguyen, Evelyn Lam, Dragos Dasoveanu, Musaddeque Ahmed, Kei Haniuda, Matthew B Buechler, Housheng Hansen He, Burkhard Ludewig and 2 more

Abstract read
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In one paragraph

Article in Mucosal immunology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.2field-weighted citation impact, top 56% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 2 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 4 institutions in 2 countries.

Conglei LiDepartment of Immunology, University of Toronto, Toronto, ON, Canada. liconglei@cuhk.edu.cn.
Lesley A WardDepartment of Immunology, University of Toronto, Toronto, ON, Canada.
Albert NguyenDepartment of Immunology, University of Toronto, Toronto, ON, Canada.
Evelyn LamDepartment of Immunology, University of Toronto, Toronto, ON, Canada.
Dragos DasoveanuDepartment of Immunology, University of Toronto, Toronto, ON, Canada.
Musaddeque AhmedDepartment of Medical Biophysics, Princess Margaret Hospital, University of Toronto, Toronto, ON, Canada.
Kei HaniudaDepartment of Immunology, University of Toronto, Toronto, ON, Canada.
Matthew B BuechlerDepartment of Immunology, University of Toronto, Toronto, ON, Canada.
Housheng Hansen HeDepartment of Medical Biophysics, Princess Margaret Hospital, University of Toronto, Toronto, ON, Canada.
Burkhard LudewigInstitute of Immunobiology, Kantonsspital St. Gallen, St. Gallen, Switzerland.
Kelly Marshall McNagnyBiomedical Research Centre, University of British Columbia, Vancouver, BC, Canada.
Jennifer L GommermanDepartment of Immunology, University of Toronto, Toronto, ON, Canada.
University of Toronto · CAKantonsspital St. Gallen · CHPrincess Margaret Cancer Centre · CAUniversity of British Columbia · CA

Funding

CIHR
6 · The paper itself

Abstract

Although eosinophils are important contributors to mucosal immune responses, mechanisms that regulate their accumulation in mucosal-associated lymphoid tissues remain ill-defined. Combining bone marrow chimeras and pharmacological inhibition approaches, here we find that lymphotoxin-beta receptor (LTβR) signaling during the neonatal period is required for the accumulation of eosinophils in the mesenteric lymph nodes (MLN) during an enteric viral infection in adult male and female mice. We demonstrate that MLN stromal cells express genes that are important for eosinophil migration and survival, such as Ccl-11 (eotaxin-1), Ccl7, Ccl9, and Cxcl2, and that expression of most of these genes is downregulated as a consequence of neonatal LTβR blockade. We also find that neonatal LTβR signaling is required for the generation of a rotavirus-specific IgA antibody response in the adult MLN, but eosinophils are dispensable for this response. Collectively, our studies reveal a role for neonatal LTβR signaling in regulating eosinophil numbers in the adult MLN.

Indexed as

EosinophilsLymph NodesAnimalsFemaleImmunity, MucosalImmunoglobulin ALeukocyte CountMaleMiceImmunoglobulin A

Identifiers

PMID35181738
OpenAlexW4212835079

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.