Evidence map›Paper›PMID 35181725›Full record

ArticleScientific reports2022

Discovery of actinomycin L, a new member of the actinomycin family of antibiotics.

Nataliia V Machushynets, Somayah S Elsayed, Chao Du, Maxime A Siegler, Mercedes de la Cruz, Olga Genilloud, Thomas Hankemeier, Gilles P van Wezel

Abstract read
In one paragraph

Article in Scientific reports, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. NewTheScientificWorldJournal · 2025
    Pooled it
  2. Article
  3. Article
  4. Review
  5. Article
  6. Review
  7. Article
  8. Review
  9. Investigation of antimicrobial synergism of actinomycin derivatives fromTurkish journal of biology = Turk biyoloji dergisi · 2026
    Article
  10. Actinomycin Analogs from Soil-DerivedLife (Basel, Switzerland) · 2025
    Article
  11. Review
  12. Review
  13. Multifunctional metabolites of Streptomyces kunmingensis BS19 from bamboo rhizosphere soil.International microbiology : the official journal of the Spanish Society for Microbiology · 2025
    Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Actinomycins from Soil-InhabitingMolecules (Basel, Switzerland) · 2023
    Article
  20. Discovering New Natural Products Using Metabolomics-Based Approaches.Advances in experimental medicine and biology · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Nataliia V MachushynetsMolecular Biotechnology, Institute of Biology, Leiden University, Sylviusweg 72, 2333 BE, Leiden, The Netherlands.
Somayah S ElsayedMolecular Biotechnology, Institute of Biology, Leiden University, Sylviusweg 72, 2333 BE, Leiden, The Netherlands.
Chao DuMolecular Biotechnology, Institute of Biology, Leiden University, Sylviusweg 72, 2333 BE, Leiden, The Netherlands.
Maxime A SieglerDepartment of Chemistry, The Johns Hopkins University, 3400 North Charles Street, Baltimore, MD, 21218, USA.
Mercedes de la CruzFundación MEDINA, Health Sciences Technology Park, Avda Conocimiento 34, 18016, Granada, Spain.
Olga GenilloudFundación MEDINA, Health Sciences Technology Park, Avda Conocimiento 34, 18016, Granada, Spain.
Thomas HankemeierLeiden Academic Centre for Drug Research (LACDR), Leiden University, Einsteinweg 55, 2333 CC, Leiden, The Netherlands.
Gilles P van WezelMolecular Biotechnology, Institute of Biology, Leiden University, Sylviusweg 72, 2333 BE, Leiden, The Netherlands. g.wezel@biology.leidenuniv.nl.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Streptomycetes are major producers of bioactive natural products, including the majority of the naturally produced antibiotics. While much of the low-hanging fruit has been discovered, it is predicted that less than 5% of the chemical space of natural products has been mined. Here, we describe the discovery of the novel actinomycins L

Indexed as

Anti-Bacterial AgentsBiological ProductsBiosynthetic PathwaysDactinomycinGram-Positive BacteriaHumansortho-AminobenzoatesStreptomyces antibioticusStreptomycetaceaeactinomycin X2anthranilamideAnti-Bacterial AgentsBiological ProductsDactinomycinortho-Aminobenzoates

Identifiers

PMID35181725
PMCPMC8857259

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.