Evidence map›Paper›PMID 35181698›Full record

ArticleScientific reports2022

Iron from nanostructured ferric phosphate: absorption and biodistribution in mice and bioavailability in iron deficient anemic women.

Jeannine Baumgartner, Hans Christian Winkler, Lizelle Zandberg, Siriporn Tuntipopipat, Phatchari Mankong, Cor Bester, Florentine Hilty, Jan Rijn Zeevaart, Sueppong Gowachirapant, Michael B Zimmermann

Registry-linked trialOpen access · goldAbstract read
In one paragraph

Article in Scientific reports, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05826899 (A Stable Isotope Study in Young Iron-depleted Thai Women to Evaluate the Bioavailability of an Oat Protein-based Iron Delivery System), which is not on this map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
2.4field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05826899 nacompletednot on this mapstarted 2023, after this paper: background citation

A Stable Isotope Study in Young Iron-depleted Thai Women to Evaluate the Bioavailability of an Oat Protein-based Iron Delivery System

TypeinterventionalSponsorThe Rainforest CompanyRan2023 to 2024Enrolled52ConditionsBioavailabilityArms54Fe SO4, 57Fe Oat-1, 58Fe Oat-2, 54 FeSO4 + Acai puree with honey, 57Fe Oat-1 + Acai puree with honey
3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 15 citations in OpenAlex.

  1. Trial
  2. Article
  3. Review
  4. Review
  5. Boosting nutritional value: the role of iron fortification in meat and meat products.Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine · 2025
    Review
  6. Article
  7. Review
  8. Iron from the gut: the role of divalent metal transporter 1.Journal of clinical biochemistry and nutrition · 2024
    Article
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 3 countries.

Jeannine Baumgartner *Laboratory of Human Nutrition, Department of Health Sciences and Technology, ETH Zurich, Schmelzbergstrasse 7, 8092, Zurich, Switzerland.
Hans Christian Winkler *Laboratory of Human Nutrition, Department of Health Sciences and Technology, ETH Zurich, Schmelzbergstrasse 7, 8092, Zurich, Switzerland.
Lizelle ZandbergCenter of Excellence in Nutrition, North-West University, Potchefstroom, South Africa.
Siriporn TuntipopipatInstitute of Nutrition, Mahidol University, Salaya, Nakhon Pathom, 73170, Thailand.
Phatchari MankongInstitute of Nutrition, Mahidol University, Salaya, Nakhon Pathom, 73170, Thailand.
Cor BesterDST/NWU Preclinical Drug Development Platform, North-West University, Potchefstroom, South Africa.
Florentine HiltyLaboratory of Human Nutrition, Department of Health Sciences and Technology, ETH Zurich, Schmelzbergstrasse 7, 8092, Zurich, Switzerland.
Jan Rijn ZeevaartDST/NWU Preclinical Drug Development Platform, North-West University, Potchefstroom, South Africa.
Sueppong GowachirapantInstitute of Nutrition, Mahidol University, Salaya, Nakhon Pathom, 73170, Thailand. sueppong.gow@mahidol.ac.th.
Michael B ZimmermannLaboratory of Human Nutrition, Department of Health Sciences and Technology, ETH Zurich, Schmelzbergstrasse 7, 8092, Zurich, Switzerland. michael.zimmermann@hest.ethz.ch.
North-West University · ZAETH Zurich · CHMahidol University · TH

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Food fortification with iron nanoparticles (NPs) could help prevent iron deficiency anemia, but the absorption pathway and biodistribution of iron-NPs and their bioavailability in humans is unclear. Dietary non-heme iron is physiologically absorbed via the divalent metal transporter-1 (DMT1) pathway. Using radio- iron isotope labelling in mice with a partial knockdown of intestine-specific DMT1, we assessed oral absorption and tissue biodistribution of nanostructured ferric phosphate (FePO

Indexed as

AdsorptionAdultAnemia, Iron-DeficiencyAnimalsBiological AvailabilityCation Transport ProteinsDietary SupplementsFemaleFerric CompoundsFerrous CompoundsFood, FortifiedHumansIronIron RadioisotopesMetal NanoparticlesMiceCation Transport ProteinsFerric Compoundsferric phosphateFerrous Compoundsferrous sulfateIronIron RadioisotopesSolute Carrier Family 11, Member 2

Identifiers

PMID35181698
PMCPMC8857185
OpenAlexW4213191211

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.