Evidence map›Paper›PMID 35181678›Full record

ArticleScientific reports2022

Investigation of discordant SARS-CoV-2 RT-PCR results using minimally processed saliva.

Dawn White, Jimmy Gu, Catherine-Jean Steinberg, Deborah Yamamura, Bruno J Salena, Cynthia Balion, Carlos D M Filipe, Alfredo Capretta, Yingfu Li, John D Brennan

Abstract read
In one paragraph

Article in Scientific reports, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed.

  1. Article
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  5. Article
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  8. Critical evaluation of strategies to achieve direct real-time PCR detection of swine pathogens in oral fluids.Journal of veterinary diagnostic investigation : official publication of the American Association of Veterinary Laboratory Diagnosticians, Inc · 2023
    Article
  9. Review
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Dawn WhiteBiointerfaces Institute, McMaster University, Hamilton, ON, L8S 4L8, Canada.
Jimmy GuDepartment of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, ON, L8N 3Z5, Canada.
Catherine-Jean SteinbergDepartment of Medicine, McMaster University, Hamilton, ON, L8N 3Z5, Canada.
Deborah YamamuraMichael DeGroote Institute of Infectious Disease Research, McMaster University, Hamilton, ON, L8N 3Z5, Canada.
Bruno J SalenaDepartment of Medicine, McMaster University, Hamilton, ON, L8N 3Z5, Canada.
Cynthia BalionDepartment of Pathology and Molecular Medicine, McMaster University, Hamilton, ON, L8N 3Z5, Canada.
Carlos D M FilipeDepartment of Chemical Engineering, McMaster University, Hamilton, ON, L8S 4M1, Canada.
Alfredo CaprettaBiointerfaces Institute, McMaster University, Hamilton, ON, L8S 4L8, Canada.
Yingfu LiBiointerfaces Institute, McMaster University, Hamilton, ON, L8S 4L8, Canada. liying@mcmaster.ca.
John D BrennanBiointerfaces Institute, McMaster University, Hamilton, ON, L8S 4L8, Canada. brennanj@mcmaster.ca.

Funding

CIHR 172718
6 · The paper itself

Abstract

Saliva is an attractive sample for coronavirus disease 2019 testing due its ease of collection and amenability to detect viral RNA with minimal processing. Using a direct-to-RT-PCR method with saliva self-collected from confirmed COVID-19 positive volunteers, we observed 32% false negative results. Confirmed negative and healthy volunteer samples spiked with 10

Indexed as

COVID-19 Nucleic Acid TestingFalse Negative ReactionsHealthy VolunteersHumansPoint-of-Care TestingSalivaSARS-CoV-2

Identifiers

PMID35181678
PMCPMC8857222

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.