Evidence map›Paper›PMID 35181676›Full record

ArticleCell death & disease2022

HOXA-AS2 contributes to regulatory T cell proliferation and immune tolerance in glioma through the miR-302a/KDM2A/JAG1 axis.

Chuanhong Zhong, Bei Tao, Xianglong Li, Wei Xiang, Lilei Peng, Tangming Peng, Ligang Chen, Xiangguo Xia, Jian You, Xiaobo Yang

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell death & disease, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed, 2 pooled it
3.2field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed, 2 syntheses or guidelines pooled it, 36 citations in OpenAlex.

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  5. Mechanistic insights into the lncRNA-Notch signaling axis in tumors.Frontiers in cell and developmental biology · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 2 countries.

Chuanhong ZhongNeurosurgery Department, the Affiliated Hospital of Southwest Medical University, 646000, Luzhou, P. R. China.
Bei TaoRheumatism Department, the Affiliated Hospital of Southwest Medical University, 646000, Luzhou, P. R. China.
Xianglong LiNeurosurgery Department, the Affiliated Hospital of Southwest Medical University, 646000, Luzhou, P. R. China.
Wei XiangNeurosurgery Department, the Affiliated Hospital of Southwest Medical University, 646000, Luzhou, P. R. China.
Lilei PengNeurosurgery Department, the Affiliated Hospital of Southwest Medical University, 646000, Luzhou, P. R. China.
Tangming PengNeurosurgery Department, the Affiliated Hospital of Southwest Medical University, 646000, Luzhou, P. R. China.
Ligang ChenNeurosurgery Department, the Affiliated Hospital of Southwest Medical University, 646000, Luzhou, P. R. China.
Xiangguo XiaNeurosurgery Department, the Affiliated Hospital of Southwest Medical University, 646000, Luzhou, P. R. China.
Jian YouNeurosurgery Department, the Affiliated Hospital of Southwest Medical University, 646000, Luzhou, P. R. China. jianyou123456@163.com.ORCID http://orcid.org/0000-0002-1461-640X
Xiaobo YangNeurosurgery Department, the Affiliated Hospital of Southwest Medical University, 646000, Luzhou, P. R. China. xbyang710@swmu.edu.cn.ORCID http://orcid.org/0000-0002-6151-9784
Affiliated Hospital of Southwest Medical University · CNSouthwest Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Long non-coding RNAs (lncRNAs) have been manifested to manipulate diverse biological processes, including tumor-induced immune tolerance. Thus, we aimed in this study to identify the expression pattern of lncRNA homeobox A cluster antisense RNA 2 (HOXA-AS2) in glioma and decipher its role in immune tolerance and glioma progression. We found aberrant upregulation of lncRNA HOXA-AS2, lysine demethylase 2A (KDM2A), and jagged 1 (JAG1) and a downregulation of microRNA-302a (miR-302a) in glioma specimens. Next, RNA immunoprecipitation, chromatin immunoprecipitation, and dual-luciferase reporter gene assay demonstrated that lncRNA HOXA-AS2 upregulated KDM2A expression by preventing miR-302a from binding to its 3'untranslated region. The functional experiments suggested that lncRNA HOXA-AS2 could promote regulatory T (T

Indexed as

F-Box ProteinsGliomaRNA, AntisenseRNA, Long NoncodingAnimalsCell Line, TumorCell ProliferationGene Expression Regulation, NeoplasticHumansImmune ToleranceJagged-1 ProteinJumonji Domain-Containing Histone DemethylasesMiceMicroRNAsF-Box ProteinsJAG1 protein, humanJagged-1 ProteinJumonji Domain-Containing Histone DemethylasesKDM2A protein, humanMicroRNAsMIRN302A microRNA, humanRNA, AntisenseRNA, Long Noncoding

Identifiers

PMID35181676
PMCPMC8857186
OpenAlexW4213261137

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.