ArticleNature communications2022
The insect somatostatin pathway gates vitellogenesis progression during reproductive maturation and the post-mating response.
Article in Nature communications, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 50 citations in OpenAlex.
- Sexual identity of Akh neurons shapes Nucb1-dependent metabolic and reproductive plasticity.iScience · 2026Article
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- A hormone-to-neuropeptide pathway inhibits sexual receptivity in immatureProceedings of the National Academy of Sciences of the United States of America · 2025Article
- Gut-Brain Dialogues in Fruit Fly (Current drug targets · 2025Review
- The GPCR A35 regulates fecundity ofFrontiers in insect science · 2025Article
- Gut-to-brain regulation ofProceedings of the National Academy of Sciences of the United States of America · 2024Article
- A sexually transmitted sugar orchestrates reproductive responses to nutritional stress.Nature communications · 2024Article
- Somatostatin signalling coordinates energy metabolism allocation to reproduction in zebrafish.BMC biology · 2024Article
- Altered circadian rhythm, sleep, andProceedings of the National Academy of Sciences of the United States of America · 2024Article
- Integration of photoperiodic and temperature cues by the circadian clock to regulate insect seasonal adaptations.Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology · 2024Review
- Gut-to-brain regulation ofbioRxiv : the preprint server for biology · 2024Article
- Long-term neuropeptide modulation of female sexual drive via the TRP channel inProceedings of the National Academy of Sciences of the United States of America · 2024Article
- Redox mechanisms of environmental toxicants on male reproductive function.Frontiers in cell and developmental biology · 2024Review
- The molecular mechanisms of diapause and diapause-like reversible arrest.Biochemical Society transactions · 2023Review
- Review
- CRUMB: a shiny-based app to analyze rhythmic feeding inF1000Research · 2023Article
- Crosstalk between Nutrition, Insulin, Juvenile Hormone, and Ecdysteroid Signaling in the Classical Insect Model,International journal of molecular sciences · 2022Article
- Review
Corrections and comments
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Authors and funding
5 authors at 4 institutions in 4 countries.
Funding
Abstract
Vitellogenesis (yolk accumulation) begins upon eclosion and continues through the process of sexual maturation. Upon reaching sexual maturity, vitellogenesis is placed on hold until it is induced again by mating. However, the mechanisms that gate vitellogenesis in response to developmental and reproductive signals remain unclear. Here, we have identified the neuropeptide allatostatin-C (AstC)-producing neurons that gate both the initiation of vitellogenesis that occurs post-eclosion and its re-initiation post-mating. During sexual maturation, the AstC neurons receive excitatory inputs from Sex Peptide Abdominal Ganglion (SAG) neurons. In mature virgin females, high sustained activity of SAG neurons shuts off vitellogenesis via continuous activation of the AstC neurons. Upon mating, however, Sex Peptide inhibits SAG neurons, leading to deactivation of the AstC neurons. As a result, this permits both JH biosynthesis and the progression of vitellogenesis in mated females. Our work has uncovered a central neural circuit that gates the progression of oogenesis.
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