Evidence map›Paper›PMID 35181641›Full record

ArticleJournal of immunology (Baltimore, Md. : 1950)2022

E-Protein Inhibition in ILC2 Development Shapes the Function of Mature ILC2s during Allergic Airway Inflammation.

Gilad Barshad, Lauren M Webb, Hung-An Ting, Oyebola O Oyesola, Oluomachi G Onyekwere, James J Lewis, Edward J Rice, Macy K Matheson, Xiao-Hong Sun, Jakob von Moltke and 2 more

Open access · hybridAbstract read
In one paragraph

Article in Journal of immunology (Baltimore, Md. : 1950), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.5field-weighted citation impact, top 40% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 3 institutions in 1 country.

Gilad BarshadBaker Institute for Animal Health, Cornell University College of Veterinary Medicine, Ithaca, NY.ORCID 0000-0001-7845-7658
Lauren M WebbDepartment of Immunology, University of Washington, Seattle, WA; lwebb2@uw.edu etwojno@uw.edu.ORCID 0000-0002-1903-7570
Hung-An TingDepartment of Immunology, University of Washington, Seattle, WA.
Oyebola O OyesolaDepartment of Immunology, University of Washington, Seattle, WA.
Oluomachi G OnyekwereBaker Institute for Animal Health, Cornell University College of Veterinary Medicine, Ithaca, NY.
James J LewisBaker Institute for Animal Health, Cornell University College of Veterinary Medicine, Ithaca, NY.
Edward J RiceBaker Institute for Animal Health, Cornell University College of Veterinary Medicine, Ithaca, NY.
Macy K MathesonDepartment of Immunology, University of Washington, Seattle, WA.ORCID 0000-0002-6113-0787
Xiao-Hong SunArthritis and Clinical Immunology Program, Oklahoma Medical Research Foundation, Oklahoma City, OK.ORCID 0000-0003-0572-2662
Jakob von MoltkeDepartment of Immunology, University of Washington, Seattle, WA.ORCID 0000-0003-2894-3353
Charles G DankoBaker Institute for Animal Health, Cornell University College of Veterinary Medicine, Ithaca, NY.ORCID 0000-0002-1999-7125
Elia D Tait WojnoDepartment of Immunology, University of Washington, Seattle, WA; lwebb2@uw.edu etwojno@uw.edu.ORCID 0000-0003-2822-296X
University of Washington · USCornell University · USOklahoma Medical Research Foundation · US

Funding

Role of the prostaglandin D2 receptor CRTH2 in helminth-induced type 2 inflammation in the intestine.R01AI130379 · NIAID · UNIVERSITY OF WASHINGTON · PI Elia D Tait Wojno · 2017 to 2026
$3.5M
Evolution of Chromatin Architecture and Transcriptional Regulation in MammalsR01HG010346 · NHGRI · CORNELL UNIVERSITY · PI DANKO, CHARLES GRAHE, SIEPEL, ADAM CHARLES · 2019 to 2022
$2.7M
Exploring the thymic origin of group 2 innate lymphoid cellsR01AI126851 · NIAID · OKLAHOMA MEDICAL RESEARCH FOUNDATION · PI SUN, XIAO-HONG · 2016 to 2020
$2.7M
Sensing of helminths by tuft cellsDP2AI136596 · NIAID · UNIVERSITY OF WASHINGTON · PI VON MOLTKE, JAKOB H. · 2017 to 2017
$2.6M
The Notch Signaling Pathway Regulates Basophil Responses During Helminth InfectionR01AI132708 · NIAID · UNIVERSITY OF WASHINGTON · PI TAIT WOJNO, ELIA D · 2017 to 2021
$2.1M
Acquisition of BD FACSymphony A3 Lite Flow CytometerS10OD024979 · OD · UNIVERSITY OF WASHINGTON · PI BLACK, MICHELE C · 2020 to 2020
$344k
Prostaglandin regulation of type 2 inflammationK22AI116729 · NIAID · CORNELL UNIVERSITY · PI TAIT WOJNO, ELIA D · 2016 to 2017
$267k
NHGRI NIH HHS R01 HG010346NIAID NIH HHS DP2 AI136596NIAID NIH HHS K22 AI116729NIAID NIH HHS R01 AI126851NIAID NIH HHS R01 AI130379NIAID NIH HHS R01 AI132708NIH HHS S10 OD024979
6 · The paper itself

Abstract

E-protein transcription factors limit group 2 innate lymphoid cell (ILC2) development while promoting T cell differentiation from common lymphoid progenitors. Inhibitors of DNA binding (ID) proteins block E-protein DNA binding in common lymphoid progenitors to allow ILC2 development. However, whether E-proteins influence ILC2 function upon maturity and activation remains unclear. Mice that overexpress ID1 under control of the thymus-restricted proximal

Indexed as

Adaptor Proteins, Signal TransducingAllergensAnimalsAntigens, DermatophagoidesAsthmaCell DifferentiationChromatinCytokinesDNA-Binding ProteinsFemaleInhibitor of Differentiation Protein 1Lectins, C-TypeLungMaleMiceMice, Inbred C57BLAdaptor Proteins, Signal TransducingAllergensAntigens, DermatophagoidesChromatinCytokinesDNA-Binding ProteinsIdb1 protein, mouseInhibitor of Differentiation Protein 1Klrg1 protein, mouseLectins, C-TypeReceptors, ImmunologicSh2d2a protein, mouseTranscription Factor AP-1Transcription Factors

Identifiers

PMID35181641
PMCPMC8881320
OpenAlexW4213124983

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.