Evidence map›Paper›PMID 35181606›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2022

Mass cytometry reveals single-cell kinetics of cytotoxic lymphocyte evolution in CMV-infected renal transplant patients.

Kenichi Ishiyama, Janice Arakawa-Hoyt, Oscar A Aguilar, Izabella Damm, Parhom Towfighi, Tara Sigdel, Stanley Tamaki, Joel Babdor, Matthew H Spitzer, Elaine F Reed and 3 more

Open access · greenAbstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed
5.5field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 36 citations in OpenAlex.

  1. Article
  2. Observational
  3. Review
  4. Article
  5. CITE-Seq Analysis Reveals a Differential Natural Killer CellInternational journal of molecular sciences · 2025
    Article
  6. Immune surveillance of cytomegalovirus in tissues.Cellular & molecular immunology · 2024
    Review
  7. Review
  8. Article
  9. Review
  10. Article
  11. Expansion of effector memory Vδ2Frontiers in immunology · 2024
    Article
  12. Article
  13. Review
  14. Single-cell profiling aligns CD56Frontiers in immunology · 2024
    Article
  15. Article
  16. Article
  17. Review
  18. Article
  19. Human CD8Immune network · 2023
    Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 2 institutions in 1 country.

Kenichi IshiyamaDepartment of Microbiology and Immunology, University of California, San Francisco, CA 94143.ORCID 0000-0002-9377-2098
Janice Arakawa-HoytDepartment of Microbiology and Immunology, University of California, San Francisco, CA 94143.
Oscar A AguilarDepartment of Microbiology and Immunology, University of California, San Francisco, CA 94143.
Izabella DammDepartment of Surgery, University of California, San Francisco, CA 94143.
Parhom TowfighiDepartment of Surgery, University of California, San Francisco, CA 94143.
Tara SigdelDepartment of Surgery, University of California, San Francisco, CA 94143.
Stanley TamakiParnassus Flow Cytometry Core, University of California, San Francisco, CA 94143.
Joel BabdorDepartment of Microbiology and Immunology, University of California, San Francisco, CA 94143.
Matthew H SpitzerDepartment of Microbiology and Immunology, University of California, San Francisco, CA 94143.
Elaine F ReedDepartment of Pathology and Laboratory Medicine, University of California, Los Angeles, CA 90095.
Minnie M SarwalDepartment of Surgery, University of California, San Francisco, CA 94143.
Lewis L LanierDepartment of Microbiology and Immunology, University of California, San Francisco, CA 94143; lewis.lanier@ucsf.edu.ORCID 0000-0003-1308-3952
CMV Systems Immunobiology Group
University of California, San Francisco · USUniversity of California, Los Angeles · US

Funding

Research BaseP30DK063720 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI VAISSE, CHRISTIAN · 2003 to 2019
$21.8M
Project 3: Mapping the Evolution of Chronic Transplant Injury in the Context of CMV InfectionU19AI128913 · NIAID · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI REED, ELAINE F, SARWAL, MINNIE M · 2017 to 2021
$11.2M
UCSF DVS CyTOF Mass CytometerS10OD018040 · OD · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI LANIER, LEWIS LEE · 2014 to 2014
$600k
NIAID NIH HHS U19 AI128913NIDDK NIH HHS P30 DK063720NIH HHS S10 OD018040
6 · The paper itself

Abstract

Cytomegalovirus (CMV) infection is associated with graft rejection in renal transplantation. Memory-like natural killer (NK) cells expressing NKG2C and lacking FcεRIγ are established during CMV infection. Additionally, CD8

Indexed as

AdultCD8-Positive T-LymphocytesCell SeparationCytomegalovirusCytomegalovirus InfectionsFemaleFlow CytometryGraft RejectionHumansKidney TransplantationKiller Cells, NaturalKineticsLymphocyte ActivationMaleMiddle AgedNK Cell Lectin-Like Receptor Subfamily CKLRC2 protein, humanNK Cell Lectin-Like Receptor Subfamily Ccytomegaloviruscytotoxic lymphocytemass cytometryNK cellrenal transplantation

Identifiers

PMID35181606
PMCPMC8872722
OpenAlexW4212908527

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.