Evidence map›Paper›PMID 35181570›Full record

ArticleClinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association2022

International Consensus Recommendations for Eosinophilic Gastrointestinal Disease Nomenclature.

Evan S Dellon, Nirmala Gonsalves, J Pablo Abonia, Jeffrey A Alexander, Nicoleta C Arva, Dan Atkins, Stephen E Attwood, Marcus K H Auth, Dominique D Bailey, Luc Biederman and 81 more

Abstract readConsensus Statement
In one paragraph

Article in Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 93 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
93citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

93 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Guideline
  2. Pooled it
  3. Trial
  4. Article
  5. Update on biologic and small molecules treatments in pediatric allergic diseases.Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology · 2026
    Review
  6. Article
  7. Article
  8. Behind the scenes: Primary immunodeficiencies in pediatric eosinophilic gastrointestinal diseases.Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology · 2026
    Article
  9. Article
  10. Article
  11. Eosinophilic gastrointestinal diseases.Nature reviews. Disease primers · 2026
    Review
  12. Article
  13. Article
  14. Review
  15. Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. Review

33 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

91 authors.

Evan S DellonCenter for Esophageal Diseases and Swallowing and Center for Gastrointestinal Biology and Disease, Division of Gastroenterology and Hepatology, Department of Medicine, University of North Carolina School of Medicine, Chapel Hill, North Carolina. Electronic address: edellon@med.unc.edu.
Nirmala GonsalvesDivision of Gastroenterology and Hepatology, Northwestern University Feinberg School of Medicine, Chicago, Illinois.
J Pablo AboniaDivision of Allergy and Immunology, Department of Pediatrics, Cincinnati Children's Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, Ohio.
Jeffrey A AlexanderDivision of Gastroenterology, Mayo Clinic Rochester, Minnesota.
Nicoleta C ArvaDepartment of Pathology, Ann and Robert H. Lurie Children's Hospital of Chicago, Northwestern University Feinberg School of Medicine, Chicago, Illinois.
Dan AtkinsSection of Pediatric Allergy and Immunology, Children's Hospital Colorado, University of Colorado School of Medicine, Aurora, Colorado.
Stephen E AttwoodDepartment of Health Services Research, Durham University, Durham, United Kingdom.
Marcus K H AuthDepartment of Paediatric Gastroenterology, Hepatology and Nutrition, Alder Hey Children's NHS Foundation Trust and University of Liverpool, Liverpool, United Kingdom.
Dominique D BaileyDivision of Pediatric Gastroenterology, Hepatology, and Nutrition, Department of Pediatrics, Columbia University Irving Medical Center, New York, New York; Division of Digestive and Liver Disease, Department of Medicine, Columbia University Irving Medical Center, New York, New York; Columbia Center for Human Development, Columbia University Irving Medical Center, New York, New York.
Luc BiedermanDepartment of Gastroenterology and Hepatology, University Hospital Zurich, Zurich, Switzerland.
Carine BlanchardDepartment of Gastro-Intestinal Health, Immunology group, Nestlé Institute of Health Sciences, Nestlé Research, Société des Produits Nestlé S.A., Lausanne, Switzerland.
Peter A BonisDivision of Gastroenterology, Tufts University School of Medicine, Boston, Massachusetts.
Paroma BoseDivision of Pediatric Gastroenterology, Hepatology, and Nutrition, Riley Hospital for Children and Community Health Network, Indiana University School of Medicine, Indianapolis, Indianapolis.
Albert J BredenoordDepartment of Gastroenterology, Amsterdam University Medical Center, Amsterdam, the Netherlands.
Joy W ChangDivision of Gastroenterology, Department of Internal Medicine, University of Michigan, Ann Arbor, MichiganI.
Mirna ChehadeMount Sinai Center for Eosinophilic Disorders, Icahn School of Medicine at Mount Sinai, New York, New York.
Margaret H CollinsDivision of Pathology and Laboratory Medicine, Department of Pediatrics, Cincinnati Children's Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, Ohio.
Carlo Di LorenzoDivision of Gastroenterology, Hepatology and Nutrition, Nationwide Children's Hospital, Columbus, Ohio.
Jorge Amil DiasHospital Lusiadas, Porto, Portugal.
Ranjan DohilDivision on Pediatric Gastroenterology, Rady's Children's Hospital, University of California, San Diego, San Diego, California.
Christophe DupontRamsay Group, Marcel Sembat Clinic, Paris Descartes University, Paris, France.
Gary W FalkDivision of Gastroenterology, Perelman School of Medicine, University of Pennsylvania Philadelphia, Pennsylvania.
Cristina T FerreiraHospital Santo Antônio, Federal University of Health Sciences of Porto Alegre, Porto Alegre, Brazil.
Adam T FoxPaediatric Allergy, Guy's & St. Thomas' Hospitals NHS Foundation Trust, London, United Kingdom.
Robert M GentaDivision of Gastroenterology, Department of Pathology and Medicine, Baylor College of Medicine, Houston, Texas; Inform Diagnostics, Irving, Texas.
Thomas GreuterDepartment of Gastroenterology and Hepatology, University Hospital Zurich, Zurich, Switzerland; Division of Gastroenterology and Hepatology, University Hospital Lausanne, Lausanne, Switzerland.
Sandeep K GuptaDivision of Pediatric Gastroenterology, Hepatology, and Nutrition, Riley Hospital for Children and Community Health Network, Indiana University School of Medicine, Indianapolis, Indianapolis.
Ikuo HiranoDivision of Gastroenterology and Hepatology, Northwestern University Feinberg School of Medicine, Chicago, Illinois.
Girish S HiremathDivision of Pediatric Gastroenterology, Hepatology, and Nutrition, Monroe Carell Jr. Children's Hospital at Vanderbilt, Vanderbilt University Medical Center, Nashville, Tennessee.
Jennifer L Horsley-SilvaDivision of Gastroenterology and Hepatology, Mayo Clinic, Phoenix, Arizona.
Shunji IshiharaDepartment of Internal Medicine II, Shimane University Faculty of Medicine, Shimane, Japan.
Norihisa IshimuraDepartment of Internal Medicine II, Shimane University Faculty of Medicine, Shimane, Japan.
Elizabeth T JensenDepartment of Epidemiology and Prevention, Wake Forest School of Medicine, Winston-Salem, North Carolina.
Carolina Gutiérrez-JunqueraPediatric Gastroenterology Unit, University Hospital Puerta de Hierro Majadahonda, Autonomous University of Madrid, Majadahonda, Spain.
David A KatzkaDivision of Gastroenterology, Mayo Clinic Rochester, Minnesota.
Paneez KhouryHuman Eosinophil Section, National Institute of Allergy and Infectious Diseases/National Institutes of Health, Bethesda, Maryland.
Yoshikazu KinoshitaHyogo Prefectural Harima-Himeji General Medical Center, Himeji, Japan.
Kara L KliewerDivision of Allergy and Immunology, Department of Pediatrics, Cincinnati Children's Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, Ohio.
Sibylle KoletzkoDepartment of Pediatrics, Dr. von Hauner Children's Hospital, University Hospital, LMU Munich, Munich, Germany; Department of Pediatrics, Gastroenterology and Nutrition, School of Medicine Collegium Medicum University of Warmia and Mazury, Olsztyn, Poland.
John LeungDivision of Gastroenterology, Tufts University School of Medicine, Boston, Massachusetts.
Chris A LiacourasCenter for Pediatric Eosinophilic Disorders, Division of Gastroenterology, Hepatology and Nutrition, Children's Hospital of Philadelphia, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania.
Alfredo J LucendoDepartment of Gastroenterology, Hospital General de Tomelloso, Instituto de Investigación Sanitaria Princesa, Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas, Tomelloso, Spain.
Lisa J MartinDepartment of Pediatrics, Cincinnati Children's Hospital, University of Cincinnati College of Medicine, Cincinnati, Ohio.
Emily C McGowanDivision of Allergy and Immunology, University of Virginia School of Medicine, Charlottesville, Virginia.
Calies Menard-KatcherDigestive Health Institute, Children's Hospital Colorado, Aurora, Colorado; Gastrointestinal Eosinophilic Diseases Program, University of Colorado School of Medicine, Aurora, Colorado.
David C MetzDivision of Gastroenterology, Perelman School of Medicine, University of Pennsylvania Philadelphia, Pennsylvania.
Talya L MillerSwedish Medical Center, Seattle, Washington.
Fouad J MoawadDivision of Gastroenterology and Hepatology, Scripps Clinic, La Jolla, California.
Amanda B MuirCenter for Pediatric Eosinophilic Disorders, Division of Gastroenterology, Hepatology and Nutrition, Children's Hospital of Philadelphia, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania.
Vincent A MukkadaDivision of Gastroenterology, Hepatology, and Nutrition, Department of Pediatrics, Cincinnati Children's Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, Ohio.
Simon MurchWarwick University Medical School, Coventry, United Kingdom.
Quan M NhuDivision of Gastroenterology and Hepatology, Scripps Clinic, La Jolla, California; Department of Molecular Medicine, Scripps Research Institute, San Diego, California; Division of Allergy and Immunology, University of California, San Diego, La Jolla, California.
Ichiro NomuraDivision of Eosinophilic Gastrointestinal Disorders, Allergy Center, National Center for Child Health and Development, Tokyo, Japan.
Samuel NurkoCenter for Motility and Functional Gastrointestinal Disorders, Boston Children's Hospital, Boston, Massachusetts.
Yoshikazu OhtsukaDepartment of Pediatrics and Adolescent Medicine, Juntendo University Graduate School of Medicine, Tokyo, Japan.
Salvatore OlivaPediatric Digestive Endoscopy, Pediatric Gastroenterology and Liver Unit, Maternal and Child Health Department, University Hospital, University of Rome, Rome, Italy.
Rok OrelUniversity Children's Hospital Ljubljana, Faculty of Medicine, University of Ljubljana, Slovenia.
Alexandra PapadopoulouDivision of Gastroenterology and Hepatology, Children's Hospital Agia Sofia, First Department of Pediatrics, University of Athens, Athens, Greece.
Dhyanesh A PatelCenter for Esophageal Disorders, Vanderbilt University Medical Center, Nashville, Tennessee.
Robert D PesekDivision of Allergy and Immunology, Department of Pediatrics, Arkansas Children's Hospital, University of Arkansas for Medical Sciences, Little Rock, Arkansas.
Kathryn A PetersonDivision of Gastroenterology, University of Utah, Salt Lake City, Utah.
Hamish PhilpottDepartment of Gastroenterology, Lyell McEwin Hospital, University of Adelaide, Adelaide, Australia.
Philip E PutnamDivision of Gastroenterology, Hepatology, and Nutrition, Department of Pediatrics, Cincinnati Children's Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, Ohio.
Joel E RichterMorsani College of Medicine, University of South Florida, Tampa, Florida.
Rachel RosenAerodigestive Center, Boston Children's Hospital, Boston, Massachusetts.
Melanie A RuffnerDivision of Allergy and Immunology, Children's Hospital of Philadelphia, Department of Pediatrics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania.
Ekaterina SafroneevaInstitute of Social and Preventive Medicine, University of Bern, Bern, Switzerland.
Philipp SchreinerDepartment of Gastroenterology and Hepatology, University Hospital Zurich, Zurich, Switzerland.
Alain SchoepferDivision of Gastroenterology and Hepatology, University Hospital Lausanne, Lausanne, Switzerland.
Shauna R SchroederDivision of Gastroenterology, Hepatology, and Nutrition, Phoenix Children's Hospital, Phoenix, Arizona.
Neil ShahPortland Hospital, London, United Kingdom; Reckitt Healthcare, Slough, United Kingdom.
Rhonda F SouzaDivision of Gastroenterology and Center for Esophageal Diseases, Baylor Scott & White Center for Esophageal Research, Baylor University Medical Center, Baylor Scott & White Research Institute, Dallas, Texas.
Stuart J SpechlerDivision of Gastroenterology and Center for Esophageal Diseases, Baylor Scott & White Center for Esophageal Research, Baylor University Medical Center, Baylor Scott & White Research Institute, Dallas, Texas.
Jonathan M SpergelDivision of Allergy and Immunology, Children's Hospital of Philadelphia, Department of Pediatrics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania.
Alex StraumannDepartment of Gastroenterology and Hepatology, University Hospital Zurich, Zurich, Switzerland.
Nicholas J TalleySchool of Medicine and Public Health, University of Newcastle, Newcastle, Australia; National Health and Medical Research Council Centre of Research Excellence on Digestive Health, Newcastle, Australia; Hunter Medical Research Institute, New Lambton Heights, Australia.
Nikhil ThaparDepartment of Gastroenterology, Hepatology and Liver Transplant, Queensland Children's Hospital, School of Medicine, University of Queensland, Brisbane, Australia; Woolworths Centre for Child Nutrition Research, Queensland University of Technology, Brisbane, Australia.
Yvan VandenplasKidZ Health Castle, Vrije Universiteit Brussel, Brussels, Belgium.
Rajitha D VenkateshDivision of Gastroenterology, Hepatology and Nutrition, Nationwide Children's Hospital, Columbus, Ohio.
Mario C VieiraCenter for Pediatric Gastroenterology, Hospital Pequeno Príncipe, Curitiba, Brazil.
Ulrike von ArnimDepartment of Gastroenterology, Hepatology and Infectious Diseases, University Hospital Magdeburg, Magdeburg, Germany.
Marjorie M WalkerDepartment of Pathology, College of Health, Medicine and Wellbeing, Faculty of Health and Medicine, University of Newcastle Callaghan, Australia.
Joshua B WechslerDivision of Gastroenterology, Hepatology, and Nutrition, Ann and Robert H. Lurie Children's Hospital of Chicago, Chicago, Illinois.
Barry K WershilDivision of Gastroenterology, Hepatology, and Nutrition, Ann and Robert H. Lurie Children's Hospital of Chicago, Chicago, Illinois.
Benjamin L WrightDivision of Allergy, Asthma, and Clinical Immunology, Department of Medicine, Mayo Clinic Arizona, Scottsdale, Arizona; Section of Allergy and Immunology, Division of Pulmonology, Phoenix Children's Hospital, Phoenix, Arizona.
Yoshiyuki YamadaDepartment of Pediatrics, Tokai University School of Medicine, Kanagawa, Japan.
Guang-Yu YangDepartment of Pathology, Northwestern University Feinberg School of Medicine, Chicago, Illinois.
Noam ZevitInstitute of Gastroenterology, Hepatology, and Nutrition, Schneider Children's Medical Center of Israel, Sackler Faculty of Medicine, Tel-Aviv University, Petah-Tikva, Israel.
Marc E RothenbergDivision of Allergy and Immunology, Department of Pediatrics, Cincinnati Children's Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, Ohio.
Glenn T FurutaDigestive Health Institute, Children's Hospital Colorado, Aurora, Colorado; Gastrointestinal Eosinophilic Diseases Program, University of Colorado School of Medicine, Aurora, Colorado.
Seema S AcevesDivision of Allergy, Immunology, and Rheumatology, Departments of Pediatrics and Medicine, Rady Children's Hospital, University of California San Diego, San Diego, California.

Funding

The Impact of COVID-19 on People Living with Rare Diseases and Their FamiliesU2CTR002818 · NCATS · CINCINNATI CHILDRENS HOSP MED CTR · PI Michal Kouril · 2019 to 2026
$51.2M
Eosinophils and Eosinophil Activation in the Pathogenesis of Human DiseaseZIAAI001130 · NIAID · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · PI KLION, AMY · 2010 to 2025
$22.5M
TRAINING (CAREER DEVELOPMENT) COMPONENTU54AI117804 · NIAID · CINCINNATI CHILDRENS HOSP MED CTR · PI Nirmala P Gonsalves · 2014 to 2026
$18.5M
The Organoid and Cell Culture CoreP30DK132710 · NIDDK · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI Robert F. Schwabe · 2022 to 2026
$7.2M
NCATS NIH HHS U2C TR002818NIAID NIH HHS U54 AI117804NIDDK NIH HHS P30 DK132710
6 · The paper itself

Abstract

BACKGROUND &

aimsSubstantial heterogeneity in terminology used for eosinophilic gastrointestinal diseases (EGIDs), particularly the catchall term "eosinophilic gastroenteritis," limits clinical and research advances. We aimed to achieve an international consensus for standardized EGID nomenclature.

methodsThis consensus process utilized Delphi methodology. An initial naming framework was proposed and refined in iterative fashion, then assessed in a first round of Delphi voting. Results were discussed in 2 consensus meetings, and the framework was updated and reassessed in a second Delphi vote, with a 70% threshold set for agreement.

resultsOf 91 experts participating, 85 (93%) completed the first and 82 (90%) completed the second Delphi surveys. Consensus was reached on all but 2 statements. "EGID" was the preferred umbrella term for disorders of gastrointestinal (GI) tract eosinophilic inflammation in the absence of secondary causes (100% agreement). Involved GI tract segments will be named specifically and use an "Eo" abbreviation convention: eosinophilic gastritis (now abbreviated EoG), eosinophilic enteritis (EoN), and eosinophilic colitis (EoC). The term "eosinophilic gastroenteritis" is no longer preferred as the overall name (96% agreement). When >2 GI tract areas are involved, the name should reflect all of the involved areas.

conclusionsThis international process resulted in consensus for updated EGID nomenclature for both clinical and research use. EGID will be the umbrella term, rather than "eosinophilic gastroenteritis," and specific naming conventions by location of GI tract involvement are recommended. As more data are developed, this framework can be updated to reflect best practices and the underlying science.

Indexed as

EnteritisEosinophiliaEosinophilic EsophagitisGastritisHumansClassificationDelphiEosinophilic GastroenteritisEosinophilic Gastrointestinal DiseaseNomenclature

Identifiers

PMID35181570
PMCPMC9378753

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.