Evidence map›Paper›PMID 35181146›Full record

ReviewTrends in biotechnology2022

Engineering tissue morphogenesis: taking it up a Notch.

Laura A Tiemeijer, Sami Sanlidag, Carlijn V C Bouten, Cecilia M Sahlgren

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Trends in biotechnology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Optogenetic Rescue Reveals Spatiotemporal Rules of Germ-Layer Patterning.bioRxiv : the preprint server for biology · 2025
    Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Review
  10. Article
  11. Article
  12. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Laura A TiemeijerFaculty for Science and Engineering, Biosciences, Åbo Akademi University, Turku, Finland; Department of Biomedical Engineering, Eindhoven University of Technology, Eindhoven, The Netherlands; Institute for Complex Molecular Systems (ICMS), Eindhoven University of Technology, Eindhoven, The Netherlands; InFLAMES Research Flagship Center, Åbo Akademi University, Turku, Finland.
Sami SanlidagFaculty for Science and Engineering, Biosciences, Åbo Akademi University, Turku, Finland; InFLAMES Research Flagship Center, Åbo Akademi University, Turku, Finland; Turku Bioscience Centre, Åbo Akademi University and University of Turku, Turku, Finland.
Carlijn V C BoutenDepartment of Biomedical Engineering, Eindhoven University of Technology, Eindhoven, The Netherlands; Institute for Complex Molecular Systems (ICMS), Eindhoven University of Technology, Eindhoven, The Netherlands. Electronic address: c.v.c.bouten@tue.nl.
Cecilia M SahlgrenFaculty for Science and Engineering, Biosciences, Åbo Akademi University, Turku, Finland; Department of Biomedical Engineering, Eindhoven University of Technology, Eindhoven, The Netherlands; Institute for Complex Molecular Systems (ICMS), Eindhoven University of Technology, Eindhoven, The Netherlands; InFLAMES Research Flagship Center, Åbo Akademi University, Turku, Finland; Turku Bioscience Centre, Åbo Akademi University and University of Turku, Turku, Finland. Electronic address: cecilia.sahlgren@abo.fi.

Funding

European Research Council 771168
6 · The paper itself

Abstract

Recreating functional tissues through bioengineering strategies requires steering of complex cell fate decisions. Notch, a juxtacrine signaling pathway, regulates cell fate and controls cellular organization with local precision. The engineering-friendly characteristics of the Notch pathway provide handles for engineering tissue patterning and morphogenesis. We discuss the physiological significance and mechanisms of Notch signaling with an emphasis on its potential use for engineering complex tissues. We highlight the current state of the art of Notch activation and provide a view on the design aspects, opportunities, and challenges in modulating Notch for tissue-engineering strategies. We propose that finely tuned control of Notch contributes to the generation of tissues with accurate form and functionality.

Indexed as

Receptors, NotchSignal TransductionCell DifferentiationMorphogenesisTissue EngineeringReceptors, Notchligand immobilizationmorphogenesisNotch signalingNotch signaling modulationtissue patterning

Identifiers

PMID35181146
PMCPMC7613405

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.