Evidence map›Paper›PMID 35180864›Full record

ArticleJournal of neuroinflammation2022

Choroid plexus-selective inactivation of adenosine A

Wu Zheng, Yijia Feng, Zhenhai Zeng, Mengqian Ye, Mengru Wang, Xin Liu, Ping Tang, Huiping Shang, Xiaoting Sun, Xiangxiang Lin and 6 more

Open access · goldAbstract read
In one paragraph

Article in Journal of neuroinflammation, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed
4.2field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 33 citations in OpenAlex.

  1. Review
  2. Review
  3. Aberrant adenosine ANature communications · 2025
    Article
  4. Protection From Demyelination by the Novel Adenosine Dual AJournal of cellular and molecular medicine · 2025
    Article
  5. Review
  6. Adenosine AJournal of the American Heart Association · 2025
    Article
  7. Article
  8. Review
  9. Article
  10. Adenosine ACell communication and signaling : CCS · 2025
    Article
  11. Article
  12. Choroid Plexus Pathophysiology.Annual review of pathology · 2025
    Review
  13. Review
  14. Intrinsic ecto-5'-Nucleotidase/AMolecular neurobiology · 2024
    Article
  15. Article
  16. Review
  17. Review
  18. Article
  19. Article
  20. Blocking the IFN-gamma signal in the choroid plexus confers resistance to experimental autoimmune encephalomyelitis.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 1 institution in 2 countries.

Wu Zheng *Molecular Neuropharmacology Laboratory, School of Optometry and Ophthalmology and Eye Hospital, Wenzhou Medical University, Wenzhou, 325000, China.
Yijia Feng *Department of Neurology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, 325000, Zhejiang, China.
Zhenhai ZengMolecular Neuropharmacology Laboratory, School of Optometry and Ophthalmology and Eye Hospital, Wenzhou Medical University, Wenzhou, 325000, China.
Mengqian YeDepartment of Neurology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, 325000, Zhejiang, China.
Mengru WangMolecular Neuropharmacology Laboratory, School of Optometry and Ophthalmology and Eye Hospital, Wenzhou Medical University, Wenzhou, 325000, China.
Xin LiuMolecular Neuropharmacology Laboratory, School of Optometry and Ophthalmology and Eye Hospital, Wenzhou Medical University, Wenzhou, 325000, China.
Ping TangMolecular Neuropharmacology Laboratory, School of Optometry and Ophthalmology and Eye Hospital, Wenzhou Medical University, Wenzhou, 325000, China.
Huiping ShangMolecular Neuropharmacology Laboratory, School of Optometry and Ophthalmology and Eye Hospital, Wenzhou Medical University, Wenzhou, 325000, China.
Xiaoting SunMolecular Neuropharmacology Laboratory, School of Optometry and Ophthalmology and Eye Hospital, Wenzhou Medical University, Wenzhou, 325000, China.
Xiangxiang LinDepartment of Neurology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, 325000, Zhejiang, China.
Muran WangMolecular Neuropharmacology Laboratory, School of Optometry and Ophthalmology and Eye Hospital, Wenzhou Medical University, Wenzhou, 325000, China.
Zhengzheng LiDepartment of Neurology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, 325000, Zhejiang, China.
Yiyun WengDepartment of Neurology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, 325000, Zhejiang, China.
Wei GuoMolecular Neuropharmacology Laboratory, School of Optometry and Ophthalmology and Eye Hospital, Wenzhou Medical University, Wenzhou, 325000, China.
Sergii VakalMolecular Neuropharmacology Laboratory, School of Optometry and Ophthalmology and Eye Hospital, Wenzhou Medical University, Wenzhou, 325000, China.
Jiang-Fan ChenMolecular Neuropharmacology Laboratory, School of Optometry and Ophthalmology and Eye Hospital, Wenzhou Medical University, Wenzhou, 325000, China. chenjf555@gmail.com.ORCID http://orcid.org/0000-0002-0446-3956
Wenzhou Medical University · CN

Funding

national key research and development program of china 2016YFC1306600national key research and development program of china 2016YFC1306602national natural science foundation of china 31800903national natural science foundation of china 81630040National Natural Science Foundation of China 82150710558natural science foundation of zhejiang province LQ18H090007wenzhou science and technology project Y2020426
6 · The paper itself

Abstract

backgroundMultiple sclerosis (MS) is one of the most common autoimmune disorders characterized by the infiltration of immune cells into the brain and demyelination. The unwanted immunosuppressive side effect of therapeutically successful natalizumab led us to focus on the choroid plexus (CP), a key site for the first wave of immune cell infiltration in experimental autoimmune encephalomyelitis (EAE), for the control of immune cells trafficking. Adenosine A

methodsIn the EAE model, we assessed A

resultsWe found the specific upregulation of A

conclusionThese findings define the CP niche as one of the primary sites of A

Indexed as

Encephalomyelitis, Autoimmune, ExperimentalAdenosineAnimalsChoroid PlexusMiceMice, Inbred C57BLReceptor, Adenosine A2AAdenosineReceptor, Adenosine A2AAdenosine A2A receptorChoroid plexusImmune infiltrationMultiple sclerosis

Identifiers

PMID35180864
PMCPMC8855604
OpenAlexW4225769484

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.