ArticleNeuroImage. Clinical2022
FLAIR MRI biomarkers of the normal appearing brain matter are related to cognition.
Article in NeuroImage. Clinical, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 19 citations in OpenAlex.
- A global effort to benchmark predictive models and reveal mechanistic diversity in long-term stroke outcomes.bioRxiv : the preprint server for biology · 2025Article
- Developmental Curves of the Paediatric Brain Using FLAIR MRI Texture Biomarkers.Canadian Association of Radiologists journal = Journal l'Association canadienne des radiologistes · 2025Article
- High-quality multimodal MRI with simultaneous EEG using conductive ink and polymer-thick film nets.Journal of neural engineering · 2024Article
- The contribution of the meningeal immune interface to neuroinflammation in traumatic brain injury.Journal of neuroinflammation · 2024Review
- Stratifying vascular disease patients into homogeneous subgroups using machine learning and FLAIR MRI biomarkers.Npj imaging · 2024Article
- Cognitive function mediates the relationship between age and anaesthesia-induced oscillatory-specific alpha power.Brain communications · 2024Article
- Comparing the Efficacy of Two Cognitive Screening Tools in Identifying Gray and White Matter Brain Damage among Older Adults.Journal of aging research · 2024Article
- Brain Age Estimation on a Dementia Cohort Using FLAIR MRI Biomarkers.AJNR. American journal of neuroradiology · 2023Article
- Brain Maturation Patterns on Normalized FLAIR MR Imaging in Children and Adolescents.AJNR. American journal of neuroradiology · 2023Article
- Assessment of white matter hyperintensity severity using multimodal magnetic resonance imaging.Brain communications · 2023Article
- Alzheimer's and vascular disease classification using regional texture biomarkers in FLAIR MRI.NeuroImage. Clinical · 2023Article
- Synthesis of diffusion-weighted MRI scalar maps from FLAIR volumes using generative adversarial networks.Frontiers in neuroinformatics · 2023Article
- Detecting conversion from mild cognitive impairment to Alzheimer's disease using FLAIR MRI biomarkers.NeuroImage. Clinical · 2023Article
- Article
- Delusional Severity Is Associated with Abnormal Texture in FLAIR MRI.Brain sciences · 2022Article
Corrections and comments
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Authors and funding
10 authors at 4 institutions in 1 country.
Funding
Abstract
A novel biomarker panel was proposed to quantify macro and microstructural biomarkers from the normal-appearing brain matter (NABM) in multicentre fluid-attenuation inversion recovery (FLAIR) MRI. The NABM is composed of the white and gray matter regions of the brain, with the lesions and cerebrospinal fluid removed. The primary hypothesis was that NABM biomarkers from FLAIR MRI are related to cognitive outcome as determined by MoCA score. There were three groups of features designed for this task based on 1) texture: microstructural integrity (MII), macrostructural damage (MAD), microstructural damage (MID), 2) intensity: median, skewness, kurtosis and 3) volume: NABM to ICV volume ratio. Biomarkers were extracted from over 1400 imaging volumes from more than 87 centres and unadjusted ANOVA analysis revealed significant differences in means of the MII, MAD, and NABM volume biomarkers across all cognitive groups. In an adjusted ANCOVA model, a significant relationship between MoCA categories was found that was dependent on subject age for MII, MAD, intensity, kurtosis and NABM volume biomarkers. These results demonstrate that structural brain changes in the NABM are related to cognitive outcome (with different relationships depending on the age of the subjects). Therefore these biomarkers have high potential for clinical translation. As a secondary hypothesis, we investigated whether texture features from FLAIR MRI can quantify microstructural changes related to how "structured" or "damaged" the tissue is. Based on correlation analysis with diffusion weighted MRI (dMRI), it was shown that FLAIR MRI texture biomarkers (MII and MAD) had strong correlations to mean diffusivity (MD) which is related to tissue degeneration in the GM and WM regions. As FLAIR MRI is routinely collected for clinical neurological examinations, novel biomarkers from FLAIR MRI could be used to supplement current clinical biomarkers and for monitoring disease progression. Biomarkers could also be used to stratify patients into homogeneous disease subgroups for clinical trials, or to learn more about mechanistic development of dementia disease.
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