Evidence map›Paper›PMID 35180288›Full record

ArticleAge and ageing2022

The association between the inflammatory response following surgery and post-operative delirium in older oncological patients: a prospective cohort study.

Baukje Brattinga, Matthijs Plas, Jacoba M Spikman, Abraham Rutgers, Jacco J de Haan, Anthony R Absalom, Hanneke van der Wal-Huisman, Geertruida H de Bock, Barbara L van Leeuwen

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Age and ageing, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers, 10 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
33citing papers in PubMed, 10 pooled it
3.7field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

33 citing papers in PubMed, 10 syntheses or guidelines pooled it, 47 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Pooled it
  5. Pooled it
  6. Pooled it
  7. Pooled it
  8. Pooled it
  9. Pooled it
  10. Pooled it
  11. Review
  12. Article
  13. Article
  14. Review
  15. Article
  16. Review
  17. Article
  18. Acute kidney injury and postoperative delirium.Journal of biomedical research · 2025
    Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Baukje BrattingaUniversity of Groningen, University Medical Center Groningen, Department of Surgery, 9700 RB Groningen, The Netherlands.
Matthijs PlasUniversity of Groningen, University Medical Center Groningen, Department of Surgery, 9700 RB Groningen, The Netherlands.
Jacoba M SpikmanUniversity of Groningen, University Medical Center Groningen, Department of Neurology, 9700 RB Groningen, The Netherlands.
Abraham RutgersUniversity of Groningen, University Medical Center Groningen, Department of Rheumatology and Clinical Immunology, 9700 RB Groningen, The Netherlands.
Jacco J de HaanUniversity of Groningen, University Medical Center Groningen, Department of Medical Oncology, 9700 RB Groningen, The Netherlands.
Anthony R AbsalomUniversity of Groningen, University Medical Center Groningen, Department of Anesthesiology, 9700 RB Groningen, The Netherlands.
Hanneke van der Wal-HuismanUniversity of Groningen, University Medical Center Groningen, Department of Surgery, 9700 RB Groningen, The Netherlands.
Geertruida H de BockUniversity of Groningen, University Medical Center Groningen, Department of Epidemiology, 9700 RB Groningen, The Netherlands.
Barbara L van LeeuwenUniversity of Groningen, University Medical Center Groningen, Department of Surgery, 9700 RB Groningen, The Netherlands.
University Medical Center Groningen · NLUniversity of Groningen · NL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionPost-operative delirium (POD) is associated with increased morbidity and mortality rates in older patients. Neuroinflammation, the activation of the intrinsic immune system of the brain, seems to be one of the mechanisms behind the development of POD. The aim of this study was to explore the association between the perioperative inflammatory response and the development of POD in a cohort of older oncological patients in need for surgery.

methodsIn this prospective cohort study, patients 65 years and older in need for oncologic surgery were included. Inflammatory markers C-reactive protein (CRP), interleukin-1 beta (IL-1β), IL-6, IL10 and Neutrophil gelatinase-associated lipocalin (NGAL) were measured in plasma samples pre- and post-operatively. Delirium Observation Screening Scale (DOS) was used as screening instrument for POD in the first week after surgery. In case of positive screening, diagnosis of POD was assessed by a clinician.

resultsBetween 2010 and 2016, plasma samples of 311 patients with median age of 72 years (range 65-89) were collected. A total of 38 (12%) patients developed POD in the first week after surgery. The perioperative increase in plasma levels of IL-10 and NGAL were associated with POD in multivariate logistic regression analysis (OR 1.33 [1.09-1.63] P = 0.005 and OR 1.30 [1.03-1.64], P = 0.026, respectively). The biomarkers CRP, IL-1β and IL-6 were not significantly associated with POD.

conclusionsIncreased surgery-evoked inflammatory responses of IL-10 and NGAL are associated with the development of POD in older oncological patients. The outcomes of this study contribute to understanding the aetiology of neuroinflammation and the development of POD.

Indexed as

DeliriumPostoperative ComplicationsAgedAged, 80 and overCohort StudiesC-Reactive ProteinHumansProspective StudiesC-Reactive Proteincancerinflammatory responseneuroinflammationolder patientsolder peoplePost-operative delirium

Identifiers

PMID35180288
PMCPMC9160877
OpenAlexW4206623209

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.