Evidence map›Paper›PMID 35180118›Full record

ArticleJournal of Alzheimer's disease : JAD2022

Late-Onset Alcohol Abuse as a Presenting Symptom of Neurodegenerative Diseases.

Elisa de Paula França Resende, Robin Ketelle, Anna Karydas, Isabel Allen, Lea T Grinberg, Salvatore Spina, William W Seeley, David C Perry, Bruce Miller, Georges Naasan

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of Alzheimer's disease : JAD, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.7field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Alcohol Use Disorder and Dementia: A Review.Alcohol research : current reviews · 2024
    Review
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 3 countries.

Elisa de Paula França ResendeHospital das Clínicas da Universidade Federal de Minas Gerais - EBSERH, Belo Horizonte, Brazil.
Robin KetelleMemory and Aging Center, Department of Neurology, University of California, San Francisco, CA, USA.
Anna KarydasMemory and Aging Center, Department of Neurology, University of California, San Francisco, CA, USA.
Isabel AllenGlobal Brain Health Institute based at University of California, San Francisco, CA, USA and Trinity College, Dublin, Ireland.
Lea T GrinbergGlobal Brain Health Institute based at University of California, San Francisco, CA, USA and Trinity College, Dublin, Ireland.
Salvatore SpinaGlobal Brain Health Institute based at University of California, San Francisco, CA, USA and Trinity College, Dublin, Ireland.
William W SeeleyMemory and Aging Center, Department of Neurology, University of California, San Francisco, CA, USA.
David C PerryMemory and Aging Center, Department of Neurology, University of California, San Francisco, CA, USA.
Bruce MillerGlobal Brain Health Institute based at University of California, San Francisco, CA, USA and Trinity College, Dublin, Ireland.
Georges NaasanGlobal Brain Health Institute based at University of California, San Francisco, CA, USA and Trinity College, Dublin, Ireland.
University of California, San Francisco · USUniversity Memory and Aging Center · USGlobal Brain Health Institute · USMount Sinai Hospital · US

Funding

TDP-43 Loss-of-Function: Biology to BiomarkersP01AG019724 · NIA · UNIVERSITY OF PENNSYLVANIA · PI Jennifer Merrilees · 2002 to 2026
$67.2M
Research Education ComponentP30AG062422 · NIA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Katherine P Rankin · 2019 to 2026
$36.9M
PrPSc SPECIFIC INTERACTION WITH NOVEL PrP-Fc FUSION PROTEINSP50AG023501 · NIA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI MILLER, BRUCE L · 2004 to 2018
$27.1M
Clinical Features and Neuropathological Basis of Sleep Wake Behavior in Alzheimer's and PSPR01AG060477 · NIA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Lea Tenenholz Grinberg, Thomas C Neylan · 2019 to 2026
$8.2M
Diagnostic and prognostic certainty in behavioral variant frontotemporal dementiaR01AG062758 · NIA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI PERRY, DAVID C · 2020 to 2025
$4.0M
Reward processing in genetic frontotemporal dementia and mood disordersR01AG059794 · NIA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI PERRY, DAVID C · 2019 to 2023
$4.0M
Neuropathological changes underlying clinical heterogeneity in Alzheimer diseaseK24AG053435 · NIA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI GRINBERG, LEA TENENHOLZ · 2016 to 2025
$1.8M
Reward processing in frontotemporal dementiaK23AG045289 · NIA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI PERRY, DAVID C · 2014 to 2018
$880k
Neuropathological basis of brain network dysfunctionK08AG052648 · NIA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI SPINA, SALVATORE · 2016 to 2020
$852k
NIA NIH HHS K08 AG052648NIA NIH HHS K23 AG045289NIA NIH HHS K24 AG053435NIA NIH HHS P01 AG019724NIA NIH HHS P30 AG062422NIA NIH HHS P50 AG023501NIA NIH HHS R01 AG059794NIA NIH HHS R01 AG060477NIA NIH HHS R01 AG062758
6 · The paper itself

Abstract

backgroundThe association between lifetime alcohol abuse and a higher risk to develop dementia is well known. However, it is unknown whether older adults who begin abusing alcohol late in life have an underlying neurodegenerative disease.

objectiveIdentify the frequency of lifelong alcohol abuse (L-AA), late-onset alcohol abuse (LO-AA), and alcohol abuse as a first symptom of dementia (AA-FS) in patients with neurodegenerative diseases.

methodsCross-sectional retrospective study of patients evaluated at an academic referral center with a clinical diagnosis of behavioral variant frontotemporal dementia (bvFTD), Alzheimer-type dementia (AD), and semantic variant primary progressive aphasia (svPPA) (n = 1,518). The presence of alcohol abuse was screened with the National Alzheimer's Coordinating Center questionnaire. L-AA was defined as onset < 40 years, LO-AA as onset ≥40 years, and AA-FS was defined when the abuse started within the first three years from symptom onset.

resultsThe frequency of LO-AA was 2.2% (n = 33/1,518). LO-AA was significantly more frequent in patients with bvFTD than AD (7.5%, n = 13/173 versus 1.3%, n = 16/1,254, CI:1.0;11.4%), but not svPPA (4.4%, n = 4/91, CI: -4.4;10.7%). Similarly, AA-FS was more frequent in bvFTD patients than AD (5.7%, n = 10/173 versus 0.7%, n = 9/1,254, CI:0.5%;9.5%), but not svPPA (2.2%, n = 2/91, CI:-2.4;9.1%).

conclusionLO-AA can be a presenting symptom of dementia, especially bvFTD. Alcohol abuse onset later in life should prompt a clinical investigation into the possibility of an underlying neurodegenerative process because delay in diagnosis and treatment may increase patient and caregiver burden. The results need to be interpreted with caution due to the limitations of the study.

Indexed as

AlcoholismAlzheimer DiseaseFrontotemporal DementiaNeurodegenerative DiseasesAgedCross-Sectional StudiesHumansNeuropsychological TestsRetrospective StudiesAlcohol-related problemsAlzheimer’s dementiadementiafrontotemporal dementia

Identifiers

PMID35180118
PMCPMC9090138
OpenAlexW4213060939

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.