Evidence map›Paper›PMID 35179978›Full record

ArticleAmerican journal of physiology. Heart and circulatory physiology2022

Circulating lymphocyte trafficking to the bone marrow contributes to lymphopenia in myocardial infarction.

Yonggang Ma, Xiaoyuan Yang, Nuria Villalba, Victor Chatterjee, Amanda Reynolds, Sam Spence, Mack H Wu, Sarah Y Yuan

Open access · greenAbstract read
In one paragraph

Article in American journal of physiology. Heart and circulatory physiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
2.6field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 26 citations in OpenAlex.

  1. Article
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  3. Aging diminishes thymic output, reduces naive T cells, promotes memory T-cell accumulation, and impairs thymic regeneration.American journal of physiology. Regulatory, integrative and comparative physiology · 2026
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  12. Glucocorticoids impair T lymphopoiesis after myocardial infarction.American journal of physiology. Heart and circulatory physiology · 2024
    Article
  13. The heart-bone connection: relationships between myocardial infarction and osteoporotic fracture.American journal of physiology. Heart and circulatory physiology · 2024
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Yonggang MaDepartment of Molecular Pharmacology and Physiology, University of South Florida Morsani College of Medicine, Tampa, Florida.ORCID 0000-0003-1711-0639
Xiaoyuan YangDepartment of Molecular Pharmacology and Physiology, University of South Florida Morsani College of Medicine, Tampa, Florida.
Nuria VillalbaDepartment of Molecular Pharmacology and Physiology, University of South Florida Morsani College of Medicine, Tampa, Florida.
Victor ChatterjeeDepartment of Molecular Pharmacology and Physiology, University of South Florida Morsani College of Medicine, Tampa, Florida.
Amanda ReynoldsDepartment of Molecular Pharmacology and Physiology, University of South Florida Morsani College of Medicine, Tampa, Florida.
Sam SpenceDepartment of Molecular Pharmacology and Physiology, University of South Florida Morsani College of Medicine, Tampa, Florida.
Mack H WuDepartment of Surgery, University of South Florida Morsani College of Medicine, Tampa, Florida.
Sarah Y YuanDepartment of Molecular Pharmacology and Physiology, University of South Florida Morsani College of Medicine, Tampa, Florida.
University of South Florida · US

Funding

Vascular Barrier Leakage in InflammationR35HL150732 · NHLBI · UNIVERSITY OF SOUTH FLORIDA · PI Sarah Y Yuan · 2020 to 2026
$6.2M
Endothelial glycocalyx shedding in septic injuryR01GM142110 · NIGMS · UNIVERSITY OF SOUTH FLORIDA · PI WU, MACK H, YUAN, SARAH Y · 2022 to 2025
$1.9M
Molecular Control of Gut Permeability in TraumaI01BX000799 · VA · VA NORTHERN CALIFORNIA HEALTH CARE SYS · PI WU, MACK H · 2011 to 2023
–
BLRD Research Career Scientist Award ApplicationIK6BX004210 · VA · JAMES A. HALEY VA MEDICAL CENTER · PI WU, MACK H · 2018 to 2025
–
BLRD VA I01 BX000799BLRD VA IK6 BX004210NHLBI NIH HHS R35 HL150732NIGMS NIH HHS R01 GM142110
6 · The paper itself

Abstract

Some patients with myocardial infarction (MI) exhibit lymphopenia, a reduction in blood lymphocyte count. Moreover, lymphopenia inversely correlates with patient prognosis. The objective of this study was to elucidate the underlying mechanisms that cause lymphopenia after MI. Multiparameter flow cytometric analysis demonstrated that MI induced profound B and T lymphopenia in a mouse model, peaking at

Indexed as

LymphopeniaMyocardial InfarctionAnimalsBone MarrowHumansLymphocyte CountLymphocytesMicebone marrowglucocorticoidslymphocytelymphopeniamyocardial infarction

Identifiers

PMID35179978
PMCPMC8934671
OpenAlexW4212800940

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.