Evidence map›Paper›PMID 35179975›Full record

ArticleAmerican journal of physiology. Heart and circulatory physiology2022

Impact of angiotensin II receptor antagonism on the sex-selective dysregulation of cardiovascular function induced by in utero dexamethasone exposure.

L Madhavpeddi, B Hammond, D L Carbone, P Kang, R J Handa, T M Hale

Open access · greenAbstract read
In one paragraph

Article in American journal of physiology. Heart and circulatory physiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
5.3field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 15 citations in OpenAlex.

  1. Impacts of prenatal resiquimod exposure during late gestation on rat offspring development and behavior.American journal of physiology. Regulatory, integrative and comparative physiology · 2026
    Article
  2. Article
  3. Article
  4. Prenatal dexamethasone programs autonomic dysregulation in female rats.American journal of physiology. Heart and circulatory physiology · 2025
    Article
  5. Programming the heart: prenatal glucocorticoids and sex-specific cardiovascular risk.American journal of physiology. Heart and circulatory physiology · 2025
    Article
  6. Article
  7. Sex as a biological variable for cardiovascular physiology.American journal of physiology. Heart and circulatory physiology · 2024
    Review
  8. Guidelines on the use of sex and gender in cardiovascular research.American journal of physiology. Heart and circulatory physiology · 2024
    Review
  9. Article
  10. Article
  11. Review
  12. Sexually dimorphic effects of SARM1 deletion on cardiac NADAmerican journal of physiology. Heart and circulatory physiology · 2022
    Article
  13. Case Report: A novelFrontiers in genetics · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

L MadhavpeddiDepartment of Basic Medical Sciences, University of Arizona College of Medicine, Phoenix, Arizona.
B HammondDepartment of Basic Medical Sciences, University of Arizona College of Medicine, Phoenix, Arizona.
D L CarboneDepartment of Basic Medical Sciences, University of Arizona College of Medicine, Phoenix, Arizona.
P KangDepartment of Basic Medical Sciences, University of Arizona College of Medicine, Phoenix, Arizona.ORCID 0000-0002-6857-2932
R J HandaDepartment of Basic Medical Sciences, University of Arizona College of Medicine, Phoenix, Arizona.
T M HaleDepartment of Basic Medical Sciences, University of Arizona College of Medicine, Phoenix, Arizona.ORCID 0000-0002-5066-1216
University of Arizona · US

Funding

Sex Differences in Major Depression, Part II: Impact of Prenatal Immune, Autonomic and Neurovascular FunctionU54MH118919 · NIMH · MASSACHUSETTS GENERAL HOSPITAL · PI STUART A. TOBET · 2020 to 2026
$12.7M
NIMH NIH HHS U54 MH118919
6 · The paper itself

Abstract

In utero exposure to glucocorticoids in late gestation programs changes in cardiovascular function. The objective of this study was to determine the degree to which angiotensin II mediates sex-biased changes in autonomic function as well as basal and stress-responsive cardiovascular function following in utero glucocorticoid exposure. Pregnant rats were administered the synthetic glucocorticoid dexamethasone (Dex; 0.4 mg/kg/day sc) or vehicle on

Indexed as

Angiotensin II Type 2 Receptor BlockersPrenatal Exposure Delayed EffectsAngiotensin IIAnimalsBlood PressureDexamethasoneFemaleMalePregnancyRatsReceptor, Angiotensin, Type 1Angiotensin IIAngiotensin II Type 2 Receptor BlockersDexamethasoneReceptor, Angiotensin, Type 1autonomic nervous systemblood pressuredexamethasoneprenatal programmingsex differences

Identifiers

PMID35179975
PMCPMC8934675
OpenAlexW4213375737

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.