ArticleScience immunology2022
An IL-9-pulmonary macrophage axis defines the allergic lung inflammatory environment.
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Article in Science immunology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 47 papers.
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47citing papers in PubMed
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47 citing papers in PubMed, 68 citations in OpenAlex.
- IL-9R/Arg1 pathway promotes polyamine metabolism in human airway macrophages.The Journal of allergy and clinical immunology · 2026Article
- IL-9 Is Essential for ILC2-Mediated but Not Th2- and Th17-Cell-Mediated Allergic Airway Inflammation in Mice.European journal of immunology · 2026Article
- An early protective effect of IL-9 in murine systemic lupus erythematosus.ImmunoHorizons · 2026Article
- Liver Kinase B1 in CD11cAdvanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Phagocytotic impairment of tissue-resident alveolar macrophages by diesel particulates drives pulmonary surfactant accumulation.Advanced biotechnology · 2026Article
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- Macrophage-intrinsic and IL-9-dependent arginine metabolism promotes lung tumor growth.Journal of immunology (Baltimore, Md. : 1950) · 2026Article
- The Pleiotropic IL-9 Network in Asthma Pathogenesis and Targeted Therapy.Journal of inflammation research · 2026Review
- Cellular metabolism in Th9, Th17, and Treg cell differentiation.International immunology · 2025Review
- The role of the IL-9‒NLRP3 axis in insulin resistance and adipose tissue inflammation during diet-induced obesity.Cellular & molecular immunology · 2025Article
- Targeting Arginine Metabolism in Immune Cells for the Treatment of Pulmonary Inflammatory Diseases.Current allergy and asthma reports · 2025Review
- The immunology of asthma.Nature immunology · 2025Review
- The immunology of asthma and chronic rhinosinusitis.Nature reviews. Immunology · 2025Review
- Sexual dimorphism of lung immune-regulatory units imprint biased pulmonary fibrosis.Cellular & molecular immunology · 2025Article
- Highly immunogenic DNA/LION nanocarrier vaccine potently activates lymph nodes inducing long-lasting immunity in macaques.iScience · 2025Article
- Temporal and Spatial Metabolic Shifts Revealing the Transition from Ulcerative Colitis to Colitis-Associated Colorectal Cancer.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- IL-33 signaling is dispensable for the IL-10-induced enhancement of mast cell responses during food allergy.Frontiers in immunology · 2025Article
- Serum IL-18R1 and its effect on immune cell infiltration in asthma.American journal of translational research · 2025Article
- Interleukin-9 promotes EMT-mediated PMArchives of toxicology · 2024Article
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Authors and funding
21 authors at 8 institutions in 4 countries.
Yongyao FuDepartment of Microbiology and Immunology, Indiana University School of Medicine, Indianapolis, IN 46202, USA.ORCID 0000-0002-0739-0035
Jocelyn WangDepartment of Microbiology and Immunology, Indiana University School of Medicine, Indianapolis, IN 46202, USA.ORCID 0000-0003-0016-3136
Baohua ZhouDepartment of Pediatrics and Herman B Wells Center for Pediatric Research, Indiana University School of Medicine, Indianapolis, IN 46202, USA.ORCID 0000-0003-1156-4517
Abigail PajulasDepartment of Microbiology and Immunology, Indiana University School of Medicine, Indianapolis, IN 46202, USA.
Hongyu GaoDepartment of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, IN 46202, USA.
Baskar RamdasDepartment of Pediatrics and Herman B Wells Center for Pediatric Research, Indiana University School of Medicine, Indianapolis, IN 46202, USA.
Byunghee KohDepartment of Microbiology and Immunology, Indiana University School of Medicine, Indianapolis, IN 46202, USA.ORCID 0000-0003-3554-4449
Benjamin J UlrichDepartment of Microbiology and Immunology, Indiana University School of Medicine, Indianapolis, IN 46202, USA.ORCID 0000-0002-2729-1798
Shuangshuang YangDepartment of Microbiology and Immunology, Indiana University School of Medicine, Indianapolis, IN 46202, USA.ORCID 0000-0003-0871-6356
Reuben KapurDepartment of Pediatrics and Herman B Wells Center for Pediatric Research, Indiana University School of Medicine, Indianapolis, IN 46202, USA.ORCID 0000-0003-2225-1700
Jean-Christophe RenauldLudwig Institute for Cancer Research, Experimental Medicine Unit, Université Catholique de Louvain, Brussels 1200, Belgium.ORCID 0000-0003-1736-2131
Sophie PaczesnyDepartment of Microbiology and Immunology, Medical University of South Carolina, 171 Ashley Avenue, Charleston, SC 29425, USA.ORCID 0000-0001-5571-2775
Yunlong LiuDepartment of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, IN 46202, USA.ORCID 0000-0002-2699-626X
Robert M TigheDivision of Pulmonary, Allergy, and Critical Care Medicine, Duke University Medical Center, Durham, NC 27710, USA.ORCID 0000-0002-3465-9861
Paula Licona-LimónDepartamento de Biologia Celular y del Desarrollo, Instituto de Fisiologia Celular, Universidad Nacional Autónoma de México, 04510 Mexico City, Mexico.ORCID 0000-0002-7692-8900
Richard A FlavellDepartment of Immunobiology, Yale University School of Medicine, New Haven, CT 06510, USA.ORCID 0000-0003-4461-0778
Shogo TakatsukaDivision of Molecular Biology, Research Institute for Biomedical Sciences (RIBS), Tokyo University of Science, Noda, Japan.ORCID 0000-0003-3258-0129
Daisuke KitamuraDivision of Molecular Biology, Research Institute for Biomedical Sciences (RIBS), Tokyo University of Science, Noda, Japan.
Robert S TepperDepartment of Pediatrics and Herman B Wells Center for Pediatric Research, Indiana University School of Medicine, Indianapolis, IN 46202, USA.ORCID 0000-0003-3322-5903
Jie SunDepartment of Medicine, Mayo Clinic, Rochester, MN 55905, USA.ORCID 0000-0002-2347-4511
Mark H KaplanDepartment of Microbiology and Immunology, Indiana University School of Medicine, Indianapolis, IN 46202, USA.ORCID 0000-0002-2923-8245
Indiana University School of MedicineTokyo University of Science · JPDuke Medical Center · USLudwig Cancer Research · BEMayo Clinic in Arizona · USMedical University of South Carolina · USUniversidad Nacional Autónoma de México · MXYale University · US
Funding
Tumor Microenvironment and Metastasis ProgramP30CA082709 · NCI · INDIANA UNIV-PURDUE UNIV AT INDIANAPOLIS · PI Sara K Quinney · 1999 to 2026
$59.3MProject-005U54DK106846 · NIDDK · INDIANA UNIVERSITY INDIANAPOLIS · PI Reuben Kapur, Karen Elizabeth Pollok · 2015 to 2026
$9.7MImmunology and Infectious Diseases Training ProgramT32AI060519 · NIAID · INDIANA UNIV-PURDUE UNIV AT INDIANAPOLIS · PI MARK H KAPLAN · 2004 to 2026
$6.0MIndiana Medical Scientist/Engineer Training ProgramT32GM077229 · NIGMS · INDIANA UNIVERSITY INDIANAPOLIS · PI GASTON, BENJAMIN, HERBERT, BRITTNEY-SHEA · 2008 to 2022
$6.0MHost cellular network governing the development of post SARS-CoV-2 tissue sequelaeR01AI147394 · NIAID · UNIVERSITY OF VIRGINIA · PI Jie Sun · 2020 to 2026
$4.7MTSLP in Th2 Immunity and Allergic Airway InflammationR01AI085046 · NIAID · INDIANA UNIVERSITY INDIANAPOLIS · PI ZHOU, BAOHUA · 2010 to 2019
$3.8MElucidating the roles of alveolar macrophage inflammation and selfrenewal during influenza infectionR01AG069264 · NIA · UNIVERSITY OF VIRGINIA · PI Jie Sun · 2020 to 2026
$3.5MRole of p21 activated kinase in LeukemogenesisR01CA173852 · NCI · INDIANA UNIVERSITY INDIANAPOLIS · PI KAPUR, REUBEN · 2014 to 2025
$3.4MRole of Shp2 in FLT3-ITD-Induced LeukemogenesisR01CA134777 · NCI · INDIANA UNIVERSITY INDIANAPOLIS · PI KAPUR, REUBEN · 2011 to 2023
$3.4MTh9 cells in immediate hypersensitivityR01AI129241 · NIAID · INDIANA UNIVERSITY INDIANAPOLIS · PI KAPLAN, MARK H · 2017 to 2021
$2.0MBD FACSAria SystemS10OD012270 · OD · INDIANA UNIVERSITY INDIANAPOLIS · PI SROUR, EDWARD F · 2013 to 2013
$516kIL-9-secreting tissue-resident memory T cells in allergic airway diseaseF30HL147515 · NHLBI · INDIANA UNIVERSITY INDIANAPOLIS · PI ULRICH, BENJAMIN · 2019 to 2019
$30kNCI NIH HHS P30 CA082709NCI NIH HHS R01 CA134777NHLBI NIH HHS F30 HL147515NIAID NIH HHS R01 AI085046NIAID NIH HHS R01 AI129241NIAID NIH HHS R01 AI147394NIAID NIH HHS T32 AI060519NIA NIH HHS R01 AG069264NIDDK NIH HHS U54 DK106846NIGMS NIH HHS T32 GM077229NIH HHS S10 OD012270
Abstract
Despite IL-9 functioning as a pleiotropic cytokine in mucosal environments, the IL-9-responsive cell repertoire is still not well defined. Here, we found that IL-9 mediates proallergic activities in the lungs by targeting lung macrophages. IL-9 inhibits alveolar macrophage expansion and promotes recruitment of monocytes that develop into CD11c
Indexed as
AllergensAnimalsAntigens, DermatophagoidesArginaseAsthmaChemokine CCL5Child, PreschoolFemaleHumansInfantInflammationInterleukin-9Macrophages, AlveolarMaleMiceMice, Inbred C57BLAllergensAntigens, DermatophagoidesArginaseChemokine CCL5Interleukin-9Receptors, Interleukin-9
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