Evidence map›Paper›PMID 35179905›Full record

ArticleThe journal of physical chemistry. A2022

Interaction with a Biomolecule Facilitates the Formation of the Function-Determining Long-Lived Triplet State in a Ruthenium Complex for Photodynamic Therapy.

Avinash Chettri, Houston D Cole, John A Roque Iii, Kilian R A Schneider, Tingxiang Yang, Colin G Cameron, Sherri A McFarland, Benjamin Dietzek-Ivanšić

Abstract read
In one paragraph

Article in The journal of physical chemistry. A, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Avinash ChettriDepartment Functional Interfaces, Leibniz Institute of Photonic Technology Jena, Albert-Einstein-Straße 9, 07745 Jena, Germany.
Houston D ColeDepartment of Chemistry and Biochemistry, The University of Texas at Arlington, Arlington, Texas 76019, United States.
John A Roque IiiDepartment of Chemistry and Biochemistry, The University of Texas at Arlington, Arlington, Texas 76019, United States.
Kilian R A SchneiderDepartment Functional Interfaces, Leibniz Institute of Photonic Technology Jena, Albert-Einstein-Straße 9, 07745 Jena, Germany.
Tingxiang YangDepartment Functional Interfaces, Leibniz Institute of Photonic Technology Jena, Albert-Einstein-Straße 9, 07745 Jena, Germany.
Colin G CameronDepartment of Chemistry and Biochemistry, The University of Texas at Arlington, Arlington, Texas 76019, United States.ORCID https://orcid.org/0000-0003-0978-0894
Sherri A McFarlandDepartment of Chemistry and Biochemistry, The University of Texas at Arlington, Arlington, Texas 76019, United States.ORCID https://orcid.org/0000-0002-8028-5055
Benjamin Dietzek-IvanšićDepartment Functional Interfaces, Leibniz Institute of Photonic Technology Jena, Albert-Einstein-Straße 9, 07745 Jena, Germany.

Funding

Immunomodulating Ruthenium Metal Complexes for Melanoma PhotodynamicTherapyR01CA222227 · NCI · UNIVERSITY OF TEXAS ARLINGTON · PI GUJAR, SHASHI, MCFARLAND, SHERRI · 2018 to 2022
$2.6M
NCI NIH HHS R01 CA222227
6 · The paper itself

Abstract

TLD1433 is the first ruthenium (Ru)-based photodynamic therapy (PDT) agent to advance to clinical trials and is currently in a phase II study for treating nonmuscle bladder cancer with PDT. Herein, we present a photophysical study of TLD1433 and its derivative TLD1633 using complex, biologically relevant solvents to elucidate the excited-state properties that are key for biological activity. The complexes incorporate an imidazo [4,5-

Indexed as

PhotochemotherapyRutheniumLigandsPhenanthrolinesPhotosensitizing AgentsLigandsPhenanthrolinesPhotosensitizing AgentsRuthenium

Identifiers

PMID35179905
PMCPMC8903189

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.