Evidence map›Paper›PMID 35179826›Full record

ArticlePhysiological reports2022

Cardiomyocyte stromal interaction molecule 1 is a key regulator of Ca

Helen E Collins, Joshua C Anderson, Adam R Wende, John C Chatham

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Physiological reports, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.4field-weighted citation impact, top 48% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 3 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Helen E CollinsDivision of Environmental Medicine, Department of Medicine, University of Louisville, Louisville, Kentucky, USA.ORCID https://orcid.org/0000-0002-9302-6044
Joshua C AndersonDepartment of Radiation Oncology, University of Alabama at Birmingham, Birmingham, Alabama, USA.ORCID https://orcid.org/0000-0002-6977-9054
Adam R WendeDivision of Molecular and Cellular Pathology, Department of Pathology, University of Alabama at Birmingham, Birmingham, Alabama, USA.ORCID https://orcid.org/0000-0002-5536-4675
John C ChathamDivision of Molecular and Cellular Pathology, Department of Pathology, University of Alabama at Birmingham, Birmingham, Alabama, USA.ORCID https://orcid.org/0000-0001-7180-9948
University of Alabama at Birmingham · USUniversity of Louisville · US

Funding

STIM1 and its role in regulating cardiac metabolismR01HL149354 · NHLBI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI CHATHAM, JOHN C, DARLEY-USMAR, VICTOR M · 2020 to 2023
$2.2M
Glucose-Mediated Remodeling of Cardiac DNA MethylationR01HL133011 · NHLBI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI WENDE, ADAM RAYMOND · 2017 to 2020
$1.5M
The role of protein O-linked N-Acetylglucosamine in regulating cardiac physiologyR21HL152354 · NHLBI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI CHATHAM, JOHN C, WENDE, ADAM RAYMOND · 2020 to 2021
$408k
STIM1 mediated calcium entry: A new paradigm of metabolic regulation of cardiomyoR21HL110366 · NHLBI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI CHATHAM, JOHN C · 2012 to 2013
$407k
NHLBI NIH HHS R01 HL149354NHLBI NIH HHS R21 HL110366NHLBI NIH HHS R21 HL152354
6 · The paper itself

Abstract

Stromal interaction molecule 1 (STIM1) is a major regulator of store-operated calcium entry in non-excitable cells. Recent studies have suggested that STIM1 plays a role in pathological hypertrophy; however, the physiological role of STIM1 in the heart is not well understood. We have shown that mice with a cardiomyocyte deletion of STIM1 (

Indexed as

Action PotentialsAnimalsCalcineurinCalcium SignalingCells, CulturedCyclic GMP-Dependent Protein Kinase Type IEndoplasmic Reticulum StressHeart RateMaleMiceMice, Inbred C57BLMyocytes, CardiacProtein Kinase CStromal Interaction Molecule 1CalcineurinCyclic GMP-Dependent Protein Kinase Type IProtein Kinase CStim1 protein, mouseStromal Interaction Molecule 1calcium-dependentcardiomyocyteskinasesprotein kinase C (PKC)protein kinase G (PKG)store-operated calcium entry (SOCE)stromal interaction molecule 1 (STIM1)

Identifiers

PMID35179826
PMCPMC8855923
OpenAlexW4213139839

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.