ArticleAngewandte Chemie (International ed. in English)2022
Out-of-Equilibrium Self-Replication Allows Selection for Dynamic Kinetic Stability in a System of Competing Replicators.
Article in Angewandte Chemie (International ed. in English), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
21 citing papers in PubMed.
- Hierarchical Chiral Self-Assembly of Nanocylinders Composed of Sequence-Defined Mesogenic Dimers.Journal of the American Chemical Society · 2026Article
- Light-Driven Competitive Selection in a Protein-Catalyzed Dissipative Peptide Replication.Angewandte Chemie (International ed. in English) · 2026Article
- Native Chemical Ligation of Peptoid Oligomers.Biochemistry · 2026Article
- Spontaneous Mirror-Symmetry Breaking Destabilizes Racemates: A Route to Homochirality and Reversed Chemical Selectivity.Chemphyschem : a European journal of chemical physics and physical chemistry · 2025Article
- Light-mediated communication in responsive materials ranging from individual self-oscillators to feedback-driven network.Nature communications · 2025Article
- Chirality Effects in Peptide-Based Dynamic Combinatorial Chemistry.Chemistry (Weinheim an der Bergstrasse, Germany) · 2025Article
- Article
- Metabolism-inspired chemical reaction networks for chemically driven dissipative oligoesterification.Angewandte Chemie (International ed. in English) · 2025Article
- Bistable Functions and Signaling Motifs in Systems Chemistry: Taking the Next Step Toward Synthetic Cells.Accounts of chemical research · 2025Review
- Simultaneous Formation of a Foldamer and a Self-Replicator by Out-of-Equilibrium Dynamic Covalent Chemistry.Journal of the American Chemical Society · 2024Article
- Non-equilibrium self-assembly for living matter-like properties.Nature reviews. Chemistry · 2024Review
- Template-based copying in chemically fuelled dynamic combinatorial libraries.Nature chemistry · 2024Article
- Could Life Have Started on Mars? Planetary Conditions That Assemble and Destroy Protocells.Life (Basel, Switzerland) · 2024Article
- The protometabolic nature of prebiotic chemistry.Chemical Society reviews · 2023Review
- Assessment of Stoichiometric Autocatalysis across Element Groups.Journal of the American Chemical Society · 2023Article
- Enantioselective Self-Replicators.Journal of the American Chemical Society · 2023Article
- Light-Fueled Primitive Replication and Selection in Biomimetic Chemical Systems.Journal of the American Chemical Society · 2023Article
- On the Chemical Origin of Biological Cognition.Life (Basel, Switzerland) · 2022Article
- Construction of transient supramolecular polymers controlled by mass transfer in biphasic systems.Chemical science · 2022Article
- Collective adaptability in a replication network of minimal nucleobase sequences.Chemical science · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Among the key characteristics of living systems are their ability to self-replicate and the fact that they exist in an open system away from equilibrium. Herein, we show how the outcome of the competition between two self-replicators, differing in size and building block composition, is different depending on whether the experiments are conducted in a closed vial or in an open and out-of-equilibrium replication-destruction regime. In the closed system, the slower replicator eventually prevails over the faster competitor. In a replication-destruction regime, implemented through a flow system, the outcome of the competition is reversed and the faster replicator dominates. The interpretation of the experimental observations is supported by a mass-action-kinetics model. These results represent one of the few experimental manifestations of selection among competing self-replicators based on dynamic kinetic stability and pave the way towards Darwinian evolution of abiotic systems.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.