Evidence map›Paper›PMID 35179786›Full record

ArticleAlcoholism, clinical and experimental research2022

Dissociative symptomatology mediates the relation between posttraumatic stress disorder severity and alcohol-related problems.

Herry Patel, Charlene O'Connor, Krysta Andrews, Michael Amlung, Ruth Lanius, Margaret C McKinnon

Open access · hybridAbstract read
In one paragraph

Article in Alcoholism, clinical and experimental research, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
2.4field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 17 citations in OpenAlex.

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  4. The Roles of Dissociation and Depression in PTSD Among Soldiers Exposed to Combat.International journal of environmental research and public health · 2025
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  14. Women with PTSD and Substance Use Disorders in a Research Treatment Study: A Comparison of those with and without the Dissociative Subtype of PTSD.Journal of trauma & dissociation : the official journal of the International Society for the Study of Dissociation (ISSD)
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 4 institutions in 2 countries.

Herry PatelDepartment of Psychiatry and Behavioural Neurosciences, McMaster University, Hamilton, Ontario, Canada.ORCID 0000-0001-6899-103X
Charlene O'ConnorHomewood Health Care, Guelph, Ontario, Canada.
Krysta AndrewsDepartment of Psychiatry and Behavioural Neurosciences, McMaster University, Hamilton, Ontario, Canada.ORCID 0000-0001-6879-2292
Michael AmlungDepartment of Applied Behavioral Science, University of Kansas, Lawrence, Kansas, USA.ORCID 0000-0003-4483-7155
Ruth LaniusDepartment of Psychiatry, Western University, London, Ontario, Canada.ORCID 0000-0002-3758-1393
Margaret C McKinnonDepartment of Psychiatry and Behavioural Neurosciences, McMaster University, Hamilton, Ontario, Canada.ORCID 0000-0002-8315-7657
Homewood Research Institute · CAMcMaster University · CAUniversity of Kansas · USWestern University · CA

Funding

CIHR
6 · The paper itself

Abstract

backgroundUp to 50% of individuals with posttraumatic stress disorder (PTSD) endorse problematic alcohol use. Typically, these individuals present with more complex and often more severe PTSD symptoms than those who do not report problematic alcohol use. Emerging literature suggests that heightened symptoms of dissociation are likewise associated with greater PTSD symptom severity. Despite this knowledge, the role of dissociation in the relation between PTSD severity and alcohol-related problems has yet to be examined. Here, we explore the mediating role of dissociative symptomatology on the association between PTSD severity and alcohol-related problems within a PTSD treatment-seeking sample.

methodsStructural equation modeling was used to test the mediating role of dissociative symptomatology between PTSD severity and alcohol-related problems. Participants [N = 334; mean age (SD) = 44.29 (9.77), 50% female] were drawn from a clinical intake battery database for PTSD in-patient treatment services at Homewood Health Care, Guelph, ON, Canada. A subset of battery measures assessing PTSD severity, dissociative symptomatology, and alcohol-related problems were submitted to analysis.

resultsA significant positive association emerged between PTSD severity and alcohol-related problems (β = 0.127, p < 0.05) in the absence of dissociative symptomatology. Critically, however, when added to this model, dissociative symptomatology (six unique facets of dissociation assessed by the Multiscale Dissociation Inventory) mediated the relation between PTSD severity and alcohol-related problems. Specifically, greater PTSD severity was associated with greater dissociative symptomatology (β = 0.566, p < 0.0001), which was in turn associated with greater alcohol-related problems (β = 0.184, p < 0.05).

conclusionsThese results suggest that dissociative symptomatology plays a key role in explaining the relation between PTSD severity and alcohol-related problems. Future studies should examine the impact of targeting dissociative symptomatology specifically in treating individuals with PTSD who endorse alcohol-related problems.

Indexed as

AdultAlcohol-Related DisordersCross-Sectional StudiesDissociative DisordersEmotional RegulationFemaleHumansMaleMiddle AgedSeverity of Illness IndexStress Disorders, Post-Traumaticalcoholdissociationposttraumatic stress disordertreatment-seeking

Identifiers

PMID35179786
PMCPMC9307004
OpenAlexW4213108489

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.