ArticleeLife2022
Cannabidiol activates neuronal Kv7 channels.
Open access · goldAbstract read
In one paragraph
Article in eLife, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers, 2 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
36citing papers in PubMed, 2 pooled it
9.2field-weighted citation impact, top 1% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
36 citing papers in PubMed, 2 syntheses or guidelines pooled it, 54 citations in OpenAlex.
- Efficacy and safety of pharmacological and non-pharmacological therapies in Lennox-Gastaut syndrome: a systematic review and network meta-analysis.Frontiers in pharmacology · 2025Pooled it
- Persistent sodium currents in neurons: potential mechanisms and pharmacological blockers.Pflugers Archiv : European journal of physiology · 2024Pooled it
- (+)-Trans-Cannabidiol Is an Agonist at Human CBPharmacology research & perspectives · 2026Article
- Cannabidiol inhibits both human KActa pharmacologica Sinica · 2026Article
- Combinatorial logic of Nav channels in nociceptor excitability: Different degrees of synergy define distinct neuronal groups.bioRxiv : the preprint server for biology · 2026Article
- High-throughput multiplex voltage-clamp/current-clamp evaluation of acutely isolated neurons.Nature protocols · 2026Review
- Cannabinoid-based Pharmacology for the Management of Substance Use Disorders.Current topics in behavioral neurosciences · 2026Review
- Cannabidiol Reduces D1 and D2 Medium Spiny Neuron Excitability in the Nucleus Accumbens Core.bioRxiv : the preprint server for biology · 2025Article
- Cannabidiol dampens propagation of hippocampal hyperactivity and differentially modulates feedforward and feedback inhibition.bioRxiv : the preprint server for biology · 2025Article
- Cannabidiol Enhances Stress-Induced Cellular Damage: Potential Contribution of Kv2.1 Inhibition.Journal of molecular neuroscience : MN · 2025Article
- Mechanism-based nonopioid analgesic targets.The Journal of clinical investigation · 2025Review
- Beyond the hype: a comprehensive exploration of CBD's biological impacts and mechanisms of action.Journal of cannabis research · 2025Review
- Phosphatidylinositol 4,5-bisphosphate activation mechanism of human KCNQ5.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Nav1.8, an analgesic target for nonpsychotomimetic phytocannabinoids.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Utilization of Cannabidiol in Post-Organ-Transplant Care.International journal of molecular sciences · 2025Review
- Whole Plant Cannabinoid Nonpharmaceutical Treatment Protocols for a Young Male With Dravet Syndrome.Journal of chiropractic medicine · 2025Article
- Modulatory Effects of "Minor" Cannabinoids in an in vitro Model of Neuronal Hypersensitivity.Journal of pain research · 2025Article
- Cannabinoid inhibition of mechanosensitive KbioRxiv : the preprint server for biology · 2024Article
- Cannabidiol potentiates hyperpolarization-activated cyclic nucleotide-gated (HCN4) channels.The Journal of general physiology · 2024Article
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
13 authors at 2 institutions in 1 country.
Han-Xiong Bear Zhang *Department of Neurobiology, Harvard Medical School, Boston, United States.
Laurel Heckman *F.M. Kirby Neurobiology Research Center, Boston Children's Hospital, Boston, United States.ORCID 0000-0003-0124-0519
Zachary Niday *Department of Neurobiology, Harvard Medical School, Boston, United States.
Sooyeon Jo *Department of Neurobiology, Harvard Medical School, Boston, United States.
Akie FujitaDepartment of Neurobiology, Harvard Medical School, Boston, United States.
Jaehoon ShimF.M. Kirby Neurobiology Research Center, Boston Children's Hospital, Boston, United States.
Roshan PandeyF.M. Kirby Neurobiology Research Center, Boston Children's Hospital, Boston, United States.
Hoor Al JandalF.M. Kirby Neurobiology Research Center, Boston Children's Hospital, Boston, United States.
Selwyn JayakarF.M. Kirby Neurobiology Research Center, Boston Children's Hospital, Boston, United States.
Lee B BarrettF.M. Kirby Neurobiology Research Center, Boston Children's Hospital, Boston, United States.
Jennifer SmithICCB-Longwood Screening Facility and Department of Immunology, Harvard Medical School, Boston, United States.
Clifford J WoolfDepartment of Neurobiology, Harvard Medical School, Boston, United States.
Bruce P BeanDepartment of Neurobiology, Harvard Medical School, Boston, United States.ORCID 0000-0002-5093-3576
Boston Children's Hospital · USHarvard University · US
Funding
Unravelling Mechanisms and Novel Therapeutic Targets for Peripheral Neuropathy and Neuropathic Pain (Diversity Supplement)R35NS105076 · NINDS · BOSTON CHILDREN'S HOSPITAL · PI WOOLF, CLIFFORD J · 2018 to 2025
$9.5MGenetic Analysis and Manipulation Core (GAEC)P50HD105351 · NICHD · BOSTON CHILDREN'S HOSPITAL · PI SCOTT Loren POMEROY, MUSTAFA SAHIN · 2021 to 2026
$9.4MVOLTAGE DEPENDENT ION CHANNELS IN PURKINJE NEURONSR01NS036855 · NINDS · HARVARD UNIVERSITY (MEDICAL SCHOOL) · PI BEAN, BRUCE P · 1997 to 2022
$7.7MMouse Neurodevelopmental Behavior CoreU54HD090255 · NICHD · BOSTON CHILDREN'S HOSPITAL · PI SAHIN, MUSTAFA · 2016 to 2020
$5.2MVoltage-dependent ion channels in Purkinje neuronsR37NS036855 · NINDS · HARVARD UNIVERSITY (MEDICAL SCHOOL) · PI BEAN, BRUCE P · 2002 to 2008
$2.8MState-dependent interaction of antiepileptic drugs with voltage-dependent sodium channels and differential regulation of excitatory and inhibitory central neuronsR01NS110860 · NINDS · HARVARD MEDICAL SCHOOL · PI BEAN, BRUCE P · 2019 to 2022
$1.9MNICHD NIH HHS P50 HD105351NICHD NIH HHS U54 HD090255NINDS NIH HHS R01 NS036855NINDS NIH HHS R01 NS110860NINDS NIH HHS R35 NS105076NINDS NIH HHS R37 NS036855
Abstract
Cannabidiol (CBD), a chemical found in the
Indexed as
AnimalsCannabidiolCHO CellsCricetinaeCricetulusElectrophysiological PhenomenaGene Expression RegulationHumansKCNQ2 Potassium ChannelKCNQ3 Potassium ChannelNeuronsRatsCannabidiolKCNQ2 Potassium ChannelKCNQ3 Potassium ChannelcannabinoidsDravet syndromeepilepsyhippocampusKv7.2M-currentmouseneurosciencerat
Identifiers
What OpenQuestion holds
Textmetadata
LicenceCC BY
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.