Evidence map›Paper›PMID 35179306›Full record

ArticleInfluenza and other respiratory viruses2022

Incidence and seroprevalence of seasonal influenza a viruses in Egypt: Results of a community-based cohort study.

Mokhtar R Gomaa, Rebecca Badra, Amira S El Rifay, Ahmed Kandeil, Mina N Kamel, Noura M Abo Shama, Rabeh El-Shesheny, Ahmed B Barakat, Mohamed A Ali, Ghazi Kayali

Open access · goldAbstract read
In one paragraph

Article in Influenza and other respiratory viruses, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 1 pooled it
1.4field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 1 synthesis or guideline pooled it, 12 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 4 countries.

Mokhtar R GomaaCenter of Scientific Excellence for Influenza Virus, Environmental Research Division, National Research Centre, Giza, Egypt.
Rebecca BadraDepartment of Life Sciences, Human Link, Dubai, UAE.
Amira S El RifayCenter of Scientific Excellence for Influenza Virus, Environmental Research Division, National Research Centre, Giza, Egypt.
Ahmed KandeilCenter of Scientific Excellence for Influenza Virus, Environmental Research Division, National Research Centre, Giza, Egypt.
Mina N KamelCenter of Scientific Excellence for Influenza Virus, Environmental Research Division, National Research Centre, Giza, Egypt.
Noura M Abo ShamaCenter of Scientific Excellence for Influenza Virus, Environmental Research Division, National Research Centre, Giza, Egypt.
Rabeh El-SheshenyCenter of Scientific Excellence for Influenza Virus, Environmental Research Division, National Research Centre, Giza, Egypt.
Ahmed B BarakatDepartment of Microbiology, Faculty of Science, Ain Shams University, Cairo, Egypt.
Mohamed A AliCenter of Scientific Excellence for Influenza Virus, Environmental Research Division, National Research Centre, Giza, Egypt.
Ghazi KayaliDepartment of Life Sciences, Human Link, Dubai, UAE.ORCID 0000-0002-5387-1622
National Influenza Center · MNUniversity of Dubai · AEAin Shams University · EGSt. Jude Children's Research Hospital · US

Funding

NIAID Centers of Excellence for Influenza Research and Response: Universal Influenza Vaccine Research Activities75N93021C00016 · NIAID · ST. JUDE CHILDREN'S RESEARCH HOSPITAL · PI WEBBY, RICHARD · 2021 to 2025
$91.4M
NIAID NIH HHS 75N93021C00016NIAID NIH HHS HHSN272201400006C
6 · The paper itself

Abstract

backgroundH1N1 and H3N2 influenza A viruses circulate in people as seasonal influenza viruses. Data on influenza infection rates and circulation in demographic subpopulations in Egypt are limited. In this study, we aimed to determine the incidence and seroprevalence of seasonal influenza A virus infections in a cohort of rural Egyptians between 2017 and 2020.

methodsA total of 2383 subjects were enrolled from 390 households in five study sites in Northern Egypt. Informed consents were obtained. Sera were collected from participants on an annual basis (Baseline: 2016-2017, Follow up 1: 2017-2018, Follow up 2: 2018-2019, and Follow up 3: 2019-2020) to determine seroprevalence of antibodies against H1N1 and H3N2 viruses by hemagglutination inhibition assay and to estimate incidence based on seroconversion.

resultsSeropositivity against H1N1 was over 40% and over 60% against H3N2. The high seroprevalence was due to natural infection because participants were mostly unvaccinated. Seropositive participants were younger than seronegative participants indicating that the infection rate is higher in children. Incidence of both viruses ranged from 4% to 28% depending on study year. The incidence and seroprevalence of H3N2 and H1N1 infections at Follow up 1, 2, and 3 showed an increase at Follow up 2 observed for all age categories corresponding to season 2018-2019, at which the vaccine efficacy was the lowest worldwide compared with preceding and following seasons.

conclusionsThis cohort study provided estimates of influenza A infection rates among rural Egyptians. We recommend updating influenza vaccination programs to focus on such populations.

Indexed as

Influenza A virusInfluenza A Virus, H1N1 SubtypeInfluenza, HumanInfluenza VaccinesAntibodies, ViralChildCohort StudiesEgyptHumansIncidenceInfluenza A Virus, H3N2 SubtypeSeasonsSeroepidemiologic StudiesAntibodies, ViralInfluenza VaccinescohortEgyptincidenceseasonal influenzaseroprevalence

Identifiers

PMID35179306
PMCPMC9178055
OpenAlexW4213256772

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.