Evidence map›Paper›PMID 35179296›Full record

ArticleCytometry. Part B, Clinical cytometry2023

A series of case studies illustrating the role of flow cytometry in the diagnostic work-up of myelodysplastic syndromes.

Theresia M Westers, Leonie Saft, Vincent H J van der Velden, Jeroen G Te Marvelde, Alan Dunlop, Robin Ireland, Peter Valent, Anna Porwit, Marie C Béné, Arjan A van de Loosdrecht

Abstract read
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Article in Cytometry. Part B, Clinical cytometry, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Theresia M WestersDepartment of Hematology, Amsterdam University Medical Centers, VU University Medical Center, Cancer Center Amsterdam, Amsterdam, The Netherlands.ORCID 0000-0002-6504-3058
Leonie SaftDepartment of Pathology, Division of Hematopathology, Karolinska University Hospital and Institute, Stockholm, Sweden.
Vincent H J van der VeldenLaboratory Medical Immunology, Department of Immunology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands.ORCID 0000-0001-9457-3763
Jeroen G Te MarveldeLaboratory Medical Immunology, Department of Immunology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands.
Alan DunlopDepartment of Haemato-Oncology, Royal Marsden Hospital, London, UK.
Robin IrelandDepartment of Haematology and SE-HMDS, King's College Hospital NHS Foundation Trust, London, UK.
Peter ValentDepartment of Internal Medicine I, Division of Hematology and Hemostaseology, Medical University of Vienna, Vienna, Austria.
Anna PorwitDepartment of Clinical Sciences, Oncology and Pathology, Faculty of Medicine, Lund University, Lund, Sweden.ORCID 0000-0003-0709-2713
Marie C BénéHematology Biology, Nantes University Hospital and CRCINA, Nantes, France.ORCID 0000-0002-6569-7414
Arjan A van de LoosdrechtDepartment of Hematology, Amsterdam University Medical Centers, VU University Medical Center, Cancer Center Amsterdam, Amsterdam, The Netherlands.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Current guidelines recommend flow cytometric analysis as part of the diagnostic assessment of patients with cytopenia suspected for myelodysplastic syndrome. Herein we describe the complete work-up of six cases using multimodal integrated diagnostics. Flow cytometry assessments are illustrated by plots from conventional and more recent analysis tools. The cases demonstrate the added value of flow cytometry in case of hypocellular, poor quality, or ambiguous bone marrow cytomorphology. Moreover, they demonstrate how immunophenotyping results support clinical decision-making in inconclusive and clinically 'difficult' cases.

Indexed as

Myelodysplastic SyndromesBone MarrowBone Marrow CellsFlow CytometryHumansImmunophenotypingcytopeniadysplasiaflow cytometryintegrated diagnosticsMDS

Identifiers

PMID35179296
PMCPMC10078764

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.