ArticleChemistry (Weinheim an der Bergstrasse, Germany)2022
Efficient Synthesis for a Wide Variety of Patellamide Derivatives and Phosphatase Activity of Copper-Patellamide Complexes.
Article in Chemistry (Weinheim an der Bergstrasse, Germany), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed.
- Balgacyclamide A: Structural Revision of the First Reported Total Synthesis and Evaluation of Oxazoline Synthesis via β-Hydroxy Amides Dehydrative Cyclization Conditions.Chemistry (Weinheim an der Bergstrasse, Germany) · 2026Article
- Experimental Evidence for a Metal-Related Function of a Cyanobactin.Angewandte Chemie (International ed. in English) · 2026Article
- Catalytic Amide Activation with Thermally Stable Molybdenum(VI) Dioxide Complexes.The Journal of organic chemistry · 2023Article
- Efficient Synthesis for a Wide Variety of Patellamide Derivatives and Phosphatase Activity of Copper-Patellamide Complexes.Chemistry (Weinheim an der Bergstrasse, Germany) · 2022Article
- Possible Functional Roles of Patellamides in the Ascidian-Marine drugs · 2022Review
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Authors and funding
3 authors.
Funding
Abstract
Copper complexes of patellamides have shown catalytic activity in a variety of reactions but their biological function remains unknown. There are significant differences between the natural macrocycles and synthetic analogues in the various catalytic activities. It therefore is essential to be able to perform in vivo and ex vivo reference measurements with the natural patellamide macrocycles, very similar derivatives and a large range of synthetic analogues. The preparative method described allows for a highly adaptable synthetic process producing building blocks for a large range of patellamide derivatives: apart from natural compounds, a new synthetic patellamide was prepared that does not have any substituents at any of the four heterocycles. Together with the variation of substituents at the aliphatic backbone, this allowed to elucidate the catalytic activity for phosphoester hydrolysis as a function of the structure and dynamics of the dicopper(II)-patellamide complexes, both by experiment and DFT-based mechanistic studies.
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