Evidence map›Paper›PMID 35179228›Full record

Observational studyMuscle & nerve2022

Brief assessment of cognitive function in myotonic dystrophy: Multicenter longitudinal study using computer-assisted evaluation.

Gayle K Deutsch, Katharine A Hagerman, Jacinda Sampson, Gersham Dent, Jeanne Dekdebrun, Dana M Parker, Charles A Thornton, Chad R Heatwole, Sub H Subramony, Ami K Mankodi and 6 more

Open access · greenAbstract readMulticenter StudyObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in Muscle & nerve, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed, 1 pooled it
0.5field-weighted citation impact, top 45% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 1 synthesis or guideline pooled it, 5 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 8 institutions in 1 country.

Gayle K DeutschDepartment of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, CA.ORCID 0000-0001-6886-4356
Katharine A HagermanDepartment of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, CA.
Jacinda SampsonDepartment of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, CA.
Gersham DentBiogen, Cambridge, MA.
Jeanne DekdebrunDepartment of Neurology, The University of Rochester Medical Center, Rochester, NY.
Dana M ParkerDepartment of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, CA.
Charles A ThorntonDepartment of Neurology, The University of Rochester Medical Center, Rochester, NY.
Chad R HeatwoleDepartment of Neurology, The University of Rochester Medical Center, Rochester, NY.
Sub H SubramonyDepartment of Neurology, Norman Fixel Center for Neurological Disorders, University of Florida College of Medicine, Gainesville, FL.
Ami K MankodiNational Institute of Neurological Disorders and Stroke, Rockville, MD.
Tetsuo AshizawaDepartment of Neurology, Weill Cornell Medicine at Houston Methodist Hospital, Houston, TX.
Jeffrey M StatlandDepartment of Neurology, University of Kansas Medical Center, Kansas City, KS.ORCID 0000-0003-0790-5315
W David ArnoldDepartments of Neurology, PM&R, Neuroscience and Physiology and Cell Biology, The Ohio State University, Columbus, OH.
Richard T MoxleyDepartment of Neurology, The University of Rochester Medical Center, Rochester, NY.
John W DayDepartment of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, CA.
Myotonic Dystrophy Clinical Research Network
Stanford University · USUniversity of Rochester Medical Center · USBiogen (United States) · USCornell University · USNational Institute of Neurological Disorders and Stroke · USThe Ohio State University · USUniversity of Florida · USUniversity of Kansas Medical Center · US

Funding

Hereditary Muscle Disease UnitZIANS003131 · NINDS · NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE · PI MANKODI, AMI · 2012 to 2023
$11.7M
Senator Paul D. Wellstone Muscular Dystrophy Specialized Research CenterP50NS048843 · NINDS · UNIVERSITY OF ROCHESTER · PI THORNTON, CHARLES A · 2018 to 2022
$7.1M
BiogenMuscular Dystrophy Association MDA627906Myotonic Dystrophy FoundationNINDS NIH HHS P50 NS048843NINDS NIH HHS P50NS048843The Marigold Foundation
6 · The paper itself

Abstract

INTRODUCTION/

aimsMyotonic dystrophy type 1 (DM1) is known to affect cognitive function, but the best methods to assess central nervous system involvement in multicenter studies have not been determined. In this study our primary aim was to evaluate the potential of computerized cognitive tests to assess cognition in DM1.

methodsWe conducted a prospective, longitudinal, observational study of 113 adults with DM1 at six sites. Psychomotor speed, attention, working memory, and executive functioning were assessed at baseline, 3 months, and 12 months using computerized cognitive tests. Results were compared with assessments of muscle function and patient reported outcomes (PROs), including the Myotonic Dystrophy Health Index (MDHI) and the 5-dimension EuroQol (EQ-5D-5L) questionnaire.

resultsBased on intraclass correlation coefficients, computerized cognitive tests had moderate to good reliability for psychomotor speed (0.76), attention (0.82), working memory speed (0.79), working memory accuracy (0.65), and executive functioning (0.87). Performance at baseline was lowest for working memory accuracy (P < .0001). Executive function performance improved from baseline to 3 months (P < .0001), without further changes over 1 year. There was a moderate correlation between poorer executive function and larger CTG repeat size (r = -0.433). There were some weak associations between PROs and cognitive performance. DISCUSSION: Computerized tests of cognition are feasible in multicenter studies of DM1. Poor performance was exhibited in working memory, which may be a useful variable in clinical trials. Learning effects may have contributed to the improvement in executive functioning. The relationship between PROs and cognitive impairment in DM1 requires further study.

Indexed as

Myotonic DystrophyAdultCognitionComputersHumansLongitudinal StudiesProspective StudiesReproducibility of Resultsmuscle diseasemyotonic dystrophy type 1neuropsychologypatient-reported outcomequality of life

Identifiers

PMID35179228
PMCPMC9102286
OpenAlexW4212938955

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.